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Activation of Intrarenal Complement System in Mouse Model for Chronic Cyclosporine Nephrotoxicity

임선우|안경옥|김수현|김진영|양현주|김진|최범순|양철우|Can Li|강희정|김영옥|기정연
연세대학교의과대학 (Yonsei University College of Medicine)|2007.06|Yonsei Medical Journal|제48권 제3호|pp. 517-525

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참고문헌

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초록

Abstract

Purpose: Local activation of the complement system plays a role in target organ damage. The aim of our study was to investigate the influence of cyclosporine (CsA)- induced renal injury on the complement system in the kidney. Materials and Methods: Mice fed a low salt (0.01%) diet were treated with vehicle (VH, olive oil, 1mL/kg/day) or CsA (30mg/ kg/day) for one or four weeks. Induction of chronic CsA nephrotoxicity was evaluated with renal function and histomorphology. Activation of the complement system was assessed through analysis of the expression of C3, C4d, and membrane attack complex (MAC), and the regulatory proteins, CD46 and CD55. CsA treatment induced renal dysfunction and typical morphology (tubulointerstitial inflammation and fibrosis) at four weeks. Results: CsA-induced renal injury was associated with increased the expression of C3, C4d, and MAC (C9 and upregulation of complement regulatory proteins (CD 46 and CD55). Immunohistochemistry revealed that the activated complement components were mainly confined to the injured tubulointerstitium. Conclusion: CsA-induced renal injury is associated with activation of the intrarenal complement system.

참고문헌 (35)

  1. Walport MJ, "Complement. First of two parts", 344, pp.1058~1066 (2001)
  2. Walport MJ, "Complement. Second of two parts", 344, pp.1140~1144 (2001)
  3. Nangaku M, "Cellular response to injury in membranous nephropathy", 16, pp.1195~1204 (2005)
  4. Vakeva AP, "Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy", 97, pp.2259~2267 (1998)
  5. Yamada K, "Critical protection from renal ischemia reperfusion injury by CD55 and CD59", 172, pp.3869~3875 (2004)
  6. Sogabe H, "Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis", 167, pp.2791~2797 (2001)
  7. Sacks SH, "Endogenous complement C3 synthesis in immune complex nephritis", pp.1273~4
  8. Hsu SI, "Chronic progression of tubulointerstitial damage in proteinuric renal disease is mediated by complement activation: a therapeutic role for complement inhibitors?", 14, pp.S186~S191 (2003)
  9. Nangaku M, "C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys", 13, pp.928~936 (2002)
  10. Nangaku M, "CD59 protects glomerular endothelial cells from immune-mediated thrombotic microangiopathy in rats", 9, pp.590~597 (1998)
  11. Qin X, "Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes", 53, pp.2653~2661 (2004)
  12. Pratt JR, "Local synthesis of complement component C3 regulates acute renal transplant rejection", 8, pp.582~587 (2002)
  13. Li C, "Chronic cyclosporine nephrotoxicity: new insights and preventive strategies", 45, pp.1004~1016 (2004)
  14. Olyaei AJ, "Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies", 7, pp.384~389 (2001)
  15. Yang CW, "Expression of apoptosis- related genes in chronic cyclosporine nephrotoxicity in mice", 2, pp.391~399 (2002)
  16. Mazzali M, "Effects of cyclosporine in osteopontin null mice", 62, pp.78~85 (2002)
  17. Turnberg D, "CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice", 14, pp.2271~2279 (2003)
  18. Tang S, "Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells", 10, pp.69~76 (1999)
  19. Welch TR, "Differential expression of complement C3 and C4 in the human kidney", pp.1451~8
  20. Collins AB, "Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries", 10, pp.2208~2214 (1999)
  21. Mroz A, "C4d complement split product in diagnosis of immunological activity of chronic allograft nephropathy", 38, pp.97~100 (2006)
  22. Straatsburg IH, "Complement activation induced by ischemia-reperfusion in humans: a study in patients undergoing partial hepatectomy", 32, pp.783~791 (2000)
  23. Chang T, "Smokeless tobacco extracts activate complement in vitro: a potential pathogenic mechanism for initiating inflammation of the oral mucosa", 87, pp.223~229 (1998)
  24. Nangaku M, "Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome", 10, pp.2323~2331 (1999)
  25. Rangan GK, "C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria", 67, pp.492~503 (2005)
  26. "Immunohistochemical demonstration of membrane cofactor protein of complement in normal and diseased kidney tissues", iku(t)
  27. Cosio FG, "Localization of decay accelerating factor in normal and diseased kidneys", pp.100~7
  28. Tamai H, "Localization of 20-kD homologous restriction factor", pp.256~62
  29. Lim SW, "Cyclosporine-induced renal injury induces toll-like receptor and maturation of dendritic cells", 80, pp.691~699 (2005)
  30. Li C, "Pravastatin treatment attenuates interstitial inflammation and fibrosis in a rat model of chronic cyclosporine-induced nephropathy", 286, pp.F46~F57 (2004)
  31. Shagdarsuren E, "Complement activation in angiotensin II-induced organ damage", 97, pp.716~724 (2005)
  32. Pasch MC, "Synthesis of complement components C3 and factor B in human keratinocytes is differentially regulated by cytokines", 114, pp.78~82 (2000)
  33. Lee EK, "Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS", 17, pp.325~333 (2005)
  34. Xin J, "Suppression of cyclosporine a nephrotoxicity in vivo by transforming growth factor beta receptor-immunoglobulin G chimeric protein", 77, pp.1433~1442 (2004)
  35. Lee CT, "Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild-type mice", 62, pp.2055~2061 (2002)

관련 논문AI추천

Chronic Cyclosporine Nephrotoxicity: New Insights and Preventive Strategices선보경, 양철우, 임선우, Can Li연세대학교의과대학 · Yonsei Medical Journal2004 · 제45권 제6호Exploring complement activation as a therapeutic target in lupus nephritisLim Beom Jin대한소아신장학회 · Childhood Kidney Diseases2025 · 제29권 제3호Impact of Cyclosporin on Podocyte ZO-1 Expression in Puromycin Aminonucleoside Nephrosis Rats강신욱, 김범석, 박형천, 이호영, 최규헌, 하성규, 한대석연세대학교의과대학 · Yonsei Medical Journal2005 · 제46권 제1호Induction of PPAR Gamma mRNA and Protein Expression by Rosiglitazone in Chronic Cyclosporine Nephropathy in the Rat김진, 김용수, 안경옥, 양철우, 양현주, 임선우, 최범순, Akira Sugawara, Can Li, Sadayoshi Ito연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제2호The Expression of C4d and HLA-DR in Renal Allografts with the Histologic Features of Antibody-Mediated Rejection박문향, 송영수대한병리학회 · Journal of Pathology and Translational Medicine2008 · 제42권 제5호Expanding therapeutic horizons of calcineurin inhibitors in lupus nephritis: from tacrolimus to next-generation agentsYoon-Kyoung Sung대한내과학회 · The Korean Journal of Internal Medicine2025 · 제40권 제6호

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