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비알코올성 지방간질환의 병발 질환

Comorbid Diseases in Nonalcoholic fatty liver disease

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참고문헌

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초록

NAFLD는 인슐린 저항성과 밀접한 관련이 있고, 대사증후군의 간내 발현으로 발생 빈도가 증가하는 가운데 다른 대사성 전신질환들과 연관이 깊다는 연구들을 통해 단순히 만성 간질환으로 국한시키기 보다는 전신적 대사질환으로 인식을 새롭게 해야 한다. NAFLD 자체가 간경변증이나 간세포암 같은 진행성 간 질환으로 발전될 수 있으며 많은 전신적 대사 질환의 진행 및 악화 요소로 작용한다는 사실에 주목하여 현재까지 불명확한 병태생리에 관한 연구들이 필요할 것으로 생각된다.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a wide spectrum of diseases that are ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. NAFLD has been recognized as a hepatic feature of metabolic syndrome linked with insulin resistance. Recent evidence supports that NAFLD is associated with numerous systemic diseases such as cardiovascular disease, chronic kidney disease, type 2 diabetes, obesity, metabolic syndrome. Therefore, NAFLD should be newly considered not only an liver specific disease, but also early mediator of systemic metabolic disease. The underlying mechanism and pathogenesis of harmful effect of NAFLD on other medical disorders are yet to be fully understood and major questions remain that must be solved to decreased morbidity and mortality from the spectrum of NAFLD. So further research is needed for future therapeutic strategies of NAFLD. This review focuses on the relationship between NAFLD and various comorbid disease.

참고문헌 (49)

  1. Park SH, "Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults", J Gastroenterol Hepatol, 21, pp.138~143 (2006)
  2. Brea A, "Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study", Arterioscler Thromb Vasc Biol, 25, pp.1045~1050 (2005)
  3. Fracanzani AL, "Carotid artery intima-media thickness in nonalcoholic fatty liver disease", Am J Med, 121, pp.72~78 (2008)
  4. Targher G, "Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation", Diabetes Care, 27, pp.2498~2500 (2004)
  5. Villanova N, "Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease", Hepatology, 42, pp.473~480 (2005)
  6. Davignon J, "Role of endothelial dysfunction in atherosclerosis", Circulation, 109(23 Suppl 1), pp.III27~III32 (2004)
  7. Schindhelm RK, "Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 diabetes mellitus and cardiovascular disease", Diabetes Metab Res Rev, 22, pp.437~443 (2006)
  8. Kim DH, "Non-alcoholic fatty liver disease (NAFLD) as a risk factor of coronary heart disease; relation of NAFLD to coronary artery calcification score by multi- detector computed tomography", The 43rd Annual Meeting of the European Association for the Study of the Liver Milan (2008)
  9. Pitsavos C, "Risk stratification of apolipoprotein B, apolipoprotein A1, and apolipoprotein B", AI ratio on the prevalence of the metabolic syndrome: the ATTICA study, 2008, pp.59, 335~341
  10. Lind L, "The apolipoprotein B", AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men, 2006, pp.26, 406~410
  11. Holme I, "Relationships between lipoprotein components and risk of myocardial infarction: age, gender and short versus longer follow-up periods in the Apolipoprotein MOrtality RISk study (AMORIS)", J Intern Med, 264, pp.30~38 (2008)
  12. 이지애, "전당뇨병 환자에서 ApoB", ApoA-I Ratio와 비알코올성 지방간과의 연관성, 2010, pp.78(2), 191~197[DOI]
  13. Targher G, "Increased prevalence of cardiovascular disease in Type 2 diabetic patients with nonalcoholic fatty liver disease", Diabet Med, 23, pp.403~409 (2006)
  14. Yki-Järvinen H, "The fatty liver and insulin resistance", Curr Mol Med, 5, pp.287~295 (2005)
  15. McCullough AJ, "Pathophysiology of nonalcoholic steatohepatitis", J Clin Gastroenterol, 40(Suppl 1), pp.S17~S29 (2006)
  16. Marchesini G, "Nonalcoholic fatty liver disease and the metabolic syndrome", Curr Opin Lipidol, 16, pp.421~427 (2005)
  17. Neuschwander-Teri BA, "Nonalcoholic steatohepatitis and the metabolic syndrome", Am J Med Sci, 330, pp.326~335 (2005)
  18. Matsuzawa Y, "Adiponectin and metabolic syndrome", Arterioscler Thromb Vasc Biol, 24, pp.29~33 (2004)
  19. Pischon T, "Plasma adiponectin levels and risk of myocardial infarction in men", JAMA, 291, pp.1730~1737 (2004)
  20. Gross JL, "Diabetic nephropathy: diagnosis, prevention, and treatment", Diabetes Care, 28, pp.164~176 (2005)
  21. Satchell SC, "What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?", Diabetologia, 51, pp.714~725 (2008)
  22. Chen J, "The metabolic syndrome and chronic kidney disease in U.S. adults", Ann Intern Med, 140, pp.167~174 (2004)
  23. Lin CC, "Microalbuminuria and the metabolic syndrome and its components in the Chinese population", Eur J Clin Invest, 37, pp.783~790 (2007)
  24. Targher G, "Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease", J Am Soc Nephrol, 19, pp.1564~1570 (2008)
  25. Chang Y, "Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men", Metabolism, 57, pp.569~576 (2008)
  26. Hwang ST, "Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes", Intern Med J, 40, pp.437~442 (2010)
  27. Wolf G, "Leptin and renal disease", Am J Kidney Dis, 39, pp.1~11 (2002)
  28. Kambham N, "Obesity-related glomerulopathy: an emerging epidemic", Kidney Int, 59, pp.1498~1509 (2001)
  29. Asselah T, "Steatosis in chronic hepatitis C: why does it really matter?", Gut, 55, pp.123~130 (2006)
  30. Conjeevaram HS, "Race, insulin resistance and hepatic steatosis in chronic hepatitis C", Hepatology, 45, pp.80~87 (2007)
  31. Adinolfi LE, "Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity", Hepatology, 33, pp.1358~1364 (2001)
  32. Bugianesi E, "Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis", Hepatology, 44, pp.1648~1655 (2006)
  33. Gabriel A, "Hepatocyte steatosis in HCV patients promotes fibrosis by enhancing TGF-beta liver expression", Hepatol Res, 38, pp.141~146 (2008)
  34. Piche T, "The severity of liver fibrosis is associated with high leptin levels in chronic hepatitis C", J Viral Hepat, 11, pp.91~96 (2004)
  35. Adams LA, "The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies", J Hepatol, 42, pp.132~138 (2005)
  36. Matteoni CA, "Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity", Gastroenterology, 116, pp.1413~1419 (1999)
  37. Ekstedt M, "Long-term follow-up of patients with NAFLD and elevated liver enzymes", Hepatology, 44, pp.865~873 (2006)
  38. Marchesini G, "Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome", Hepatology, 37, pp.917~923 (2003)
  39. Hamaguchi M, "The metabolic syndrome as a predictor of nonalcoholic fatty liver disease", Ann Intern Med, 143, pp.722~728 (2005)
  40. Marchesini G, "Nonalcoholic fatty liver disease: a feature of the metabolic syndrome", Diabetes, 50, pp.1844~1850 (2001)
  41. Neuschwander-Tetri BA, "Interim results of a pilot study demonstrating the early effect of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferase, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis", J Heptol, 38, pp.434~440 (2003)
  42. Angulo P, "Nonalcoholic fatty liver disease", N Engl J Med, 346, pp.1221~1231 (2002)
  43. Dixon JB, "Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese", Gastroenterology, 121, pp.91~100 (2001)
  44. Adams LA, "Nonalcoholic fatty liver disease increase risk of death among patient with diabetes: a community- based cohort study", Am J Gastroenterol, 105, pp.1567~1573 (2010)
  45. Seppälä-Lindroos A, "Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men", J Clin Endocrinol Metab, 87, pp.3023~3028 (2002)
  46. Struben VM, "Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds", Am J Med, 108, pp.9~13 (2000)
  47. Friis-Liby I, "High prevalence of metabolic complications in patients with non-alcoholic fatty liver disease", Scand J Gastroenterol, 39, pp.864~869 (2004)
  48. Fan JG, "Effects of nonalcoholic fatty liver disease on the development of metabolic disorders", J Gastroenterol Hepatol, 22, pp.1086~1091 (2007)
  49. Shibata M, "Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men", Diabetes Care, 30, pp.2940~2944 (2007)

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