류마티스 관절염 환자에서 심장 조직 검사로 확진된 아밀로이드단백 A 심장 아밀로이드증
Systemic Amyloid Protein a Amyloidosis Involving the Heart in a Patient with Rheumatoid Arthritis
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초록
Amyloidosis can be identified by the deposition of amyloid fibrils in biopsy specimens from multiple organs, including the heart,kidney, skin, and bowel. Systemic amyloid protein A amyloidosis (AA amyloidosis) is commonly associated with chronic inflammatorydiseases or chronic infectious conditions. Cardiac involvement in AA amyloidosis is found in < 1% of reported cases. Here, we report a case of cardiac AA amyloidosis confirmed by heart biopsy in a 54-year-old-female with a medical history of rheumatoidarthritis and stage 4 chronic kidney disease due to renal amyloidosis. She had suffered from progressive aggravation ofdyspnea for 2 years. Infiltrative disease involving the heart was suspected by echocardiography, and the patient was diagnosed withAA amyloidosis involving the heart by cardiac biopsy. This is a rare case of cardiac involvement in a patient with systemic AA amyloidosisassociated with rheumatoid arthritis.
Abstract
Amyloidosis can be identified by the deposition of amyloid fibrils in biopsy specimens from multiple organs, including the heart,kidney, skin, and bowel. Systemic amyloid protein A amyloidosis (AA amyloidosis) is commonly associated with chronic inflammatorydiseases or chronic infectious conditions. Cardiac involvement in AA amyloidosis is found in < 1% of reported cases. Here, we report a case of cardiac AA amyloidosis confirmed by heart biopsy in a 54-year-old-female with a medical history of rheumatoidarthritis and stage 4 chronic kidney disease due to renal amyloidosis. She had suffered from progressive aggravation ofdyspnea for 2 years. Infiltrative disease involving the heart was suspected by echocardiography, and the patient was diagnosed withAA amyloidosis involving the heart by cardiac biopsy. This is a rare case of cardiac involvement in a patient with systemic AA amyloidosisassociated with rheumatoid arthritis.
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