본문 바로가기
KERD
논문KCI 등재

니볼루맙 치료 도중 발생한 폐포자충 폐렴 1예

Pneumocystis Pneumonia Developing during Treatment of Recurrent Renal Cell Cancer with Nivolumab

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

Nivolumab is an immune checkpoint inhibitor approved for the treatment of metastatic cancers. Here, we report the case of a 65-year-old male with recurrent renal cell carcinoma. After six cycles of nivolumab treatment, positron emission tomography/ computed tomography (PET/CT) was performed to evaluate the response. PET/CT revealed diffuse ground glass opacities in both lungs. He developed a cough, sputum, chills, and a febrile sense. After bronchoscopic bronchoalveolar lavage, pneumocystis pneumonia was finally diagnosed.

Abstract

Nivolumab is an immune checkpoint inhibitor approved for the treatment of metastatic cancers. Here, we report the case of a 65-year-old male with recurrent renal cell carcinoma. After six cycles of nivolumab treatment, positron emission tomography/ computed tomography (PET/CT) was performed to evaluate the response. PET/CT revealed diffuse ground glass opacities in both lungs. He developed a cough, sputum, chills, and a febrile sense. After bronchoscopic bronchoalveolar lavage, pneumocystis pneumonia was finally diagnosed.

참고문헌 (10)

  1. Okazaki T, "A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application", Nat Immunol, 14, pp.1212~1218 (2013)
  2. Nishino M, "Incidence of programmed cell death 1 inhibitor- related pneumonitis in patients with advanced cancer: a systematic review and meta-analysis", JAMA Oncol, 2, pp.1607~1616 (2016)
  3. Naidoo, "Pneumonitis in patients treated with anti-programmed death-1", programmed death ligand 1 therapy, 2017, pp.35, 709~717
  4. Topalian SL, "Safety, activity, and immune correlates of anti-PD-1 antibody in cancer", N Engl J Med, 366, pp.2443~2454 (2012)
  5. Robert C, "Nivolumab in previously untreated melanoma without BRAF mutation", N Engl J Med, 372, pp.320~330 (2015)
  6. Nishino M, "Anti-PD-1-related pneumonitis during cancer immunotherapy", N Engl J Med, 373, pp.288~290 (2015)
  7. Chiou VL, "Pseudoprogression and immune-related response in solid tumors", J Clin Oncol, 33, pp.3541~3543 (2015)
  8. Thomas CF Jr, "Pneumocystis pneumonia", N Engl J Med, 350, pp.2487~2498 (2004)
  9. Rizvi NA, "Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial", Lancet Oncol, 16, pp.257~265 (2015)
  10. Mühlethaler K, "Quantitative PCR to diagnose pneumocystis pneumonia in immunocompromised non-HIV patients", Eur Respir J, 39, pp.971~978 (2012)

관련 논문AI추천

전이성 신세포암에서 Everolimus 사용 후 유발된 간질성 폐렴 1예김도형, 김영민, 김형준, 박건우, 이소라, 이순일, 정지연대한내과학회 · 대한내과학회지2012 · 제83권 제4호Clinical significance of positive Pneumocystis jirovecii polymerase chain reaction in non-human immunodeficiency virus immunocompromised patients in a real practice강지영, 강혜선, 김석찬, 김승준, 김영균, 박연준, 이숙영, 이진국, 이혜연, 이화영대한내과학회 · The Korean Journal of Internal Medicine2017 · 제32권 제3호기관지폐암으로 오인된 면역 정상 환자의폐 효모균증 1예김제훈, 옥철호, 이진영, 장태원, 정만홍대한의진균학회 · 대한의진균학회지2016 · 제21권 제3호신세포암의 폐 전이와 원발성 폐암이 혼동된 1예공성민, 권윤재, 김유석, 김진동, 이유정, 이은서, 지준호대한내과학회 · 대한내과학회지2015 · 제89권 제5호Interstitial Pneumonitis after Treatment with Pemetrexed for Non-small Cell Lung Cancer김경현, 김세현, 박찬우, 송서영, 이승구, 이희영, 임규형, 조준휘, 한선숙대한암학회 · Cancer Research and Treatment2013 · 제45권 제1호Real World Experience of Nivolumab in Non-Small Cell Lung Cancer in Korea강진형, 김동완, 김봉석, 김상위, 김영철, 김주항, 나임일, 박건욱, 안명주, 안호정, 유승수, 이기형, 이성숙, 이승룡, 이종석, 이진수, 임선민, 장태원, 조병철, 조은경대한암학회 · Cancer Research and Treatment2020 · 제52권 제4호

이 간행물의 다른 논문 (7건)