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Spontaneous Intracerebral Hemorrhage: Management

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초록

Spontaneous non-traumatic intracerebral hemorrhage (ICH) remains a significant cause of mortality and morbidity throughout the world. To improve the devastating course of ICH, various clinical trials for medical and surgical interventions have been conducted in the last 10 years. Recent large-scale clinical trials have reported that early intensive blood pressure reduction can be a safe and feasible strategy for ICH, and have suggested a safe target range for systolic blood pressure. While new medical therapies associated with warfarin and non-vitamin K antagonist oral anticoagulants have been developed to treat ICH, recent trials have not been able to demonstrate the overall beneficial effects of surgical intervention on mortality and functional outcomes. However, some patients with ICH may benefit from surgical management in specific clinical contexts and/or at specific times. Furthermore, clinical trials for minimally invasive surgical evacuation methods are ongoing and may provide positive evidence. Upon understanding the current guidelines for the management of ICH, clinicians can administer appropriate treatment and attempt to improve the clinical outcome of ICH. The purpose of this review is to help in the decision-making of the medical and surgical management of ICH.

Abstract

Spontaneous non-traumatic intracerebral hemorrhage (ICH) remains a significant cause of mortality and morbidity throughout the world. To improve the devastating course of ICH, various clinical trials for medical and surgical interventions have been conducted in the last 10 years. Recent large-scale clinical trials have reported that early intensive blood pressure reduction can be a safe and feasible strategy for ICH, and have suggested a safe target range for systolic blood pressure. While new medical therapies associated with warfarin and non-vitamin K antagonist oral anticoagulants have been developed to treat ICH, recent trials have not been able to demonstrate the overall beneficial effects of surgical intervention on mortality and functional outcomes. However, some patients with ICH may benefit from surgical management in specific clinical contexts and/or at specific times. Furthermore, clinical trials for minimally invasive surgical evacuation methods are ongoing and may provide positive evidence. Upon understanding the current guidelines for the management of ICH, clinicians can administer appropriate treatment and attempt to improve the clinical outcome of ICH. The purpose of this review is to help in the decision-making of the medical and surgical management of ICH.

참고문헌 (108)

  1. Feigin VL, "Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review", Lancet Neurol, 8, pp.355~369 (2009)
  2. Steiner T, "European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage", Int J Stroke, 9, pp.840~855 (2014)
  3. van Asch CJ, "Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis", Lancet Neurol, 9, pp.167~176 (2010)
  4. Hemphill JC 3rd, "Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2015, pp.46, 2032~2060
  5. Hemphill JC 3rd, "The ICH score: a simple, reliable grading scale for intracerebral hemorrhage", Stroke, 32, pp.891~897 (2001)
  6. Mayer SA, "Treatment of intracerebral haemorrhage", Lancet Neurol, 4, pp.662~672 (2005)
  7. Moon JS, "Prehospital neurologic deterioration in patients with intracerebral hemorrhage", Crit Care Med, 36, pp.172~175 (2008)
  8. Fan JS, "Emergency department neurologic deterioration in patients with spontaneous intracerebral hemorrhage: incidence, predictors, and prognostic significance", Acad Emerg Med, 19, pp.133~138 (2012)
  9. Chalela JA, "Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison", Lancet, 369, pp.293~298 (2007)
  10. Fiebach JB, "Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging", Stroke, 35, pp.502~506 (2004)
  11. Jauch EC, "Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2013, pp.44, 870~947
  12. Andrews CM, "Emergency neurological life support: intracerebral hemorrhage", Neurocrit Care, 17(Suppl 1), pp.S37~S46 (2012)
  13. Bernstein RA, "Critical care of acute ischemic stroke", Curr Neurol Neurosci Rep, 1, pp.587~592 (2001)
  14. Bruce SS, "A comparative evaluation of existing grading scales in intracerebral hemorrhage", Neurocrit Care, 15, pp.498~505 (2011)
  15. Hemphill JC 3rd, "Prospective validation of the ICH Score for 12-month functional outcome", Neurology, 73, pp.1088~1094 (2009)
  16. Ji R, "A novel risk score to predict 1-year functional outcome after intracerebral hemorrhage and comparison with existing scores", Crit Care, 17, pp.R275~ (2013)
  17. Rost NS, "Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score", Stroke, 39, pp.2304~2309 (2008)
  18. Sun W, "Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage", Neurocrit Care, 19, pp.299~305 (2013)
  19. Leira R, "Early neurologic deterioration in intracerebral hemorrhage: predictors and associated factors", Neurology, 63, pp.461~467 (2004)
  20. Sorimachi T, "Early neurological change in patients with spontaneous supratentorial intracerebral hemorrhage", J Clin Neurosci, 17, pp.1367~1371 (2010)
  21. Diringer MN, "Admission to a neurologic", neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage, 2001, pp.29, 635~640
  22. Terent A, "Stroke unit care revisited: who benefits the most? A cohort study of 105,043 patients in Riks-Stroke, the Swedish Stroke Register", J Neurol Neurosurg Psychiatry, 80, pp.881~887 (2009)
  23. Rodriguez-Luna D, "Impact of blood pressure changes and course on hematoma growth in acute intracerebral hemorrhage", Eur J Neurol, 20, pp.1277~1283 (2013)
  24. Sakamoto Y, "Systolic blood pressure after intravenous antihypertensive treatment and clinical outcomes in hyperacute intracerebral hemorrhage: the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study", Stroke, 44, pp.1846~1851 (2013)
  25. Zhang Y, "Blood pressure and clinical outcome among patients with acute stroke in Inner Mongolia, China", J Hypertens, 26, pp.1446~1452 (2008)
  26. Naval NS, "Management of spontaneous intracerebral hemorrhage", Neurol Clin, 26, pp.373~384 (2008)
  27. Butcher KS, "The intracerebral hemorrhage acutely decreasing arterial pressure trial", Stroke, 44, pp.620~626 (2013)
  28. Anderson CS, "Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage", N Engl J Med, 368, pp.2355~2365 (2013)
  29. Anderson CS, "Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial", Lancet Neurol, 7, pp.391~399 (2008)
  30. Qureshi AI, "Effect of systolic blood pressure reduction on hematoma expansion, perihematomal edema, and 3-month outcome among patients with intracerebral hemorrhage: results from the antihypertensive treatment of acute cerebral hemorrhage study", Arch Neurol, 67, pp.570~576 (2010)
  31. Adeoye O, "Advances in the management of intracerebral hemorrhage", Nat Rev Neurol, 6, pp.593~601 (2010)
  32. Qureshi AI, "Intensive blood-pressure lowering in patients with acute cerebral hemorrhage", N Engl J Med, 375, pp.1033~1043 (2016)
  33. Eikelboom JW, "Idarucizumab: the antidote for reversal of dabigatran", Circulation, 132, pp.2412~2422 (2015)
  34. Pollack CV Jr, "Idarucizumab for dabigatran reversal", N Engl J Med, 373, pp.511~520 (2015)
  35. Schreuder FH, "Medical management of intracerebral haemorrhage", J Neurol Neurosurg Psychiatry, 88, pp.76~84 (2017)
  36. Connolly SJ, "Andexanet alfa for acute major bleeding associated with factor Xa inhibitors", N Engl J Med, 375, pp.1131~1141 (2016)
  37. Siegal DM, "Andexanet alfa for the reversal of factor Xa inhibitor activity", N Engl J Med, 373, pp.2413~2424 (2015)
  38. Konkle BA, "Monitoring target specific anticoagulants", J Thromb Thrombolysis, 35, pp.387~390 (2013)
  39. Tran H, "New oral anticoagulants: a practical guide on prescription, laboratory testing and peri-procedural", bleeding management. Australasian Society of Thrombosis and Haemostasis, 2014, pp.44, 525~536
  40. Douxfils J, "Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate", Thromb Haemost, 107, pp.985~997 (2012)
  41. Harenberg J, "Determination of dabigatran in human plasma samples", Semin Thromb Hemost, 38, pp.16~22 (2012)
  42. Lindahl TL, "Effects of the oral, direct thrombin inhibitor dabigatran on five common coagulation assays", Thromb Haemost, 105, pp.371~378 (2011)
  43. Harenberg J, "Determination of rivaroxaban in human plasma samples", Semin Thromb Hemost, 38, pp.178~184 (2012)
  44. Douxfils J, "Impact of apixaban on routine and specific coagulation assays: a practical laboratory guide", Thromb Haemost, 110, pp.283~294 (2013)
  45. Kuramatsu JB, "Anticoagulant reversal, blood pressure levels, and anticoagulant resumption in patients with anticoagulation-related intracerebral hemorrhage", JAMA, 313, pp.824~836 (2015)
  46. Poli D, "Recurrence of ICH after resumption of anticoagulation with VK antagonists: CHIRONE study", Neurology, 82, pp.1020~1026 (2014)
  47. Majeed A, "Optimal timing of resumption of warfarin after intracranial hemorrhage", Stroke, 41, pp.2860~2866 (2010)
  48. Eckman MH, "Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis", Stroke, 34, pp.1710~1716 (2003)
  49. Schulman S, "Resumption of oral anticoagulation after warfarin-associated intracerebral hemorrhage: no", Stroke, 42, pp.3663~3664 (2011)
  50. Biffi A, "Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy", Neurology, 75, pp.693~698 (2010)
  51. Flynn RW, "Prescribing antiplatelet medicine and subsequent events after intracerebral hemorrhage", Stroke, 41, pp.2606~2611 (2010)
  52. Investigators A, "Effect of clopidogrel added to aspirin in patients with atrial fibrillation", N Engl J Med, 360, pp.2066~2078 (2009)
  53. Connolly SJ, "Dabigatran versus warfarin in patients with atrial fibrillation", N Engl J Med, 361, pp.1139~1151 (2009)
  54. Granger CB, "Apixaban versus warfarin in patients with atrial fibrillation", N Engl J Med, 365, pp.981~992 (2011)
  55. Patel MR, "Rivaroxaban versus warfarin in nonvalvular atrial fibrillation", N Engl J Med, 365, pp.883~891 (2011)
  56. Naidech AM, "Platelet activity and outcome after intracerebral hemorrhage", Ann Neurol, 65, pp.352~356 (2009)
  57. Naidech AM, "Reduced platelet activity is associated with early clot growth and worse 3-month outcome after intracerebral hemorrhage", Stroke, 40, pp.2398~2401 (2009)
  58. Sansing LH, "Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH", Neurology, 72, pp.1397~1402 (2009)
  59. de Gans K, "PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial", BMC Neurol, 10, pp.19~ (2010)
  60. Chan S, "Critical care management of intracerebral hemorrhage", Crit Care Clin, 30, pp.699~717 (2014)
  61. Collaboration CT, "Thigh-length versus below-knee stockings for deep venous thrombosis prophylaxis after stroke: a randomized trial", Ann Intern Med, 153, pp.553~562 (2010)
  62. Collaboration CT, "Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial", Lancet, 382, pp.516~524 (2013)
  63. Collaboration CT, "The effect of graduated compression stockings on long-term outcomes after stroke: the CLOTS trials 1 and 2", Stroke, 44, pp.1075~1079 (2013)
  64. Collaboration CT, "Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial", Lancet, 373, pp.1958~1965 (2009)
  65. Paciaroni M, "Efficacy and safety of anticoagulants in the prevention of venous thromboembolism in patients with acute cerebral hemorrhage: a meta-analysis of controlled studies", J Thromb Haemost, 9, pp.893~898 (2011)
  66. Guyatt GH, "Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines", Chest, 141, pp.7S~47S (2012)
  67. Kamel H, "Characteristics and sequelae of intracranial hypertension after intracerebral hemorrhage", Neurocrit Care, 17, pp.172~176 (2012)
  68. Kamel H, "Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trials", Crit Care Med, 39, pp.554~559 (2011)
  69. Poungvarin N, "Effects of dexamethasone in primary supratentorial intracerebral hemorrhage", N Engl J Med, 316, pp.1229~1233 (1987)
  70. Schwarz S, "Incidence and prognostic significance of fever following intracerebral hemorrhage", Neurology, 54, pp.354~361 (2000)
  71. Kollmar R, "Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage", Stroke, 41, pp.1684~1689 (2010)
  72. Fingas M, "Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia", Exp Neurol, 219, pp.156~162 (2009)
  73. Fogelholm R, "Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study", J Neurol Neurosurg Psychiatry, 76, pp.349~353 (2005)
  74. Investigators N-SS, "Intensive versus conventional glucose control in critically ill patients", N Engl J Med, 360, pp.1283~1297 (2009)
  75. Vespa P, "Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate", pyruvate ratio after traumatic brain injury, 2006, pp.34, 850~856
  76. Bladin CF, "Seizures after stroke: a prospective multicenter study", Arch Neurol, 57, pp.1617~1622 (2000)
  77. Claassen J, "Electrographic seizures and periodic discharges after intracerebral hemorrhage", Neurology, 69, pp.1356~1365 (2007)
  78. Szaflarski JP, "Incidence of seizures in the acute phase of stroke: a population-based study", Epilepsia, 49, pp.974~981 (2008)
  79. Beghi E, "Incidence and predictors of acute symptomatic seizures after stroke", Neurology, 77, pp.1785~1793 (2011)
  80. De Herdt V, "Early seizures in intracerebral hemorrhage: incidence, associated factors, and outcome", Neurology, 77, pp.1794~1800 (2011)
  81. Lyden PD, "Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial", Stroke, 38, pp.2262~2269 (2007)
  82. Maramattom BV, "Pulmonary complications after intracerebral hemorrhage", Neurocrit Care, 5, pp.115~119 (2006)
  83. Hinchey JA, "Formal dysphagia screening protocols prevent pneumonia", Stroke, 36, pp.1972~1976 (2005)
  84. Holloway RG, "Palliative and end-of-life care in stroke: a statement for healthcare professionals from the American Heart Association", American Stroke Association, 2014, pp.45, 1887~1916
  85. Da Pian R, "Surgical versus medical treatment of spontaneous posterior fossa haematomas: a cooperative study on 205 cases", Neurol Res, 6, pp.145~151 (1984)
  86. Firsching R, "Cerebellar haemorrhage: management and prognosis", Neurosurg Rev, 14, pp.191~194 (1991)
  87. Komiyama M, "A clinical analysis of 32 brainstem haemorrhages; with special reference to surviving but severely disabled cases", Acta Neurochir (Wien), 101, pp.46~51 (1989)
  88. Manno EM, "Emerging medical and surgical management strategies in the evaluation and treatment of intracerebral hemorrhage", Mayo Clin Proc, 80, pp.420~433 (2005)
  89. Hara T, "Functional outcome of primary pontine hemorrhage: conservative treatment or stereotaxic surgery", No Shinkei Geka, 29, pp.823~829 (2001)
  90. Mangiardi JR, "Brainstem haematomas: review of the literature and presentation of five new cases", J Neurol Neurosurg Psychiatry, 511, pp.966~976 (1988)
  91. Takahama H, "Stereotactic aspiration in hypertensive pontine hemorrhage: comparative study with conservative therapy", No Shinkei Geka, 17, pp.733~739 (1989)
  92. Mendelow AD, "Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial", Lancet, 365, pp.387~397 (2005)
  93. Mendelow AD, "Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial", Lancet, 382, pp.397~408 (2013)
  94. Fung C, "Decompressive hemicraniectomy in patients with supratentorial intracerebral hemorrhage", Stroke, 43, pp.3207~3211 (2012)
  95. Hayes SB, "Retrospective comparison of craniotomy and decompressive craniectomy for surgical evacuation of nontraumatic, supratentorial intracerebral hemorrhage", Neurosurg Focus, 34, pp.E3~ (2013)
  96. Heuts SG, "Decompressive hemicraniectomy without clot evacuation in dominant-sided intracerebral hemorrhage with ICP crisis", Neurosurg Focus, 34, pp.E4~ (2013)
  97. Takeuchi S, "Decompressive hemicraniectomy for spontaneous intracerebral hemorrhage", Neurosurg Focus, 34, pp.E5~ (2013)
  98. Auer LM, "Endoscopic surgery versus medical treatment for spontaneous intracerebral hematoma: a randomized study", J Neurosurg, 70, pp.530~535 (1989)
  99. Morgan T, "Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation (MISTIE) clinical trial", Acta Neurochir Suppl, 105, pp.147~151 (2008)
  100. Mould WA, "Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema", Stroke, 44, pp.627~634 (2013)
  101. Wang WZ, "Minimally invasive craniopuncture therapy vs. conservative treatment for spontaneous intracerebral hemorrhage: results from a randomized clinical trial in China", Int J Stroke, 4, pp.11~16 (2009)
  102. Gregson BA, "Individual patient data subgroup meta-analysis of surgery for spontaneous supratentorial intracerebral hemorrhage", Stroke, 43, pp.1496~1504 (2012)
  103. Morgenstern LB, "Rebleeding leads to poor outcome in ultra-early craniotomy for intracerebral hemorrhage", Neurology, 56, pp.1294~1299 (2001)
  104. Hallevi H, "Intraventricular hemorrhage: Anatomic relationships and clinical implications", Neurology, 70, pp.848~852 (2008)
  105. Morgan T, "Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial", Acta Neurochir Suppl, 105, pp.217~220 (2008)
  106. Naff N, "Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial", Stroke, 42, pp.3009~3016 (2011)
  107. Bai Y, "A prospective, randomized, single-blinded trial on the effect of early rehabilitation on daily activities and motor function of patients with hemorrhagic stroke", J Clin Neurosci, 19, pp.1376~1379 (2012)
  108. Cumming TB, "Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial", Stroke, 42, pp.153~158 (2011)

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