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KERD
논문KCI 등재

국내에서의 췌장이식의 경과

Progress in Pancreas Transplantation in Korea

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초록

국내 단일 기관으로서 100예 이상의 성공적인 췌장 이식 경험을 발표함으로써 우리나라도 단연 췌장이식 분야에서 권위 있는 국가가 되었다. 이것을 계기로 신장이나 간 장기 외에 췌장 등을 포함한 장기 공여자 수를 확대하기 위해 정부 차원의 지원과 홍보가 필요하다. 또한 췌장 이식에 대한 풍부한 의료 경험을 공유하기 위한 네트워크 확립이 필요할 것이다.

Abstract

Pancreas transplantation is the most effective cure for type I diabetes because it is able to restore normal glucose homeostasis. Over the last 2 decades, improvements in immunosuppressive therapy have been paralleled by a marked decrease in surgical complications, by superior antimicrobial prophylaxis and therapy, and by better techniques for diagnosing and treating pancreas graft rejection. The result has been a steady increase in the number of pancreas transplants. However, differently from heart, lung and liver transplantation, pancreas transplantation cannot be considered a life-saving procedure and the advantages in the long term should be carefully considered and balanced with the morbidity and mortality associated to the surgical procedure and the side-effect of immunosuppression. (Korean J Med 2011;80:164-166)

참고문헌 (9)

  1. Gruessner AC, "Pancreas transplantation in the United States: a review", Curr Opin Organ Transplant, 15, pp.93~101 (2010)
  2. 한덕종, "국내 단일기관에서 시행한 췌장이식의 임상적인 결과", 대한내과학회지, 80(2), pp.167~178 (2011), 대한내과학회
  3. Remuzzi G, "Pancreas and kidney", pancreas transplants: experimental medicine or real improvement, 1994, pp.343, 27~31
  4. Fioretto P, "Reversal of lesions of diabetic nephropathy after pancreas transplantation", N Engl J Med, 339, pp.69~75 (1998)
  5. The Diabetes Control and Complications Trial Research Group, "The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus", N Engl J Med, 329, pp.977~986 (1993)
  6. Johansson BL, "Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type I", J Clin Endocrinol Metab, 77, pp.976~981 (1993)
  7. Gruessner AC, "Pancreas transplant outcomes for United States (US) cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR), In Clinical Transplants 2008", pp.45~56 (2009), UCLA Tissue Typing Laboratory
  8. Dew MA, "Does transplantation produce quality of life benefits? A quantitative analysis of the literature", Transplantation, 64, pp.1261~1273 (1997)
  9. Luzi L, "Metabolic effects of successful intraportal islet transplantation in insulin-dependent diabetes mellitus", J Clin Invest, 97, pp.2611~2618 (1996)

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