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Intracranial Atherosclerosis: From Microscopy to High-Resolution Magnetic Resonance Imaging

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초록

Intracranial atherosclerosis is one of the leading causes of ischemic stroke and occurs more commonly in patients of Asian, African or Hispanic origin than in Caucasians. Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. However, the pathological validation of HRMRI signal characteristics remains a key step to depict the plaque components and vulnerability in intracranial atherosclerotic lesions. The purpose of this review is to describe the histological features of intracranial atherosclerosis and to state current evidences regarding the validation of MR vessel wall imaging with histopathology.

Abstract

Intracranial atherosclerosis is one of the leading causes of ischemic stroke and occurs more commonly in patients of Asian, African or Hispanic origin than in Caucasians. Although the histopathology of intracranial atherosclerotic disease resembles extracranial atherosclerosis, there are some notable differences in the onset and severity of atherosclerosis. Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. However, the pathological validation of HRMRI signal characteristics remains a key step to depict the plaque components and vulnerability in intracranial atherosclerotic lesions. The purpose of this review is to describe the histological features of intracranial atherosclerosis and to state current evidences regarding the validation of MR vessel wall imaging with histopathology.

참고문헌 (94)

  1. 김종성, "Research on Intracranial Atherosclerosis from the East and West: Why Are the Results Different?", 대한뇌졸중학회지, 16(3), pp.105~113 (2014), 대한뇌졸중학회[DOI]
  2. Qureshi AI, "Intracranial atherosclerotic disease: an update", Ann Neurol, 66, pp.730~738 (2009)
  3. Komotar RJ, "Update on the natural history of intracranial atherosclerotic disease: a critical review", World J Radiol, 2, pp.166~171 (2010)
  4. Suri MF, "Epidemiology of intracranial stenosis", J Neuroimaging, 19(Suppl 1), pp.11S~16S (2009)
  5. Mathur KS, "Atherosclerosis in india. An autopsy study of the aorta and the coronary, cerebral, renal, and pulmonary arteries", Circulation, 24, pp.68~75 (1961)
  6. Mathur KS, "Correlation of the extent and severity of atherosclerosis in the coronary and cerebral arteries", Circulation, 27, pp.929~934 (1963)
  7. Baker AB, "Cerebrovascular disease. I. The large arteries of the circle of willis", Neurology, 9, pp.321~332 (1959)
  8. Sadoshima S, "Cerebral and aortic atherosclerosis in Hisayama, Japan", Atherosclerosis, 36, pp.117~126 (1980)
  9. Bouissou H, "Age related changes of the middle cerebral artery and a comparison with the radial and coronary artery", Angiology, 26, pp.257~268 (1975)
  10. Gorelick PB, "Distribution of atherosclerotic cerebrovascular lesions. Effects of age, race, and sex", Stroke, 24(12Suppl 1), pp.I16~I19 (1993)
  11. Kim JS, "Location of cerebral atherosclerosis:why is there a difference between east and west?", Int J Stroke, pii, pp.1747493016~ (2016)
  12. Kim JS, "Risk factors and stroke mechanisms in atherosclerotic stroke: intracranial compared with extracranial and anterior compared with posterior circulation disease", Stroke, 43, pp.3313~3318 (2012)
  13. Kim YD, "Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis", Neuroepidemiology, 32, pp.201~207 (2009)
  14. Lei C, "Risk factors and clinical outcomes associated with intracranial and extracranial atherosclerotic stenosis acute ischemic stroke", J Stroke Cerebrovasc Dis, 23, pp.1112~1117 (2014)
  15. Resch JA, "A comparative study of cerebral atherosclerosis in a Japanese and Minnesota population", J Atheroscler Res, 7, pp.687~693 (1967)
  16. McGarry P, "Cerebral atherosclerosis in New Orleans. Comparisons of lesions by age, sex, and race", Lab Invest, 52, pp.533~539 (1985)
  17. Nakamura M, "Cerebral atherosclerosis in Japanese. I. Age related to atherosclerosis", Stroke, 2, pp.400~408 (1971)
  18. Solberg LA, "Distribution of cerebral atherosclerosis by geographic location, race, and sex", Lab Invest, 18, pp.604~612 (1968)
  19. D’Armiento FP, "Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classic risk factors for atherosclerosis", Stroke, 32, pp.2472~2479 (2001)
  20. Leung SY, "Pattern of cerebral atherosclerosis in Hong Kong Chinese. Severity in intracranial and extracranial vessels", Stroke, 24, pp.779~786 (1993)
  21. Sacco RL, "Race-ethnicity and determinants of intracranial atherosclerotic cerebral infarction. The Northern Manhattan Stroke Study", Stroke, 26, pp.14~20 (1995)
  22. Leng X, "Evaluating intracranial atherosclerosis rather than intracranial stenosis", Stroke, 45, pp.645~651 (2014)
  23. Niccoli G, "Advances in mechanisms, imaging and management of the unstable plaque", Atherosclerosis, 233, pp.467~477 (2014)
  24. Nam HS, "Association of aortic plaque with intracranial atherosclerosis in patients with stroke", Neurology, 67, pp.1184~1188 (2006)
  25. Kronzon I, "Aortic atherosclerotic disease and stroke", Circulation, 114, pp.63~75 (2006)
  26. Bentzon JF, "Mechanisms of plaque formation and rupture", Circ Res, 114, pp.1852~1866 (2014)
  27. Bae HJ, "Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries", Cerebrovasc Dis, 21, pp.112~119 (2006)
  28. Ritz K, "Cause and mechanisms of intracranial atherosclerosis", Circulation, 130, pp.1407~1414 (2014)
  29. Ross R., "Atherosclerosis--an inflammatory disease", N Engl J Med, 340, pp.115~126 (1999)
  30. Portanova A, "Intracranial vasa vasorum: insights and implications for imaging", Radiology, 267, pp.667~679 (2013)
  31. Wolinsky H, "Nature of species differences in the medial distribution of aortic vasa vasorum in mammals", Circ Res, 20, pp.409~421 (1967)
  32. Geiringer E, "Intimal vascularization and atherosclerosis", J Pathol Bacteriol, 63, pp.201~211 (1951)
  33. Connolly ES Jr, "Immunohistochemical detection of intracranial vasa vasorum: a human autopsy study", Neurosurgery, 38, pp.789~793 (1996)
  34. Aydin F, "Do human intracranial arteries lack vasa vasorum? A comparative immunohistochemical study of intracranial and systemic arteries", Acta Neuropathol, 96, pp.22~28 (1998)
  35. Kwon TG, "The vasa vasorum in atherosclerosis:the vessel within the vascular wall", J Am Coll Cardiol, 65, pp.2478~2480 (2015)
  36. Finn AV, "Coronary plaque neovascularization and hemorrhage: a potential target for plaque stabilization?", JACC Cardiovasc Imaging, 3, pp.41~44 (2010)
  37. Maiellaro K, "The role of the adventitia in vascular inflammation", Cardiovasc Res, 75, pp.640~648 (2007)
  38. Ritman EL, "The dynamic vasa vasorum", Cardiovasc Res, 75, pp.649~658 (2007)
  39. Dunmore BJ, "Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques", J Vasc Surg, 45, pp.155~159 (2007)
  40. Xu J, "Vasa vasorum in atherosclerosis and clinical significance", Int J Mol Sci, 16, pp.11574~11608 (2015)
  41. MacAlpin RN, "Human coronary artery size during life. A cinearteriographic study", Radiology, 108, pp.567~576 (1973)
  42. Gabrielsen TO, "Normal size of the internal carotid, middle cerebral and anterior cerebral arteries", Acta Radiol Diagn (Stockh), 10, pp.1~10 (1970)
  43. Funabashi N, "Coronary artery: quantitative evaluation of normal diameter determined with electron-beam CT compared with cine coronary angiography initial experience", Radiology, 226, pp.263~271 (2003)
  44. Krejza J, "Carotid artery diameter in men and women and the relation to body and neck size", Stroke, 37, pp.1103~1105 (2006)
  45. Gutierrez J, "A quantitative perspective to the study of brain arterial remodeling of donors with and without HIV in the Brain Arterial Remodeling Study (BARS)", Front Physiol, 5, pp.56~ (2014)
  46. Waller BF, "Anatomy, histology, and pathology of coronary arteries:a review relevant to new interventional and imaging techniques--part I", Clin Cardiol, 15, pp.451~457 (1992)
  47. Pu Y, "Natural history of intracranial atherosclerotic disease", Front Neurol, 5, pp.125~ (2014)
  48. Finn AV, "Concept of vulnerable", unstable plaque, 2010, pp.30, 1282~1292
  49. Naghavi M, "From vulnerable plaque to vulnerable patient:a call for new definitions and risk assessment strategies: part I", Circulation, 108, pp.1664~1672 (2003)
  50. Qureshi AI, "Intracranial atherosclerosis", Lancet, 383, pp.984~998 (2014)
  51. Velican D, "Method dependent limits in a study on the natural history of coronary and cerebral atherosclerosis", Med Interne, 20, pp.215~229 (1982)
  52. Denswil NP, "Atherosclerosis in the circle of willis: spatial differences in composition and in distribution of plaques", Atherosclerosis, 251, pp.78~84 (2016)
  53. Teng Z, "Plaque hemorrhage in carotid artery disease: pathogenesis, clinical and biomechanical considerations", J Biomech, 47, pp.847~858 (2014)
  54. Derksen WJ, "Different stages of intraplaque hemorrhage are associated with different plaque phenotypes:a large histopathological study in 794 carotid and 276femoral endarterectomy specimens", Atherosclerosis, 218, pp.369~377 (2011)
  55. Harteveld AA, "Quantitative intracranial atherosclerotic plaque characterization at 7T MRI: an ex vivo study with histologic validation", AJNR Am J Neuroradiol, 37, pp.802~810 (2016)
  56. Chen XY, "Middle cerebral artery atherosclerosis: histological comparison between plaques associated with and not associated with infarct in a postmortem study", Cerebrovasc Dis, 25, pp.74~80 (2008)
  57. Xu WH, "Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance", Ann Neurol, 71, pp.195~198 (2012)
  58. Chen XY, "Intracranial artery calcification: a newly identified risk factor of ischemic stroke", J Neuroimaging, 17, pp.300~303 (2007)
  59. Xiaohong Wu, "Intracranial Artery Calcifcation and Its Clinical Signifcance", Journal of Clinical Neurology, 12(3), pp.253~261 (2016), 대한신경과학회[DOI]
  60. Wu XH, "High extent of intracranial carotid artery calcification is associated with downstream microemboli in stroke patients", J Stroke Cerebrovasc Dis, 26, pp.442~447 (2017)
  61. Chen XY, "The frequency and determinants of calcification in intracranial arteries in Chinese patients who underwent computed tomography examinations", Cerebrovasc Dis, 21, pp.91~97 (2006)
  62. Virmani R, "Histopathology of carotid atherosclerotic disease", Neurosurgery, 59(5Suppl 3), pp.S219~S227 (2006)
  63. Labadzhyan A, "Histopathologic evaluation of basilar artery atherosclerosis", J Neurol Sci, 307, pp.97~99 (2011)
  64. Stary HC, "A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association", Circulation, 92, pp.1355~1374 (1995)
  65. Mazighi M, "Autopsy prevalence of intracranial atherosclerosis in patients with fatal stroke", Stroke, 39, pp.1142~1147 (2008)
  66. Gutierrez J, "A pathological perspective on the natural history of cerebral atherosclerosis", Int J Stroke, 10, pp.1074~1080 (2015)
  67. Kasner SE, "Predictors of ischemic stroke in the territory of a symptomatic intracranial arterial stenosis", Circulation, 113, pp.555~563 (2006)
  68. Wang Y, "Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study", Stroke, 45, pp.663~669 (2014)
  69. Dieleman N, "Imaging intracranial vessel wall pathology with magnetic resonance imaging: current prospects and future directions", Circulation, 130, pp.192~201 (2014)
  70. van der Kolk AG, "Intracranial vessel wall imaging at 7.0-T MRI", Stroke, 42, pp.2478~2484 (2011)
  71. Kim YS, "The advantage of high-resolution MRI in evaluating basilar plaques:a comparison study with MRA", Atherosclerosis, 224, pp.411~416 (2012)
  72. Li ML, "Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T", Atherosclerosis, 204, pp.447~452 (2009)
  73. Xu WH, "Plaque distribution of stenotic middle cerebral artery and its clinical relevance", Stroke, 42, pp.2957~2959 (2011)
  74. Natori T, "Evaluating middle cerebral artery atherosclerotic lesions in acute ischemic stroke using magnetic resonance T1-weighted 3-dimensional vessel wall imaging", J Stroke Cerebrovasc Dis, 23, pp.706~711 (2014)
  75. Young Jun Choi, "Vessel Wall Imaging of the Intracranial and Cervical Carotid Arteries", 대한뇌졸중학회지, 17(3), pp.238~255 (2015), 대한뇌졸중학회
  76. Yuan C, "In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques", Circulation, 104, pp.2051~2056 (2001)
  77. Narumi S, "Predicting carotid plaque characteristics using quantitative color-coded T1-weighted MR plaque imaging:correlation with carotid endarterectomy specimens", AJNR Am J Neuroradiol, 35, pp.766~771 (2014)
  78. Cai J, "In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology", Circulation, 112, pp.3437~3444 (2005)
  79. den Hartog AG, "Current status of clinical magnetic resonance imaging for plaque characterisation in patients with carotid artery stenosis", Eur J Vasc Endovasc Surg, 45, pp.7~21 (2013)
  80. Chen XY, "High signal on T1 sequence of magnetic resonance imaging confirmed to be intraplaque haemorrhage by histology in middle cerebral artery", Int J Stroke, 9, pp.E19~ (2014)
  81. Yang WJ, "Postmortem study of validation of low signal on fat-suppressed T1-weighted magnetic resonance imaging as marker of lipid core in middle cerebral artery atherosclerosis", Stroke, 47, pp.2290~2304 (2016)
  82. Jiang Y, "Ex-vivo imaging and plaque type classification of intracranial atherosclerotic plaque using high resolution MRI", Atherosclerosis, 249, pp.10~16 (2016)
  83. Majidi S, "Intracranial-derived atherosclerosis assessment:an in vitro comparison between virtual histology by intravascular ultrasonography, 7T MRI, and histopathologic findings", AJNR Am J Neuroradiol, 34, pp.2259~2264 (2013)
  84. van der Kolk AG, "Imaging the intracranial atherosclerotic vessel wall using 7T MRI: initial comparison with histopathology", AJNR Am J Neuroradiol, 36, pp.694~701 (2015)
  85. Mossa-Basha M, "Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes", Stroke, 46, pp.1567~1573 (2015)
  86. Xu WH, "In vivo highresolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis", Atherosclerosis, 212, pp.507~511 (2010)
  87. Millon A, "Clinical and histological significance of gadolinium enhancement in carotid atherosclerotic plaque", Stroke, 43, pp.3023~3028 (2012)
  88. Wasserman BA, "Advanced contrast-enhanced MRI for looking beyond the lumen to predict stroke: building a risk profile for carotid plaque", Stroke, 41(10 Suppl), pp.S12~S16 (2010)
  89. Kerwin WS, "Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study", Radiology, 241, pp.459~468 (2006)
  90. Ryu CW, "Gadolinium enhancement of atherosclerotic plaque in the middle cerebral artery: relation to symptoms and degree of stenosis", AJNR Am J Neuroradiol, 35, pp.2306~2310 (2014)
  91. Natori T, "Intracranial plaque characterization in patients with acute ischemic stroke using pre- and post-contrast three-dimensional magnetic resonance vessel wall imaging", J Stroke Cerebrovasc Dis, 25, pp.1425~1430 (2016)
  92. Qiao Y, "Intracranial plaque enhancement in patients with cerebrovascular events on high-spatial-resolution MR images", Radiology, 271, pp.534~542 (2014)
  93. Skarpathiotakis M, "Intracranial atherosclerotic plaque enhancement in patients with ischemic stroke", AJNR Am J Neuroradiol, 34, pp.299~304 (2013)
  94. Turan TN, "Intracranial atherosclerosis: correlation between in-vivo 3T high resolution MRI and pathology", Atherosclerosis, 237, pp.460~463 (2014)

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