영양, 대사 및 감염에 미치는 프로톤펌프억제제의 영향: Safe 측면
The Effect of Proton Pump Inhibitors on Nutrition, Metabolism, Infection and Small Intestinal Bacterial Overgrowth: Safe Perspective
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초록
영양, 대사 및 감염에 미치는 연구결과들을 보았을 때 PPI 장기사용은 이와 같은 측면에서 보면 비교적 안전하다고 할 수 있다. PPI 사용이 절대적 적응증이 된다면 아직까지는 이와 같은 부작용을 고려하여 PPI 사용을 저해할 만한 근거는 부족하겠다. 하지만 PPI 장기사용에 따른 부작용에 대한 인지는 PPI 사용에 있어 적절한 적응증의 선택, 효과를 나타내는 최소용량 및 적절한 기간에 대한 중요성을 한 번 더 인식할 수 있다는 점에서 매우 의미 있는 일이다. 또한, 이론적으로 가능한 부작용에 대하여 임상적 고위험군 선정에 대한 추후 연구가 필요하다고 하겠다.
Abstract
Proton pump inhibitors (PPIs) have been widely used to treat patients with acid-related disorders because they are perceived to be safe and effective. However, they have the potential for side effects. Many studies have examined the side effects of long-term PPI exposure. We review the side effects of long-term PPIs, focusing on nutrition, metabolism, and infection. (Korean J Med 2011;81:11-16)
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