본문 바로가기
KERD
논문KCI 등재

Therapeutic Trends of Cerebrovascular Disease during the COVID-19 Pandemic and Future Perspectives

4

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류신경과학

초록

As of May 2022, there have been more than 400 million cases (including re-infections) of the systemic acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), and nearly 5 million deaths worldwide. Not only has the coronavirus disease 2019 (COVID-19) pandemic been responsible for diagnosis and treatment delays of a wide variety of conditions, and overwhelmed the allocation of healthcare resources, it has impacted the epidemiology and management of cerebrovascular disease. In this narrative review, we summarize the changing paradigms and latest data regarding the complex relationship between COVID-19 and cerebrovascular disease. Paradoxically, although SARS-CoV-2 has been associated with many thrombotic complications—including ischemic stroke—there have been global declines in ischemic stroke and other cerebrovascular diseases. These epidemiologic shifts may be attributed to patient avoidance of healthcare institutions due to fear of contracting the novel human coronavirus, and also related to declines in other transmissible infectious illnesses which may trigger ischemic stroke. Despite the association between SARS-CoV-2 and thrombotic events, there are inconsistent data regarding targeted antithrombotics to prevent venous and arterial events. In addition, we provide recommendations for the conduct of stroke research and clinical trial planning during the ongoing COVID-19 pandemic, and for future healthcare crises.

Abstract

As of May 2022, there have been more than 400 million cases (including re-infections) of the systemic acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), and nearly 5 million deaths worldwide. Not only has the coronavirus disease 2019 (COVID-19) pandemic been responsible for diagnosis and treatment delays of a wide variety of conditions, and overwhelmed the allocation of healthcare resources, it has impacted the epidemiology and management of cerebrovascular disease. In this narrative review, we summarize the changing paradigms and latest data regarding the complex relationship between COVID-19 and cerebrovascular disease. Paradoxically, although SARS-CoV-2 has been associated with many thrombotic complications—including ischemic stroke—there have been global declines in ischemic stroke and other cerebrovascular diseases. These epidemiologic shifts may be attributed to patient avoidance of healthcare institutions due to fear of contracting the novel human coronavirus, and also related to declines in other transmissible infectious illnesses which may trigger ischemic stroke. Despite the association between SARS-CoV-2 and thrombotic events, there are inconsistent data regarding targeted antithrombotics to prevent venous and arterial events. In addition, we provide recommendations for the conduct of stroke research and clinical trial planning during the ongoing COVID-19 pandemic, and for future healthcare crises.

참고문헌 (74)

  1. Nogueira RG, "Global impact of COVID-19 on stroke care and IV thrombolysis", Neurology, 96, pp.e2824~e2838 (2021)
  2. Nogueira RG, "Global impact of COVID-19 on stroke care", Int J Stroke, 16, pp.573~584 (2021)
  3. Nguyen TN, "Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19pandemic", Stroke Vasc Neurol, 6, pp.542~552 (2021)
  4. Siegler JE, "Cerebrovascular events and outcomes in hospitalized patients with COVID-19 : the SVIN COVID-19 Multinational Registry", Int J Stroke, 16, pp.437~447 (2021)
  5. Zhao J, "Impact of the COVID-19 epidemic on stroke care and potential solutions", Stroke, 51, pp.1996~2001 (2020)
  6. Kansagra AP, "Collateral effect of COVID-19 on stroke evaluation in the United States", N Engl J Med, 383, pp.400~401 (2020)
  7. Ortega-Gutierrez S, "Decline in mild stroke presentations and intravenous thrombolysis during the COVID-19 pandemic : the Society of Vascular and Interventional Neurology Multicenter Collaboration", Clin Neurol Neurosurg, 201, pp.106436~ (2021)
  8. Olsen SJ, "Decreased influenza activity during the COVID-19 pandemic: United States, Australia, Chile, and South Africa, 2020", MMWR Morb Mortal Wkly Rep, 69, pp.1305~1309 (2020)
  9. Htun P, "Course of platelet activation and plateletleukocyte interaction in cerebrovascular ischemia", Stroke, 37, pp.2283~2287 (2006)
  10. Lee KR, "Effect of influenza vaccination on risk of stroke : a systematic review and meta-analysis", Neuroepidemiology, 48, pp.103~110 (2017)
  11. Lafond KE, "Global burden of influenza-associated lower respiratory tract infections and hospitalizations among adults : a systematic review and meta-analysis", PLoS Med, 18, pp.e1003550~ (2021)
  12. "Research and data to make progress against the world's largest problems"[URL]
  13. Yavagal DR, "International survey of mechanical thrombectomy stroke systems of care during COVID-19 pandemic", J Stroke Cerebrovasc Dis, 30, pp.105806~ (2021)
  14. Srivastava PK, "Acute ischemic stroke in patients with COVID-19 : an analysis from get with the guidelines-stroke", Stroke, 52, pp.1826~1829 (2021)
  15. Qureshi AI, "Acute ischemic stroke and COVID-19 : an analysis of 27 676 patients", Stroke, 52, pp.905~912 (2021)
  16. de Havenon A, "Impact of COVID-19 on outcomes in ischemic stroke patients in the United States", J Stroke Cerebrovasc Dis, 30, pp.105535~ (2021)
  17. Sasanejad P, "Safety and outcomes of intravenous thrombolytic therapy in ischemic stroke patients with COVID-19 : CASCADE Initiative", J Stroke Cerebrovasc Dis, 30, pp.106121~ (2021)
  18. Leasure AC, "Intracerebral hemorrhage in patients with COVID-19 : an analysis from the COVID-19 Cardiovascular Disease Registry", Stroke, 52, pp.e321~e323 (2021)
  19. Poyiadji N, "COVID-19-associated acute hemorrhagic necrotizing encephalopathy : imaging features", Radiology, 296, pp.E119~E120 (2020)
  20. Connors JM, "COVID-19 and its implications for thrombosis and anticoagulation", Blood, 135, pp.2033~2040 (2020)
  21. Henry BM, "Circulating levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are independent predictors of coronavirus disease 2019 severity: a prospective, observational study", Semin Thromb Hemost, 47, pp.451~455 (2021)
  22. Rohit bhatia, "Stroke in Coronavirus Disease 2019: A Systematic Review", 대한뇌졸중영문학회지, 22(3), pp.324~335 (2020), 대한뇌졸중학회[DOI]
  23. Ramos-Araque ME, "Stroke etiologies in patients with COVID-19 : the SVIN COVID-19 multinational registry", BMC Neurol, 21, pp.43~ (2021)
  24. Strambo D, "Ischemic stroke in COVID-19 patients:Mechanisms, treatment, and outcomes in a consecutive Swiss Stroke Registry analysis", Eur J Neurol, 29, pp.732~743 (2022)
  25. Wolter N, "Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa", bioRxiv, ~ (2021)
  26. Hottz ED, "Platelet activation and plateletmonocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19", Blood, 136, pp.1330~1341 (2020)
  27. Tan M, "Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China", Immunology, 160, pp.261~268 (2020)
  28. Syed F, "Excessive matrix metalloproteinase-1 and hyperactivation of endothelial cells occurred in COVID-19 patients and were associated with the severity of COVID-19", J Infect Dis, 224, pp.60~69 (2021)
  29. Velavan TP, "Mild versus severe COVID-19 : laboratory markers", Int J Infect Dis, 95, pp.304~307 (2020)
  30. Manne BK, "Platelet gene expression and function in patients with COVID-19", Blood, 136, pp.1317~1329 (2020)
  31. Yatim N, "Platelet activation in critically ill COVID-19 patients", Ann Intensive Care, 11, pp.113~ (2021)
  32. Ma A, "Stroke and thromboprophylaxis in the era of COVID-19", J Stroke Cerebrovasc Dis, 30, pp.105392~ (2021)
  33. Bonaventura A, "Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19", Nat Rev Immunol, 21, pp.319~329 (2021)
  34. Lallana S, "Posterior reversible encephalopathy syndrome (PRES) associated with COVID-19", J Clin Neurosci, 88, pp.108~112 (2021)
  35. Smadja DM, "Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients", Angiogenesis, 23, pp.611~620 (2020)
  36. McAlpine LS, "Ischemic stroke, inflammation, and endotheliopathy in COVID-19 patients", Stroke, 52, pp.e233~e238 (2021)
  37. Varga Z, "Endothelial cell infection and endotheliitis in COVID-19", Lancet, 395, pp.1417~1418 (2020)
  38. Keller E, "Large and small cerebral vessel involvement in severe COVID-19 : detailed clinical workup of a case series", Stroke, 51, pp.3719~3722 (2020)
  39. Bilaloglu S, "Thrombosis in hospitalized patients with COVID-19 in a New York City health system", JAMA, 324, pp.799~801 (2020)
  40. Jiménez D, "Incidence of VTE and bleeding among hospitalized patients with coronavirus disease 2019 : a systematic review and meta-analysis", Chest, 159, pp.1182~1196 (2021)
  41. ATTACC Investigators, "Therapeutic anticoagulation with heparin in noncritically ill patients with COVID-19", N Engl J Med, 385, pp.790~802 (2021)
  42. Lopes RD, "Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial", Lancet, 397, pp.2253~2263 (2021)
  43. REMAP-CAP Investigators, "Therapeutic anticoagulation with heparin in critically ill patients with COVID-19", N Engl J Med, 385, pp.777~789 (2021)
  44. INSPIRATION Investigators, "Effect of intermediate-dose vs standard-dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID-19 admitted to the intensive care unit: the INSPIRATION randomized clinical trial", JAMA, 325, pp.1620~1630 (2021)
  45. Chatterjee S, "Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis", JAMA, 311, pp.2414~2421 (2014)
  46. Harris SK, "Gastrointestinal hemorrhage in patients in a respiratory intensive care unit", Chest, 72, pp.301~304 (1977)
  47. Nguyen TN, "Mechanical thrombectomy in the era of the COVID-19 pandemic: emergency preparedness for neuroscience teams. A guidance statement from the Society of Vascular and Interventional Neurology", Stroke, 51, pp.1896~1901 (2020)
  48. Katsanos AH, "Changes in stroke hospital care during the COVID-19 pandemic : a systematic review and meta-analysis", Stroke, 52, pp.3651~3660 (2021)
  49. Siegler JE, "Influence of the COVID-19 pandemic on treatment times for acute ischemic stroke : the Society of Vascular and Interventional Neurology Multicenter Collaboration", Stroke, 52, pp.40~47 (2021)
  50. Plumereau C, "Effect of the COVID-19 pandemic on acute stroke reperfusion therapy : data from the Lyon Stroke Center Network", J Neurol, 268, pp.2314~2319 (2021)
  51. Fuentes B, "Stroke acute management and outcomes during the COVID-19 outbreak : a cohort study from the Madrid Stroke Network", Stroke, 52, pp.552~562 (2021)
  52. Chen Y, "Shortening door-to-needle time by multidisciplinary collaboration and workflow optimization during the COVID-19 pandemic", J Stroke Cerebrovasc Dis, 31, pp.106179~ (2022)
  53. Hall J, "Tenecteplase improves door-to-needle time in real-world acute stroke treatment", Stroke Vasc Interv Neurol, 1, pp.e000102~ (2021)
  54. Warach SJ, "Stroke thrombolysis with tenecteplase to reduce emergency department spread of coronavirus disease 2019 and shortages of alteplase", JAMA Neurol, 77, pp.1203~1204 (2020)
  55. Meinel TR, "Association of initial imaging modality and futile recanalization after thrombectomy", Neurology, 95, pp.e2331~e2342 (2020)
  56. Meinel TR, "Author response : association of initial imaging modality and futile recanalization after thrombectomy", Neurology, 96, pp.916~917 (2021)
  57. Siegler JE, "Reader response : association of initial imaging modality and futile recanalization after thrombectomy", Neurology, 96, pp.915~916 (2021)
  58. Kaesmacher J, "Mechanical thrombectomy in ischemic stroke patients with Alberta Stroke Program Early Computed Tomography Score 0-5", Stroke, 50, pp.880~888 (2019)
  59. Nguyen TN, "Noncontrast computed tomography vs computed tomography perfusion or magnetic resonance imaging selection in late presentation of stroke with largevessel occlusion", JAMA Neurol, 79, pp.22~31 (2022)
  60. Seker F, "Abstract TMP67 : Predictors of unfavourable events despite successful mechanical thrombectomy in the extended window", Stroke, 53(Suppl 1), pp.ATMP67~ (2022)
  61. Nguyen TN, "Response by Nguyen et al to letter regarding article, "Mechanical thrombectomy in the era of the COVID-19 pandemic : emergency preparedness for neuroscience teams : a guidance statement from the society of vascular and interventional neurology"", Stroke, 51, pp.e172~e173 (2020)
  62. Al Kasab S, "International experience of mechanical thrombectomy during the COVID-19 pandemic : insights from STAR and ENRG", J Neurointerv Surg, 12, pp.1039~1044 (2020)
  63. Campbell D, "General anesthesia versus conscious sedation in endovascular thrombectomy for stroke : a meta-analysis of 4 randomized controlled trials", J Neurosurg Anesthesiol, 33, pp.21~27 (2021)
  64. AHA, "ASA Stroke Council Leadership", Temporary emergency guidance to US stroke centers during the coronavirus disease 2019 (COVID-19) pandemic: on behalf of the American Heart Association, Stroke, pp.2020, 51[DOI]
  65. Maringe C, "The impact of the COVID-19 pandemic on cancer deaths due to delays in diagnosis in England, UK: a national, population-based, modelling study", Lancet Oncol, 21, pp.1023~1034 (2020)
  66. Williams R, "Diagnosis of physical and mental health conditions in primary care during the COVID-19 pandemic : a retrospective cohort study", Lancet Public Health, 5, pp.e543~e550 (2020)
  67. Sisó-Almirall A, "Impact of the COVID-19 pandemic on primary health care disease incidence rates : 2017 to 2020", Ann Fam Med, 20, pp.63~68 (2022)
  68. Thau L, "Decline in rehab transfers among rehab-eligible stroke patients during the COVID-19 pandemic", J Stroke Cerebrovasc Dis, 30, pp.105857~ (2021)
  69. Hatcher-Martin JM, "Telemedicine in neurology : Telemedicine Work Group of the American Academy of Neurology update", Neurology, 94, pp.30~38 (2020)
  70. 남효석, "Facilitating Stroke Management using Modern Information Technology", 대한뇌졸중영문학회지, 15(3), pp.135~143 (2013), 대한뇌졸중학회[DOI]
  71. Wilcock AD, "Reperfusion treatment and stroke outcomes in hospitals with telestroke capacity", JAMA Neurol, 78, pp.527~535 (2021)
  72. Guzik AK, "Telestroke across the continuum of care : lessons from the COVID-19 pandemic", J Stroke Cerebrovasc Dis, 30, pp.105802~ (2021)
  73. Moghimi N, "The neurological manifestations of postacute sequelae of SARS-CoV-2 infection", Curr Neurol Neurosci Rep, 21, pp.44~ (2021)
  74. Yassi N, "Use of the estimand framework to manage the disruptive effects of COVID-19 on stroke clinical trials", Stroke, 52, pp.3739~3747 (2021)

관련 논문AI추천

Pathomechanism and Management of Stroke in COVID-19: Review of Immunopathogenesis, Coagulopathy, Endothelial Dysfunction, and Downregulation of ACE2DPG Purwa Samatra, IA Sri Wijayanti, Kumara Tini, Ni Made Susilawathi, Putu Lohita Rahmawati대한신경과학회 · Journal of Clinical Neurology2021 · 제17권 제2호Trends in Stroke Presentations before and during the COVID-19 Pandemic: A Meta-AnalysisAli Zohair Nomani, Ashfaq Shuaib, Asif Javed Butt, Chetan Vekhande, Joseph Kamtchum-Tatuene, Khurshid Khan, Maher Saqqur, Naveed Akhtar, Nida Fatima, Noman Ishaque, Radhika Nair, Sarah Razzaq대한뇌졸중학회 · 대한뇌졸중영문학회지2022 · 제24권 제1호Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and MortalityAndreas Charidimou, Anna Czlonkowska, Anvitha Sathya, Davide Strambo, Diana Aguiar de Sousa, Hannah Lo, Hiroshi Yamagami, James E. Siegler, Jelle Demeestere, João Pedro Marto, Joseph Kwan, Liqun Zhang, Mohamad Abdalkader, Muhammad M. Qureshi, Ossama Yassin Mansour, Patrik Michel, Petra Sedova, Piers Klein, Raul G. Nogueira, Robert Mikulik, Setareh Salehi Omran, Shadi Yaghi, Soma Banerjee, Thalia S. Field, Thanh N. Nguyen, Violiza Inoa대한뇌졸중학회 · 대한뇌졸중영문학회지2022 · 제24권 제2호Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular TreatmentAna Paiva-Nunes, Blanca Fuentes, Davide Strambo, Elena Oana Terecoasa, George Ntaios, João Pedro Marto, João Sargento-Freitas, Jonathan M. Coutinho, Malgorzata Dorobek, Mariana Carvalho-Dias, Marta Nowakowska-Kotas, Martin Kováˇr, Martin Šrámek, Mohamad Abdalkader, Oscar Ayo-Martin, Ossama Yassin Mansour, Pascal Jabbour, Patricia Calleja, Patrik Michel, Pawel Wrona, Priyank Khandelwal, Simona Marcheselli, Simon Escalard, Thanh N Nguyen, Torcato Meira대한뇌졸중학회 · 대한뇌졸중영문학회지2025 · 제27권 제1호Coronavirus Disease 2019 and StrokeJong S. Kim대한뇌졸중학회 · 대한뇌졸중영문학회지2020 · 제22권 제2호Stroke in Coronavirus Disease 2019: A Systematic ReviewDheeraj Khurana, M.V. Padma Srivastava, Radhakrishna Pedapati, Rohit bhatia, Snigdha Komakula, Sreenivas Vishnubhatla대한뇌졸중학회 · 대한뇌졸중영문학회지2020 · 제22권 제3호

이 간행물의 다른 논문 (15건)

Resurrection of Endovascular Thrombectomy for Posterior Circulation StrokeJong S. Kimpp. 177-178Predictors of Therapy Response in Chronic Aphasia: Building a Foundation for Personalized Aphasia TherapyJean Neils-Strunjas, Julius Fridriksson, Sigfus Kristinsson, Dirk B. den Ouden, Chris Rorden, Roger Newman-Norlundpp. 189-206Endovascular Treatment for Posterior Circulation Stroke: Ways to Maximize Therapeutic EfficacyJin Soo Lee, 홍지만, Seong-Joon Lee, Jong S. Kimpp. 207-223Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE)Salim Yusuf, Hans-Christoph Diener, Martin J. O’Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Liu Lisheng, Hongye Zhang, Prem Pais, Patricio Lopez-Jaramillo, Antonio L. Dans, Ahmed Elsayed, Alvaro Avezum, Charles Mondo, Conor Judge, Nana Pogosova, Christian Weimar, Romana Iqbal, Rafael Diaz, Khalid Yusoff, Afzalhussein Yusufali, Ernesto Penaherrera, Okechukwu S. Ogah, Adesola Ogunniyi, Helle K. Iversen, German Malaga, Zvonko Rumboldt, Fawaz Al Hussain, Yongchai Nilanont, Xingyu Wang, Anna Czlonkowska, Graeme J. Hankey, Albertino Damasceno, Shahram Oveisgharan, Peter Langhorne, Aytekin Oguz, Fernando Lanas, Danuta Ryglewicz, Annika Rosengrenpp. 224-235Causal Relations between Exposome and Stroke: A Mendelian Randomization StudyXiang Han, Qiang Dong, Hong-Qi Li, Yi-Wei Feng, Yu-Xiang Yang, Xin-Yi Leng, Prof Can Zhang, Shi-Dong Chen, Kevin Kuo, Shu-Yi Huang, Xue-Qing Zhang, Yi Dong, Xin Cheng, Mei Cui, Lan Tan, Jin-Tai Yupp. 236-244