간세포암종 치료의 최신 지견
Advances in the treatment of hepatocellular carcinoma
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There have been recent advances in the treatment of hepatocellular carcinoma (HCC). There has been a clear change in the presentation of HCC, with an increased detection of tumors <2 cm in diameter as result of surveillance programs. In addition, the development of effective local treatment methods has led to the necessity for the selection of base therapeutic modalities on each patient’s characteristics. New promising image-guided therapies and new drugs, such as sorafenib, may address the enormous need for expanded treatment options for patients with HCC. Tailored therapies are needed to improve the treatment response and, ultimately, patient survival. Here, we review these advances in the management of HCC.
Abstract
There have been recent advances in the treatment of hepatocellular carcinoma (HCC). There has been a clear change in the presentation of HCC, with an increased detection of tumors <2 cm in diameter as result of surveillance programs. In addition, the development of effective local treatment methods has led to the necessity for the selection of base therapeutic modalities on each patient’s characteristics. New promising image-guided therapies and new drugs, such as sorafenib, may address the enormous need for expanded treatment options for patients with HCC. Tailored therapies are needed to improve the treatment response and, ultimately, patient survival. Here, we review these advances in the management of HCC.
참고문헌 (24)
- Livraghi T, "Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: is resection still the treatment of choice?", Hepatology, 47, pp.82~89 (2008)
- Llovet JM, "Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation", Hepatology, 30, pp.1434~1440 (1999)
- Zhou XD, "Experience of 1000 patients who underwent hepatectomy for small hepatocellular carcinoma", Cancer, 91, pp.1479~1486 (2001)
- Vauthey JN, "Simplified staging for hepatocellular carcinoma", J Clin Oncol, 20, pp.1527~1536 (2002)
- Poon RT, "Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: implications for a strategy of salvage transplantation", Ann Surg, 235, pp.373~382 (2002)
- Kumada T, "Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma", Hepatology, 25, pp.87~92 (1997)
- Imamura H, "Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy", J Hepatol, 38, pp.200~207 (2003)
- Llovet JM, "Resection and liver transplantation for hepatocellular carcinoma", Semin Liver Dis, 25, pp.181~200 (2005)
- Mazzaferro V, "Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis", N Engl J Med, 334, pp.693~699 (1996)
- Bismuth H, "Liver transplantation for hepatocellular carcinoma", Semin Liver, 19, pp.311~322 (1999)
- Roayaie S, "Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters", Ann Surg, 235, pp.533~539 (2002)
- Bruix J, "Management of hepatocellular carcinoma", Hepatology, 42, pp.1208~1236 (2005)
- Arii S, "Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan", Hepatology, 32, pp.1224~1229 (2000)
- Beaugrand M, "Local", regional and systemic treatments of hepatocellular carcinoma, 2005, pp.25, 201~211
- Livraghi T, "Small hepatocellular carcinoma: treatment with radio- frequency ablation versus ethanol injection", Radiology, 210, pp.655~661 (1999)
- Lencioni RA, "Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection", Radiology, 228, pp.235~240 (2003)
- Lin SM, "Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or =4 cm", Gastroenterology, 127, pp.1714~1723 (2004)
- Rhim H, "Major complications after radio-frequency thermal ablation of hepatic tumors: spectrum of imaging findings", Radiographics, 23, pp.123~134 (2003)
- de Baere T, "Adverse events during radiofrequency treatment of 582 hepatic tumors", AJR Am J Roentgenol, 181, pp.695~700 (2003)
- Chen MS, "A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma", Ann Surg, 243, pp.321~328
- Hong SN, "Comparing the outcomes of radiofrequency ablation and surgery in patients with a single small hepatocellular carcinoma and well-preserved hepatic function", J Clin Gastroenterol, 39, pp.247~252 (2005)
- Lupo L, "Single hepatocellular carcinoma ranging from 3 to 5 cm: radiofrequency ablation or resection?", HPB, 9, pp.429~434 (2007)
- Abu-Hilal M, "Surgical resection versus radiofrequency ablation in the treatment of small unifocal hepatocellular carcinoma", J Gastrointest Surg, 12, pp.1521~1526 (2008)
- Huang GT, "Percutaneous ethanol injection versus surgical resection for the treatment of small hepatocellular carcinoma: a prospective study", Ann Surg, 242, pp.36~42