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The Prevalence of Human Papillomavirus Infection in Korean Non-Small Cell Lung Cancer Patients

정경영|강신명|신주혜|장준|김성규|신도환|김세규|문진욱|한창훈|김대준|김영삼|박무석|장윤수
연세대학교의과대학 (Yonsei University College of Medicine)|2007.02|Yonsei Medical Journal|제48권 제1호|pp. 69-77

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참고문헌

주제분류의학일반

초록

Abstract

Human papillomavirus (HPV) infection is a co-carcinogen of lung cancer and contributes to its pathogenesis. To evaluate the prevalence of HPV infection, polymerase chain reaction (PCR) was employed to detect HPV 16, 18, and 33 DNA in tumor tissues of 112 patients with non-small cell lung cancer (NSCLC) who underwent curative surgery from Jan. 1995 to Dec. 1998 at Severance Hospital, Seoul, Korea. The patients consisted of 90 men and 22 women. Nineteen patients were under 50 years old (17%), and 92 patients (82%) were smokers. Fifty-three patients had adenocarcinomas, while 59 patients had non-adenocarcinomas. Early stage (I and II) cancer was found in 64 patients (57.1%) and advanced stage (III and IV) found in 48 (42.9%). The prevalence of HPV 16, 18, and 33 were 12 (10.7%), 11 (9.8%), and 37 (33.0%), respectively. Smoking status, sex, and histologic type were not statistically different in the presence of HPV DNA. The presence of HPV 16 was more common in younger patients and HPV 18 was more common in advanced stage patients. This study showed that the prevalence rate of HPV 16 and 18 infections in NSCLC tissue was low, suggesting HPV 16 and 18 infections played a limited role in lung carcinogenesis of Koreans. However, the higher prevalence of HPV 33 infections in Korean lung cancer patients compared to other Asian and Western countries may be important and warrants further investigation.

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관련 논문AI추천

Genotype Frequency of Human Papillomavirus Determined by PCR and DNA Sequencing in Korean Women김경태, 성혜순, 이경옥, 이혜정, 정나영, 정수진대한임상검사과학회 · 대한임상검사과학회지2006 · 제38권 제2호자궁경부 종양에서 인유두종 바이러스 아형에 관한 연구김판영, 배동한, 서정호, 이동운, 정동준, 선우재근대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제10호HPV Genotyping in Squamous Cell Carcinoma of Upper Aerodigestive Tract김영, 김성순, 남종희, 민병우, 박창수, 정운재, 정은희, 최유덕대한병리학회 · Journal of Pathology and Translational Medicine2010 · 제44권 제5호Lung Cancer in KoreaHoon-Kyo Kim대한암학회 · Cancer Research and Treatment2002 · 제34권 제1호Epidemiology of Lung Cancer in Korea이춘택대한암학회 · Cancer Research and Treatment2002 · 제34권 제1호Detection of Human Papillomavirus in Korean Breast Cancer Patients by Real-Time Polymerase Chain Reaction and Meta-Analysis of Human Papillomavirus and Breast Cancer김애리, 김정율, 김하연, 이진환, 이혜승, 장혜윤, 최유진, Jinhyuk Choi대한병리학회 · Journal of Pathology and Translational Medicine2016 · 제50권 제6호

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