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Photodynamic Therapy for Esophageal Cancer

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초록

Photodynamic therapy, a curative local treatment for esophageal squamous cell carcinoma, involves a photosensitizing drug(photosensitizer) with affinity for tumors and a photodynamic reaction triggered by laser light. Previously, photodynamic therapywas used to treat superficial esophageal squamous cell carcinoma judged to be difficult to undergo endoscopic resection. Recently,photodynamic therapy has mainly been performed for local failure after chemoradiotherapy. Although surgery is the most promisingtreatment for local failure after chemoradiotherapy, its morbidity and mortality rates are high. Endoscopic resection is feasible forlocal failure after chemoradiotherapy but requires advanced skills, and its indication is limited to within the submucosal layer bydepth. Photodynamic therapy is less invasive than surgery and has a wider indication than endoscopic resection. Porfimer sodium(a first-generation photosensitizer) causes a high frequency of side effects related to photosensitivity and requires the long-termsun-shade period. Talaporfin (a second-generation photosensitizer) requires a much shorter sun-shade period than porfimersodium. Photodynamic therapy will profoundly change treatment strategies for local failure after chemoradiotherapy.

Abstract

Photodynamic therapy, a curative local treatment for esophageal squamous cell carcinoma, involves a photosensitizing drug(photosensitizer) with affinity for tumors and a photodynamic reaction triggered by laser light. Previously, photodynamic therapywas used to treat superficial esophageal squamous cell carcinoma judged to be difficult to undergo endoscopic resection. Recently,photodynamic therapy has mainly been performed for local failure after chemoradiotherapy. Although surgery is the most promisingtreatment for local failure after chemoradiotherapy, its morbidity and mortality rates are high. Endoscopic resection is feasible forlocal failure after chemoradiotherapy but requires advanced skills, and its indication is limited to within the submucosal layer bydepth. Photodynamic therapy is less invasive than surgery and has a wider indication than endoscopic resection. Porfimer sodium(a first-generation photosensitizer) causes a high frequency of side effects related to photosensitivity and requires the long-termsun-shade period. Talaporfin (a second-generation photosensitizer) requires a much shorter sun-shade period than porfimersodium. Photodynamic therapy will profoundly change treatment strategies for local failure after chemoradiotherapy.

참고문헌 (28)

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