Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties
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Abstract
There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have long been used to combat inflammation. Recently, cyclooxygenase (COX) inhibitors have been developed and recommended for treatment of rheumatoid arthritis (RA) and osteoarthritis (OA). However, two COX inhibitors have been withdrawn from the market due to unexpected side effects. Because conventional therapeutic and surgical approaches have not been able to fully control the incidence and outcome of many inflammatory diseases, there is an urgent need to find safer compounds and to develop mechanism-based approaches for the management of these diseases. Polyphenols are found in many dietary plant products, including fruits, vegetables, beverages, herbs, and spices. Several of these compounds have been found to inhibit the inflammation process as well as tumorigenesis in experimental animals; they can also exhibit potent biological properties. In addition, epidemiological studies have indicated that populations who consume foods rich in specific polyphenols have lower incidences of inflammatory disease. This paper provides an overview of the research approaches that can be used to unravel the biology and health effects of polyphenols. Polyphenols have diverse biological effects, however, this review will focus on some of the pivotal molecular targets that directly affect the inflammation process.
참고문헌 (82)
- "Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol", 4-acetamidophe(l), pp.410~1
- "the worldwide exploration of nature for novel antitumor agents", pp.156~63 (1997)
- "A class of semi-essential food components their role in human nutrition", the flavo(ids), pp.117~91
- "Flavonol and flavone intakes in US health professionals", pp.1414~20 (2002)
- "Dietary intake and bioavailability of polyphenols", pp.8~ (2000)
- "Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells", pp.2425~32 (2004)
- "Resveratrol enhances the expression of non-steroidal anti-inflammatory drug- activated gene by increasing the expression of p53", pp.425~1 34 (2002)
- "3'-diindolylmethane induce expression of NAG-1 in a p53-independent manner", indole-3-carbi(l and 3), pp.63~9 (2005)
- "is induced by genistein through the expression of p53 in colorectal cancer cells", pp.747~1 53
- "a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic", antipyretic drugs, 2002, 13926~3 31[DOI]
- "Prostaglandin synthase 2", pp.125~40 (1996)
- "Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis", pp.1247~55 (2000), Pincus T
- "Renal effects of COX-2-selective inhibitors", pp.1~15 (2001)
- "Flavonoids and related compounds as inhibition of arachidonic acid peroxidation", pp.627~39
- "Modification of platelet function and arachidonic acid metabolism by bioflavonoids", pp.1525~30
- "The flavonoids of Tanacetum parthenium and T", pp.417~23 (1999)
- "3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos", nu(ura y), pp.1357~60 (1999)
- "Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells", pp.~10 (2003)
- "Mechanism-based in vitro screening of potential cancer chemopreventive agents", pp.523 163~524 72 (2003)
- "inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells", pp.1039~44 (2004)
- "Cancer chemopreventive activity of resveratrol", pp.65~77
- "Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester- treated human mammary epithelial cells", pp.21875~82 (1998)
- "Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives effects on cytosolic phospholipase A", pp.1671~9 (2004)
- "Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure", pp.959~63 (2000)
- "Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin a plant flavone from Scutellaria radix", pp.59~66 (2005)
- "Effects of sophoraflavanone G a prenylated flavonoid from Sophora flavescens on cyclooxygenase-2 and in vivo inflammatory response", pp.329~35 (2002)
- "Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives Relationship to antioxidant activity and to iron ion-reducing ability", pp.1673~81
- "Dual inhibitory activities of tannins from Hamamelis virginiana and related polyphenols on 5-lipoxygenase and lyso-PAF", pp.106~10 (1997)
- "Analytical and pharmacological investigation of Ocotea bullata", pp.219~30 (2000)
- "Selective inhibition of platelet lipoxygenase by baicalein", pp.1090~5
- "Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid", pp.1185~91 (2001)
- "Dual inhibitors of cyclooxygenase and 5-lipoxygenase A new avenue in anti-inflammatory therapy", pp.1433~8 (2001)
- "Selectivity of neutrophil 5-lipoxygenase and cyclo- oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids", pp.787~92
- "Phospholipase A2--a mediator between proximal and distal effectors of inflammation", pp.143~6
- "The expanding superfamily of phospholipase A2 enzymes", pp.1~19 (2000)
- "Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism", mattelia(ml), pp.2765~74
- "Inhibition of neutrophil phospholipase A2 by p-bromophenylacyl bromide", 14-eicosatetray(rdihydroguaiaretic acid ic acid and quercetin), pp.214~7
- "Selective inhibition of group II phospholipase A2 by quercetin", pp.573~82
- "Effects of flavonoids on Naja naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice", pp.~8
- "a novel biflavonoid inhibitor of human secretory phospholipase A2 with anti- inflammatory activity", pp.733~40 (1997)
- "Specific physiological roles of cytosolic phospholipase A2 as defined by gene knockouts", pp.139~48 (2000)
- "orphans with ligands and functions", pp.159~66 (1997)
- "modes of action and human relevance", pp.655~780 (2003)
- "regulators of gene expression in vascular cells", pp.1168~78 (2004)
- "and expression of the human PPARgamma gene" (1997)
- "a distinct PPARgamma mRNA subtype", pp.3 55~60 (1998)
- "Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor", tonto(z p), pp.237~41 (1997)
- "Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas", pp.1281~7 (2002)
- "Peroxisome proliferator-activated receptor gamma ligand troglitazone induces cell cycle arrest and apoptosis of hepatocellular carcinoma cell lines", pp.2243~51 (2002)
- "PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines", pp.82~6 (1998)
- "The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation", pp.79~82 (1998)
- "Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone", pp.1188~93
- "The PPARalpha-leukotriene B4 pathway to inflammation control", pp.39~43 (1996)
- "Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha", pp.51~8 (2004)
- "Effect of green tea polyphenols on the genes with atherosclerotic potential", pp.177~9 (2004), Shukla AR
- "Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF- kappaB activation in A549 cells", pp.105~10 (2002)
- "Screening of edible Japanese plants for nitric oxide generation inhibitory activities in RAW 264", pp.7~ (1998)
- "Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin and quercetin pentaacetate in RAW 264", pp.7 537~48 (2001)
- "In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds", pp.390~7 (1998)
- "Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264", pp.7 941~9 (1999)
- -Gingerol inhibits nitric oxide synthesis in activated J774, , 2003, 3427~37
- "-Epigallocatechin-3-gallate blocks the induction of nitric oxide synthase by down-regulating lipopolysaccharide-induced activity of transcription factor nuclear factor-kappaB", pp.465~72 (1997)
- "Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol", pp.673~80 (1999)
- "Suppression of inducible nitric oxide production by indole and isothiocyanate derivatives from Brassica plants in stimulated macrophages", pp.696~700 (2003)
- "Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation", pp.1445~57 (2000)
- "Cancer chemoprevention with dietary phytochemicals", pp.768~80 (2003)
- "Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens", pp.591~5 (2000)
- "inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells", pp.1680~4 (1997)
- "In vivo quercitrin anti-inflammatory effect involves release of quercetin which inhibits inflammation through down-regulation of the NF-kappaB pathway", pp.584~92 (2005)
- "prevents inflammatory stress in organotypic hippocampal slice cultures", pp.111~20 (2003)
- "an extract of red wine inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF- & kappa", pp.840~1 (2005)
- "Indole-3-carbinol suppresses NF-{kappa}B and I{kappa}B{alpha} kinase activation causing inhibition of expression of NF- {kappa}B-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells", pp.641~9 (2005)
- "Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities", pp.901~8 (2001)
- "Dual function of nonsteroidal anti-inflammatory drugs inhibition of cyclooxygenase and induction of NSAID- activated gene", pp.1126~31 (2002)
- "is a divergent member of the TGF- beta superfamily", pp.11514~1 9 (1997)
- "Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression", pp.20127~35 (2000)
- "Cloning and characterization of a novel member of the transforming growth factor-beta", bone morphogenetic protein family, 1998, 13760~7
- "Characterization of the rat and human genes of growth", differentiation factor-15, pp.1999[DOI]
- "novel placental bone morphogenetic protein", pp.40~4 (1997)
- "Lineage- restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines", pp.310~23 (1999)
- "Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1 which results in the up-regulation of NAG-1", pp.356~64 (2005)
- "is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway", pp.109~14 (2000)
