스테로이드 치료 후 조직학적으로 확인된 C1q Nephropathy 완전관해
Complete Remission from C1q Nephropathy with Disappearance of C1q Deposition after Steroid Therapy
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
.
Abstract
C1q nephropathy is a rare glomerular disease, defined by characteristic mesangial C1q immune deposition seen in immunofluorescence microscopy with no serological evidence of systemic lupus erythematosus. C1q nephropathy can be diagnosed with a subsequent biopsy, as with IgA nephropathy. There are some cases with an initial diagnosis of hematuria and proteinuria with minimal disease changes, focal segmental glomerulonephritis, and mesangial proliferative glomerulonephritis, but lacking C1q nephropathy, in which C1q deposition on immunofluorescence subsequently develops. We report a case that was diagnosed as diffuse mesangial proliferative glomerulonephritis, but a subsequent biopsy showed C1q nephropathy, with C1q deposition in both immunohistochemistry and electron microscopy (EM). We treated the C1q nephropathy with methylprednisolone and confirmed the disappearance of C1q depositions by both immunohistochemistry and EM in a follow-up biopsy.
참고문헌 (10)
- Jennette JC, "C1q nephropathy : a distinct pathologic entity usually causing nephrotic syndrome", Am J Kidney Dis, 6, pp.103~110 (1985)
- Jennette JC, "Immunohistopathologic evaluation of C1q in 800 renal biopsy specimens", Am J Clin Pathol, 83, pp.415~420 (1985)
- Markowitz GS, "C1q nephropathy : a variant of focal segmental glomerulosclerosis", Kidney Int, 64, pp.1232~1240 (2003)
- Lau KK, "C1q nephropathy : features at presentation and outcome", Pediatr Nephrol, 20, pp.744~749 (2005)
- Iskandar SS, "C1q nephropathy : a pediatric clinicopathologic study", Am J Kidney Dis, 18, pp.459~465 (1991)
- Hisano S, "Clinicopathologic correlation and outcome of C1q nephropathy", Clin J Am Soc Nephrol, 3, pp.1637~1643 (2008)
- Srivastava T, "C1q nephropathy presenting as rapidly progressive crescentic glomerulonephritis", Pediatr Nephrol, 14, pp.976~979 (2000)
- Bhowmik DM, "C1q nephropathy presenting as nephritic-neph rotic syndrome", Saudi J Kidney Dis Transpl, 22, pp.561~563 (2011)
- Vizjak A, "Pathology, clinical presentations, and outcomes of C1q nephropathy. See comment in PubMed Commons below", J Am Soc Nephrol, 19, pp.2237~2244 (2008)
- Fukuma Y, "Clinicopathologic correlation of C1q nephropathy in children", Am J Kidney Dis, 47, pp.412~418 (2006)