The Effect of Cryoinjury on Ventricular Tachycardia in the Swine Right Ventricle
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This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation (VF) to ventricular tachycardia (VT) in fibrillating right ventricular (RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines (n=6) and optical mapping were taken from baseline until 10 minutes after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 minutes, was observed in only the cryoinjury site at 5 minutes, and recovered in both sites at 10 minutes. The cycle length of the tachycardia was 135.9±23.6 msec at baseline, 176.2±79.3 msec at 1 minute, 187.6±97.9 msec at 3 minutes, 185.5±19.2 msec at 5 minutes, and 152.1±64.1 msec at 10 minutes. The cycle lengths at 1, 3, and 5 minutes after the cryoinjury were significantly more prolonged than that at baseline (p=0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9 (28.0%), and terminated in 2 (6.3%). These changes were observed mainly within 5 minutes after cryoinjury. The cryoinjury had anti-fibrillatory effects on the tissue with VF. This phenomenon was related to a decreasing mass and stabilizing wavefronts.
Abstract
This study was performed to assess the influence of the cryoinjury on the dynamics of wavefronts and to determine whether they can convert ventricular fibrillation (VF) to ventricular tachycardia (VT) in fibrillating right ventricular (RV) of swines using an optical mapping system. A cryoinjury with a diameter of 12 mm was created on the epicardium of perfused RV of swines (n=6) and optical mapping were taken from baseline until 10 minutes after the cryoinjury. Out of 35 cryoinjuries, the images were possible to be interpreted in 32. The optical action potential could not be observed in either the cryoinjury or peri-injury sites at 1 and 3 minutes, was observed in only the cryoinjury site at 5 minutes, and recovered in both sites at 10 minutes. The cycle length of the tachycardia was 135.9±23.6 msec at baseline, 176.2±79.3 msec at 1 minute, 187.6±97.9 msec at 3 minutes, 185.5±19.2 msec at 5 minutes, and 152.1±64.1 msec at 10 minutes. The cycle lengths at 1, 3, and 5 minutes after the cryoinjury were significantly more prolonged than that at baseline (p=0.001, p=0.006, p=0.016). After the cryoinjury, the VF changed to VT in 9 (28.0%), and terminated in 2 (6.3%). These changes were observed mainly within 5 minutes after cryoinjury. The cryoinjury had anti-fibrillatory effects on the tissue with VF. This phenomenon was related to a decreasing mass and stabilizing wavefronts.
참고문헌 (19)
- "Frequency of sudden cardiac death and profiles of risk", 80, pp.10F~9F (1997)
- "Pathophysiological correlates of ventricular tachycardia in hearts with a healed infarct", pp.415~421 (2000), WB Saunders
- "Sudden cardiac death in the United States 1989 to 1998", pp.2158~63
- "Reentrant excitation around a fixed obstacle in uniform anisotropic ventricular myocardium", pp.1296~306
- "Ventricular reentry around a fixed barrier Resetting with advancement in an in vitro model", pp.267~80
- "Attachment of meandering reentrant wave fronts to anatomic obstacles in the atrium", 81, pp.753~764 (1997)
- "Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit", 93, pp.603~613 (1996)
- "The effects of obstacles on the dynamics of ventricular fibrillation", 35, pp.183~191 (2005)
- "Patterns of wave break during ventricular fibrillation in isolated swine right ventricle", 281, pp.H253~H265 (2001)
- "Effects of diacetyl monoxime and cytochalasin D on ventricular fibrillation in swine right ventricles", 280, pp.H2689~H2696 (2001)
- "On the multiple wavelet hypothesis of atrial fibrillation"
- "Mechanisms of cardiac fibrillation", 270, pp.1222~1125 (1995)
- "Two types of ventricular fibrillation in isolated rabbit hearts: importance of excitability and action potential duration restitution", 106, pp.1859~1866 (2002)
- "A tale of two fibrillations", 108, pp.2298~2303 (2003)
- "Stationary and drifting spiral waves of excitation in isolated cardiac muscle", pp.349~51
- "Spiral waves of excitation underlie reentrant activity in isolated cardiac muscle", pp.631~50
- "Obstacle-induced transition from ventricular fibrillation to tachycardia in isolated swine right ventricles: insights into the transition dynamics and implications for the critical mass", 36, pp.2000~2008 (2000)
- "Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle", 100, pp.1450~1459 (1999)
- "Catheter ablation of ventricular fibrillation in rabbit ventricles treated with beta-blockers", 108, pp.3149~3156 (2003)