면역글로불린 치료 후 호전된 전신경화증 위장관 침범 1예
Improved Gastrointestinal Involvement in Systemic Sclerosis after Immunoglobulin Treatment
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초록
전신경화증 환자는 위장관 침범을 하는 경우가 많으나 효과적인 치료법은 부족하다. 저자 등은 식도 내압 검사, 24시간 산도 검사 및 설문조사를 통해 광범위 전신경화증 환자의위장관 침범을 확인하였고 면역글로불린을 투여하여 치료하였다. 이는 국내에서는 드문 증례이므로 문헌고찰과 함께 이를 보고하는 바이다.
Abstract
Systemic sclerosis is an intractable clinical subset characterized by diffuse fibrosis, vasculopathy, and immune abnormalities. Diffuse cutaneous systemic sclerosis has a variety of symptoms depending on the internal organs involved, such as the lungs, heart, kidneys, and gastrointestinal system. Gastrointestinal involvement is frequent and one of the major cause of morbidity and mortality. There is no sustained, effective therapy for treating the active gastrointestinal involvement of systemic sclerosis. Although immunoglobulin is commonly used in the treatment of other autoimmune diseases, its effects in the treatment of the gastrointestinal involvement in systemic sclerosis are unclear. Here, we report a patient with a severe cough caused by uncontrolled gastrointestinal involvement in diffuse cutaneous systemic sclerosis treated with immunoglobulin.
참고문헌 (10)
- Jaovisidha K, "Severe gastrointestinal involvement in systemic sclerosis: report of five cases and review of the literature", Semin Arthritis Rheum, 34, pp.689~702 (2005)
- Ntoumazios SK, "Esophageal involvement in scleroderma:gastroesophageal reflux, the common problem", Semin Arthritis Rheum, 36, pp.173~181 (2006)
- Raja J, "Sustained benefit from intravenous immunoglobulin therapy for gastrointestinal involvement in systemic sclerosis", Rheumatology, 55, pp.115~119 (2016)
- Bellando-Randone S, "Very early diagnosis of systemic sclerosis", Pol Arch Med Wewn, 122(Suppl 1), pp.18~23 (2012)
- Iudici M, "Low-dose pulse cyclophosphamide in interstitial lung disease associated with systemic sclerosis (SSc-ILD): efficacy of maintenance immunosuppression in responders and non-responders", Semin Arthritis Rheum, 44, pp.437~444 (2015)
- Kato R, "A case of advanced systemic sclerosis with severe GERD successfully treated with acotiamide", Surg Case Rep, 2, pp.36~ (2016)
- Mulhearn B, "Indications for IVIG in rheumatic diseases", Rheumatology, 54, pp.383~391 (2015)
- Sholapur NS, "An evaluation of overall effectiveness and treatment satisfaction with intravenous immunoglobulin among patients with immune thrombocytopenia", Transfusion, 56, pp.1739~1744 (2016)
- Clark KE, "Intravenous immunogobulin therapy for severe gastrointestinal involvement in systemic sclerosis", Clin Exp Rheumatol, 33(4 Suppl 91), pp.S168~S170 (2015)
- Poelman CL, "Intravenous immunoglobulin may be an effective therapy for refractory, active diffuse cutaneous systemic sclerosis", J Rheumatol, 42, pp.236~242 (2015)