병리조직학적으로 진단된 부분적 자발 퇴행 간암 환자 1예
Pathologically Confirmed Spontaneous Partial Regression of Hepatocellular Carcinoma
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초록
Spontaneous regression of hepatocellular carcinoma (HCC) is extremely rare, and dozens of cases have been reported in theliterature. In this report, we present a case of pathologically confirmed HCC that partially regressed without medical intervention. A54-year-old Korean male with chronic hepatitis B had a hepatic mass detected by abdominal ultrasonography during a routine visit. A clinical diagnosis of HCC was made after measuring serum α-fetoprotein levels followed by dynamic computedtomography and magnetic resonance imaging. The patient delayed surgical resection; however, after 5 months, the size of theHCC decreased from 3.2 to 1.0 cm in diameter without any treatment. At that time the mass was surgically resected. Histopathologyconfirmed that the hepatic mass was consistent with partially regressed HCC and showed more intra- and peri-tumoral lymphocytesconsisting of greater CD4+ T cell infiltration than what is normally seen in resected HCC.
Abstract
Spontaneous regression of hepatocellular carcinoma (HCC) is extremely rare, and dozens of cases have been reported in theliterature. In this report, we present a case of pathologically confirmed HCC that partially regressed without medical intervention. A54-year-old Korean male with chronic hepatitis B had a hepatic mass detected by abdominal ultrasonography during a routine visit. A clinical diagnosis of HCC was made after measuring serum α-fetoprotein levels followed by dynamic computedtomography and magnetic resonance imaging. The patient delayed surgical resection; however, after 5 months, the size of theHCC decreased from 3.2 to 1.0 cm in diameter without any treatment. At that time the mass was surgically resected. Histopathologyconfirmed that the hepatic mass was consistent with partially regressed HCC and showed more intra- and peri-tumoral lymphocytesconsisting of greater CD4+ T cell infiltration than what is normally seen in resected HCC.
참고문헌 (10)
- "Korea National Health and Nutrition Examination Survey", ~ (2011)
- Okuda K, "Natural history of hepatocellular carcinoma and prognosis in relation to treatment: study of 850 patients", Cancer, 56, pp.918~928 (1985)
- Oquinena S, "Spontaneous regression of hepatocellular carcinoma: a systematic review", Eur J Gastroenterol Hepatol, 21, pp.254~257 (2009)
- Bruix J, "American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update", Hepatology, 53, pp.1020~1022 (2011)
- Wada Y, "Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration", Hepatology, 27, pp.407~414 (1998)
- Park HS, "Hepatocellular carcinoma with massive lymphoid infiltration: a regressing phenomenon", Pathol Res Pract, 205, pp.648~652 (2009)
- Homma S, "Antitumour activity mediated by CD4+ cytotoxic T lymphocytes against MHC class II-negative mouse hepatocellular carcinoma induced by dendritic cell vaccine and interleukin-12", Immunology, 115, pp.451~461 (2005)
- Fu J, "Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma", Hepatology, 58, pp.139~149 (2013)
- Lee HS, "Recurrent hepatocellular carcinoma after spontaneous regression", J Gastroenterol, 35, pp.552~556 (2000)
- Sasaki T, "Management considerations for purported spontaneous regression of hepatocellular carcinoma: a case report", Case Rep Gastroenterol, 7, pp.147~152 (2013)