Rituximab과 cyclophosphamide 투여로 호전된 저항성 청피반성 혈관염
Successful treatment of refractory livedoid vasculitis with rituximab and cyclophosphamide
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초록
저자들은 반복되는 피부 궤양에 대해 보존적인 치료와 함께 cyclosporine 및 mycophenolate mofetil로 면역억제치료를 하였으나 궤양이 호전되지 않는 저항성 청피반성 혈관염에서 rituximab과 cyclophosphamide 투여로 관해유도된 후 재발없이 유지되는 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Livedoid vasculitis (LV) is a chronic recurrent cutaneous disease that is characterized by a netlike vascular pattern of purpuric lesions that progress to ulcers and atrophic white scars. The etiology of LV is unknown. Various therapies have been used for LV with inconsistent results, including antiplatelet agents, fibrinolytics, anticoagulants, prostaglandin E1, and immunosuppressive agents, such as systemic corticosteroids, azathioprine, methotrexate, cyclosporine, and mycophenolate mofetil. We present a patient with idiopathic LV refractory to immunosuppressive therapy who had a good response to treatment with rituximab and cyclophosphamide.
참고문헌 (19)
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