신종플루 백신 접종 후 발생한 전신성 홍반성 루푸스 1예
A Case of Systemic Lupus Erythematosus Occurring after H1N1 Influenza Vaccination
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초록
저자들은 기존 병력이 없던 17세 여자 환자가 신종플루 백신 접종 후 루푸스가 발생하여 치료 후 호전된 첫 증례를 경험하여 보고하는 바이다.
Abstract
The recent worldwide outbreak of H1N1 has led to the universal administration of H1N1 influenza vaccination, including in South Korea. Several complications have been reported with use of H1N1 influenza vaccine, but systemic lupus erythematosus (SLE) has not been reported as a complication until now. Here, we report a case of SLE occurrence after H1N1 influenza vaccination. A 17-year-old girl who had not been diagnosed with SLE was hospitalized with fever, myalgia, and arthralgia after H1N1 influenza vaccination. Laboratory tests revealed increased levels of antinuclear antibody and anti-ds-DNA antibody, and decreased levels of C3 and C4 as well as proteinuria. The pathological findings confirmed a diagnosis of lupus nephritis. The patient was treated with high-dose corticosteroid and hydroxychloroquine. This is the first report of SLE following H1N1 influenza vaccination in South Korea.
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