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The Mechanism of and Preventive Therapy for Stroke in Patients with Atrial Fibrillation

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초록

Atrial fibrillation is a major cardiac cause of stroke, and a pathogenesis involving thrombus formation in patients with atrial fibrillation is well established. A strategy for rhythm control that involves catheter ablation and anticoagulation therapy is evolving. A strategy for rhythm control that restores and maintains sinus rhythm should reduce the risk of ischemic stroke that is associated with atrial fibrillation; however, this is yet to be proven in large-scale randomized controlled trials. This paper reviews the emerging role of rhythm control therapy for atrial fibrillation to prevent stroke.

Abstract

Atrial fibrillation is a major cardiac cause of stroke, and a pathogenesis involving thrombus formation in patients with atrial fibrillation is well established. A strategy for rhythm control that involves catheter ablation and anticoagulation therapy is evolving. A strategy for rhythm control that restores and maintains sinus rhythm should reduce the risk of ischemic stroke that is associated with atrial fibrillation; however, this is yet to be proven in large-scale randomized controlled trials. This paper reviews the emerging role of rhythm control therapy for atrial fibrillation to prevent stroke.

참고문헌 (82)

  1. Chugh SS, "Worldwide epidemiology of atrial fibrillation : a Global Burden of Disease 2010 Study", Circulation, 129, pp.837~847 (2014)
  2. Phillips SJ, "Is atrial fibrillation an independent risk factor for stroke?", Can J Neurol Sci, 17, pp.163~168 (1990)
  3. Go AS, "Prevalence of diagnosed atrial fibrillation in adults : national implications for rhythm management and stroke prevention : the AnTicoagulation and Risk Factors in Atrial Fibrillation(ATRIA)Study", JAMA, 285, pp.2370~2375 (2001)
  4. Marini C, "Contribution of atrial fibrillation to incidence and outcome of ischemic stroke : results from a population-based study", Stroke, 36, pp.1115~1119 (2005)
  5. Sacco RL, "Infarcts of undetermined cause : the NINCDS Stroke Data Bank", Ann Neurol, 25, pp.382~390 (1989)
  6. Jauch EC, "Guidelines for the early management of patients with acute ischemic stroke : a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2013, pp.44, 870~947
  7. Kernan WN, "Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack : a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2014, pp.45, 2160~2236
  8. Dussault C, "Electrocardiographic monitoring for detecting atrial fibrillation after ischemic stroke or transient ischemic attack : systematic review and meta-analysis", Circ Arrhythm Electrophysiol, 8, pp.263~269 (2015)
  9. Poller L, "Dabigatran versus warfarin in patients with atrial fibrillation", N Engl J Med, 361, pp.2673~2674 (2009)
  10. Patel MR, "Rivaroxaban versus warfarin in nonvalvular atrial fibrillation", N Engl J Med, 365, pp.883~891 (2011)
  11. Granger CB, "Apixaban versus warfarin in patients with atrial fibrillation", N Engl J Med, 365, pp.981~992 (2011)
  12. Ostermayer SH, "Percutaneous left atrial appendage transcatheter occlusion(PLAATO system)to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation : results from the international multi-center feasibility trials", J Am Coll Cardiol, 46, pp.9~14 (2005)
  13. Holmes DR, "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation : a randomised non-inferiority trial", Lancet, 374, pp.534~542 (2009)
  14. Hagens VE, "Rate control versus rhythm control for patients with persistent atrial fibrillation with mild to moderate heart failure : results from the RAte Control versus Electrical cardioversion(RACE)study", Am Heart J, 149, pp.1106~1111 (2005)
  15. Corley SD, "Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study", Circulation, 109, pp.1509~1513 (2004)
  16. Andrade J, "The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms", Circ Res, 114, pp.1453~1468 (2014)
  17. Putaala J, "Prime time for dissecting the entity of cryptogenic stroke", Stroke, 45, pp.950~952 (2014)
  18. Gladstone DJ, "Atrial fibrillation in patients with cryptogenic stroke", N Engl J Med, 370, pp.2467~2477 (2014)
  19. Brambatti M, "Temporal relationship between subclinical atrial fibrillation and embolic events", Circulation, 129, pp.2094~2099 (2014)
  20. Martin DT, "Randomized trial of atrial arrhythmia monitoring to guide anticoagulation in patients with implanted defibrillator and cardiac resynchronization devices", Eur Heart J, 36, pp.1660~1668 (2015)
  21. Ip J, "Multicenter randomized study of anticoagulation guided by remote rhythm monitoring in patients with implantable cardioverter-defibrillator and CRT-D devices: rationale, design, and clinical characteristics of the initially enrolled cohort The IMPACT study", Am Heart J, 158, pp.364~370 (2009)
  22. Daccarett M, "Association of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation", J Am Coll Cardiol, 57, pp.831~838 (2011)
  23. Akoum N, "Association of atrial fibrosis quantified using LGE-MRI with atrial appendage thrombus and spontaneous contrast on transesophageal echocardiography in patients with atrial fibrillation", J Cardiovasc Electrophysiol, 24, pp.1104~1109 (2013)
  24. Pollick C, "Assessment of left atrial appendage function by transesophageal echocardiography. Implications for the development of thrombus", Circulation, 84, pp.223~231 (1991)
  25. Leung DY, "Prognostic implications of left atrial spontaneous echo contrast in nonvalvular atrial fibrillation", J Am Coll Cardiol, 24, pp.755~762 (1994)
  26. study), "J Am Soc Echocardiogr", 1999, 1088~1096
  27. Habibi M, "Association of left atrial function and left atrial enhancement in patients with atrial fibrillation: cardiac magnetic resonance study", Circ Cardiovasc Imaging, 8, pp.e002769~ (2015)
  28. Mahnkopf C, "Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI : implications for disease progression and response to catheter ablation", Heart Rhythm, 7, pp.1475~1481 (2010)
  29. Akoum N, "Atrial fibrosis helps select the appropriate patient and strategy in catheter ablation of atrial fibrillation : a DE-MRI guided approach", J Cardiovasc Electrophysiol, 22, pp.16~22 (2011)
  30. Beinart R, "Cardiac magnetic resonance T1 mapping of left atrial myocardium", Heart Rhythm, 10, pp.1325~1331 (2013)
  31. Fluckiger JU, "Left atrial flow velocity distribution and flow coherence using four-dimensional FLOW MRI : a pilot study investigating the impact of age and Pre-and Postintervention atrial fibrillation on atrial hemodynamics", J Magn Reson Imaging, 38, pp.580~587 (2013)
  32. Yamamoto M, "Complex left atrial appendage morphology and left atrial appendage thrombus formation in patients with atrial fibrillation", Circ Cardiovasc Imaging, 7, pp.337~343 (2014)
  33. Fatkin D, "Relations between left atrial appendage blood flow velocity, spontaneous echocardiographic contrast and thromboembolic risk in vivo", J Am Coll Cardiol, 23, pp.961~969 (1994)
  34. Beinart R, "Left atrial appendage dimensions predict the risk of stroke", TIA in patients with atrial fibrillation, 2011, pp.22, 10~15
  35. Mügge A, "Assessment of left atrial appendage function by biplane transesophageal echocardiography in patients with nonrheumatic atrial fibrillation : identification of a subgroup of patients at increased embolic risk", J Am Coll Cardiol, 23, pp.599~607 (1994)
  36. Kishima H, "Masuyama T. Does Left Atrial Appendage Morphology Influence Left Atrial Appendage Flow Velocity?", Circ J, 79, pp.1706~1711 (2015)
  37. Fukushima K, "Correlation between left atrial appendage morphology and flow velocity in patients with paroxysmal atrial fibrillation", Eur Heart J Cardiovasc Imaging, 17, pp.59~66 (2016)
  38. Di Biase L, "Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study", J Am Coll Cardiol, 60, pp.531~538 (2012)
  39. Nedios S, "Left atrial appendage morphology and thromboembolic risk after catheter ablation for atrial fibrillation", Heart Rhythm, 11, pp.2239~2246 (2014)
  40. Shin SY, "Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation", J Cardiovasc Electrophysiol, 22, pp.376~382 (2011)
  41. Tousoulis D, "Oxidative stress and inflammatory process in patients with atrial fibrillation : the role of left atrium distension", Int J Cardiol, 136, pp.258~262 (2009)
  42. Makin AJ, "Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor", Eur Heart J, 25, pp.371~376 (2004)
  43. Chung MK, "C-reactive protein elevation in patients with atrial arrhythmias : inflammatory mechanisms and persistence of atrial fibrillation", Circulation, 104, pp.2886~2891 (2001)
  44. Study), "Am J Cardiol", 2012, 95~99
  45. Lip GY, "Increased markers of thrombogenesis in chronic atrial fibrillation : effects of warfarin treatment", Br Heart J, 73, pp.527~533 (1995)
  46. Heppell RM, "Haemostatic and haemodynamic abnormalities associated with left atrial thrombosis in non-rheumatic atrial fibrillation", Heart, 77, pp.407~411 (1997)
  47. Lip GY, "Additive role of plasma von Willebrand factor levels to clinical factors for risk stratification of patients with atrial fibrillation", Stroke, 37, pp.2294~2300 (2006)
  48. Cooke JP, "Asymmetrical dimethylarginine: the Uber marker?", Circulation, 109, pp.1813~1818 (2004)
  49. Matsuoka H, "Asymmetrical dimethylarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension", Hypertension, 29, pp.242~247 (1997)
  50. Abbasi F, "Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus", Am J Cardiol, 88, pp.1201~1203 (2001)
  51. Miyazaki H, "Endogenous nitric oxide synthase inhibitor : a novel marker of atherosclerosis", Circulation, 99, pp.1141~1146 (1999)
  52. Skanes AC, "Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines : recommendations for stroke prevention and rate", rhythm control, 2012, pp.28, 125~136
  53. Cowan C, "The use of anticoagulants in the management of atrial fibrillation among general practices in England", Heart, 99, pp.1166~1172 (2013)
  54. O’Brien EC, "Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation : findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation(ORBIT-AF)registry", Am Heart J, 167, pp.601~609 (2014)
  55. Sacco RL, "An updated definition of stroke for the 21st century : a statement for healthcare professionals from the American Heart Association", American Stroke Association, 2013, pp.44, 2064~2089
  56. Brott T, "Baseline silent cerebral infarction in the Asymptomatic Carotid Atherosclerosis Study", Stroke, 25, pp.1122~1129 (1994)
  57. Hara M, "Silent cortical strokes associated with atrial fibrillation", Clin Cardiol, 18, pp.573~574 (1995)
  58. Cha MJ, "Prevalence of and risk factors for silent ischemic stroke in patients with atrial fibrillation as determined by brain magnetic resonance imaging", Am J Cardiol, 113, pp.655~661 (2014)
  59. Marfella R, "Brief episodes of silent atrial fibrillation predict clinical vascular brain disease in type 2 diabetic patients", J Am Coll Cardiol, 62, pp.525~530 (2013)
  60. Kalantarian S, "Cognitive impairment associated with atrial fibrillation : a meta-analysis", Ann Intern Med, 158, pp.338~346 (2013)
  61. Gaita F, "Prevalence of silent cerebral ischemia in paroxysmal and persistent atrial fibrillation and correlation with cognitive function", J Am Coll Cardiol, 62, pp.1990~1997 (2013)
  62. Roy D, "Amiodarone to prevent recurrence of atrial fibrillation. Canadian Trial of Atrial Fibrillation Investigators", N Engl J Med, 342, pp.913~920 (2000)
  63. Bonanno C, "Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation : a meta-analysis of randomized trials", J Cardiovasc Med, 11, pp.408~418 (2010)
  64. Jais P, "Catheter ablation versus antiarrhythmic drugs for atrial fibrillation : the A4 study", Circulation, 118, pp.2498~2505 (2008)
  65. Pappone C, "A randomized trial of circumferential pulmonary vein ablation versus antiarrhythmic drug therapy in paroxysmal atrial fibrillation : the APAF Study", J Am Coll Cardiol, 48, pp.2340~2347 (2006)
  66. Piccini JP, "Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials", Circ Arrhythm Electrophysiol, 2, pp.626~633 (2009)
  67. Bunch TJ, "Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation", J Cardiovasc Electrophysiol, 22, pp.839~845 (2011)
  68. Reynolds MR, "Health outcomes with catheter ablation or antiarrhythmic drug therapy in atrial fibrillation : results of a propensity-matched analysis", Circ Cardiovasc Qual Outcomes, 5, pp.171~181 (2012)
  69. Chang CH, "Effect of radiofrequency catheter ablation for atrial fibrillation on morbidity and mortality : a nationwide cohort study and propensity score analysis", Circ Arrhythm Electrophysiol, 7, pp.76~82 (2014)
  70. Haissaguerre M, "Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins", N Engl J Med, 339, pp.659~666 (1998)
  71. Oral H, "Risk of thromboembolic events after percutaneous left atrial radiofrequency ablation of atrial fibrillation", Circulation, 114, pp.759~765 (2006)
  72. Nademanee K, "Clinical outcomes of catheter substrate ablation for high-risk patients with atrial fibrillation", J Am Coll Cardiol, 51, pp.843~849 (2008)
  73. Bunch TJ, "Warfarin is not needed in low-risk patients following atrial fibrillation ablation procedures", J Cardiovasc Electrophysiol, 20, pp.988~993 (2009)
  74. Themistoclakis S, "The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation", J Am Coll Cardiol, 55, pp.735~743 (2010)
  75. Saad EB, "Very low risk of thromboembolic events in patients undergoing successful catheter ablation of atrial fibrillation with a CHADS2 score ≤3 : a long-term outcome study", Circ Arrhythm Electrophysiol, 4, pp.615~621 (2011)
  76. Yagishita A, "Incidence of late thromboembolic events after catheter ablation of atrial fibrillation", Circ J, 75, pp.2343~2349 (2011)
  77. Guiot A, "Anticoagulant therapy and risk of cerebrovascular events after catheter ablation of atrial fibrillation in the elderly", J Cardiovasc Electrophysiol, 23, pp.36~43 (2012)
  78. Friberg L, "Catheter ablation for atrial fibrillation is associated with lower incidence of stroke and death: data from Swedish health registries", Eur Heart J (2016)[DOI]
  79. Bertaglia E, "Long term follow up of radiofrequency catheter ablation of atrial flutter : clinical course and predictors of atrial fibrillation occurrence", Heart, 90, pp.59~63 (2004)
  80. Medi C, "Pulmonary vein antral isolation for paroxysmal atrial fibrillation : results from long-term follow-up", J Cardiovasc Electrophysiol, 22, pp.137~141 (2011)
  81. Ouyang F, "Long-term results of catheter ablation in paroxysmal atrial fibrillation : lessons from a 5-year follow-up", Circulation, 122, pp.2368~2377 (2010)
  82. Wokhlu A, "Long-term outcome of atrial fibrillation ablation : impact and predictors of very late recurrence", J Cardiovasc Electrophysiol, 21, pp.1071~1078 (2010)

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