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2023년 개정된 지침서에 근거한 중등도 이상의 궤양성 대장염 치료의 최신 지견

Advancements in the Management of Moderate-to-Severe Ulcerative Colitis: A Revised 2023 Korean Treatment Guidelines

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초록

Biologics such as anti-tumor necrosis factor agents have been the cornerstone for the treatment of inflammatory bowel disease but face limitations, including loss of response and risk of opportunistic infections and malignancies. Newer biologics and small molecules like vedolizumab, ustekinumab, and tofacitinib offer favorable safety profiles and demonstrate efficacy in moderate-to-severe ulcerative colitis. The landscape of the pipeline of biologics and small molecules is rapidly evolving. Upcoming drugs such as upadacitinib, filgotinib, and ozanimod show promise in recently concluded clinical trials, expanding the therapeutic options for ulcerative colitis. This review aims to discuss the medical treatment options available for the management of moderate-to-severe ulcerative colitis, with a focus on biologics and small molecules recommended in revised 2023 Korean guidelines.

Abstract

Biologics such as anti-tumor necrosis factor agents have been the cornerstone for the treatment of inflammatory bowel disease but face limitations, including loss of response and risk of opportunistic infections and malignancies. Newer biologics and small molecules like vedolizumab, ustekinumab, and tofacitinib offer favorable safety profiles and demonstrate efficacy in moderate-to-severe ulcerative colitis. The landscape of the pipeline of biologics and small molecules is rapidly evolving. Upcoming drugs such as upadacitinib, filgotinib, and ozanimod show promise in recently concluded clinical trials, expanding the therapeutic options for ulcerative colitis. This review aims to discuss the medical treatment options available for the management of moderate-to-severe ulcerative colitis, with a focus on biologics and small molecules recommended in revised 2023 Korean guidelines.

참고문헌 (44)

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관련 논문AI추천

Management of inflammatory bowel disease beyond tumor necrosis factor inhibitors: novel biologics and small-molecule drugsSoo-Young Na, You Sun Kim대한내과학회 · The Korean Journal of Internal Medicine2022 · 제37권 제5호Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study예병덕, 차재명, 최창환, Jung Su Young, Kim Hyung Wook, Kim Hyun-Soo, Kim Youngdoe, Lee Hyun Seok, Lim Yun Jeong, Park Jihye, Park Soo Jung, Tae Oh Kim, Yu Jongwook거트앤리버 소화기연관학회협의회 · Gut and Liver2022 · 제16권 제5호Long-term Outcomes of Adalimumab Therapy in Korean Patients with Ulcerative Colitis: A Hospital-Based Cohort StudyByong Duk Ye, Dong-Hoon Yang, Eun Hye Oh, Jeongseok Kim, Jeong-Sik Byeon, Namseok Ham, Sang Hyoung Park, Seung-Jae Myung, Suk-Kyun Yang, Sung Wook Hwang거트앤리버 소화기연관학회협의회 · Gut and Liver2020 · 제14권 제3호Current and Emerging Biologics for Ulcerative Colitis박성철, 진윤태거트앤리버 소화기연관학회협의회 · Gut and Liver2015 · 제9권 제1호궤양성 대장염의 최신치료김주형, 진윤태대한내과학회 · 대한내과학회지2009 · 제76권 제6호Efficacy and Safety of Adalimumab in Moderately to Severely Active Cases of Ulcerative Colitis: A Meta-Analysis of Published Placebo-Controlled TrialsWei Li, Xue Liang Jiang, Zong Mei Zhang거트앤리버 소화기연관학회협의회 · Gut and Liver2016 · 제10권 제2호

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