혈액투석 환자에서 발생한 카포시육종의 Pazopanib 치료 증례
Treatment of a Patient with Kaposi’s Sarcoma Arising during Hemodialysis with the Multikinase Inhibitor Pazopanib
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
현재까지 우리나라에서는 본 증례를 포함해 아주 적은 수의 혈액투석 환자에서의 카포시육종이 보고되었으며, 특히pazopanib을 첫 치료제로 선택한 경우는 보고된 바가 없다. 저자는 림프절병증을 동반한 카포시육종에서 pazopanib 복용 후 피부 병변 크기 감소 및 통증 완화의 치료 효과 있음을 경험하여 보고하고자 한다.
Abstract
Kaposi’s sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in a patient receiving hemodialysis for 7 years. The patient had a history of chronic renal failure due to glomerulonephritis for 20 years. Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity for human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, a multitarget tyrosine kinase inhibitor, is an effective agent for treatment of advanced soft tissue sarcoma. The patient received pazopanib for 6 months investigate its effects on KS. The skin lesions and painful symptoms showed improvement. Further studies are required to determine the mechanism underlying the anticancer action of pazopanib and the pathogenesis of KS.
참고문헌 (10)
- Hayward GS, "Initiation of angiogenic Kaposi's sarcoma lesions", Cancer Cell, 3, pp.1~3 (2003)
- Kaldor JM, "Epidemiological characteristics of Kaposi's sarcoma prior to the AIDS epidemic", Br J Cancer, 70, pp.674~676 (1994)
- Hbid O, "Kaposi's sarcoma in Morocco: a pathological study with immunostaining for human herpesvirus-8 LNA-1", Pathology, 37, pp.288~295 (2005)
- Di Lorenzo G, "Activity and safety of pegylated liposomal doxorubicin as first-line therapy in the treatment of non-visceral classic Kaposi's sarcoma:a multicenter study", J Invest Dermatol, 128, pp.1578~1580 (2008)
- Brambilla L, "Weekly paclitaxel for advanced aggressive classic Kaposi sarcoma: experience in 17 cases", Br J Dermatol, 158, pp.1339~1344 (2008)
- Brambilla L, "Treatment of classical Kaposi's sarcoma with gemcitabine", Dermatology, 202, pp.119~122 (2001)
- Rubegni P, "Thalidomide in the treatment of Kaposi's sarcoma", Dermatology, 215, pp.240~244 (2007)
- Jenner RG, "The molecular pathology of Kaposi's sarcoma-associated herpesvirus", Biochim Biophys Acta, 1602, pp.1~22 (2002)
- Uldrick TS, "Phase II study of bevacizumab in patients with HIV-associated Kaposi's sarcoma receiving antiretroviral therapy", J Clin Oncol, 30, pp.1476~1483 (2012)
- van der Graaf WT, "Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial", Lancet, 379, pp.1879~1886 (2012)