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성인에서 장중첩증으로 발현된 과호산구 증후군 1예

Hypereosinophilic Syndrome Presenting as Intussusception in Adults

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초록

Hypereosinophilic syndrome (HES) is characterized by persistent eosinophilia associated with damage to multiple organs. Although the diagnostic criteria for HES include sustained hypereosinophilia for at least 6 months, early initiation of therapy maybe recommended in patients exhibiting HES symptoms. Eosinophilic enteritis has been reported as a cause of intussusception inseveral cases. However, HES as a cause of intussusception has not yet been reported. In the present report, we describe a case ofHES that manifested as jejunojejunal intussusception. Although long-standing hypereosinophilia was not confirmed, the patient requiredeosinophil-lowering therapy for an intestinal obstruction. The patient was treated with systemic corticosteroids, after whichthe symptoms and multiple organ involvement, including intussusception, improved dramatically, as noted on the radiologicalinvestigation. Moreover, surgery was not necessary.

Abstract

Hypereosinophilic syndrome (HES) is characterized by persistent eosinophilia associated with damage to multiple organs. Although the diagnostic criteria for HES include sustained hypereosinophilia for at least 6 months, early initiation of therapy maybe recommended in patients exhibiting HES symptoms. Eosinophilic enteritis has been reported as a cause of intussusception inseveral cases. However, HES as a cause of intussusception has not yet been reported. In the present report, we describe a case ofHES that manifested as jejunojejunal intussusception. Although long-standing hypereosinophilia was not confirmed, the patient requiredeosinophil-lowering therapy for an intestinal obstruction. The patient was treated with systemic corticosteroids, after whichthe symptoms and multiple organ involvement, including intussusception, improved dramatically, as noted on the radiologicalinvestigation. Moreover, surgery was not necessary.

참고문헌 (10)

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  2. Young Woo Jeon, "A Hypereosinophilic Syndrome Presenting as Eosinophilic Colitis", Clinical Endoscopy, 45(4), pp.444~447 (2012), 대한소화기내시경학회
  3. Jung HK, "A case of eosinophilic colitis as a complication of the hypereosinophilic syndrome", Korean J Gastrointest Endosc, 18, pp.417~425 (1998)
  4. Marinis A, "Intussusception of the bowel in adults: a review", World J Gastroenterol, 15, pp.407~411 (2009)
  5. Begos DG, "The diagnosis and management of adult intussusception", Am J Surg, 173, pp.88~ (1997)
  6. Kshirsagar AY, "Eosinophilic enteritis presenting as a rare cause for ileo-ileal intussusception", World J Gastroenterol, 13, pp.6444~6445 (2007)
  7. 신운건, "Eosinophilic Enteritis Presenting as Intussusception in Adult", The Korean Journal of Internal Medicine, 22(1), pp.13~17 (2007), 대한내과학회
  8. Fauci AS, "NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations", Ann Intern Med, 97, pp.78~92 (1982)
  9. Tefferi A, "Hypereosinophilic syndrome and clonal eosinophilia: point-of-care diagnostic algorithm and treatment update", Mayo Clin Proc, 85, pp.158~164 (2010)
  10. Klein NC, "Eosinophilic gastroenteritis", Medicine (Baltimore), 49, pp.299~319 (1970)

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