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Macrophage Apoptosis in Tuberculosis

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초록

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects alveolar macrophages following aerosol transmission. Lung macrophages provide a critical intracellular niche that is required for Mtb to establish infection in the human host. This parasitic relationship is made possible by the capacity of Mtb to block phagosome maturation following entry into the host macrophage, creating an environment that supports bacillary replication. Apoptosis is increasingly understood to play a role in host defense against intracellular pathogens including viruses, fungi, protozoa and bacteria. In the last 15 years an understanding of the role that macrophage apoptosis plays in TB has begun to emerge. Here we review the history and current state of the art of this topic and we offer a model of the macrophage-pathogen interaction that takes into the account the complexities of programmed cell death and the relationship between various death signaling pathways and host defense in TB.

Abstract

Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that infects alveolar macrophages following aerosol transmission. Lung macrophages provide a critical intracellular niche that is required for Mtb to establish infection in the human host. This parasitic relationship is made possible by the capacity of Mtb to block phagosome maturation following entry into the host macrophage, creating an environment that supports bacillary replication. Apoptosis is increasingly understood to play a role in host defense against intracellular pathogens including viruses, fungi, protozoa and bacteria. In the last 15 years an understanding of the role that macrophage apoptosis plays in TB has begun to emerge. Here we review the history and current state of the art of this topic and we offer a model of the macrophage-pathogen interaction that takes into the account the complexities of programmed cell death and the relationship between various death signaling pathways and host defense in TB.

참고문헌 (70)

  1. Schlesinger LS, "Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors", J Immunol, 150, pp.2920~2930 (1993)
  2. Zimmerli S, "Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages", Am J Respir Cell Mol Biol, 15, pp.760~770 (1996)
  3. Rohde K, "Mycobacterium tuberculosis and the environment within the phagosome", Immunol Rev, 219, pp.37~54 (2007)
  4. Flynn JL, "Immunology of tuberculosis", Annu Rev Immunol, 19, pp.93~129 (2001)
  5. Leemans JC, "Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice", J Immunol, 166, pp.4604~4611 (2001)
  6. Knapp S, "Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia", Am J Respir Crit Care Med, 167, pp.171~179 (2003)
  7. Canetti G, "Present aspects of bacterial resistance in tuberculosis", Am Rev Respir Dis, 92, pp.687~703 (1965)
  8. Roulston A, "Viruses and apoptosis", Annu Rev Microbiol, 53, pp.577~628 (1999)
  9. McCormick AL, "Control of apoptosis by human cytomegalovirus", Curr Top Microbiol Immunol, 325, pp.281~295 (2008)
  10. Clouston WM, "Apoptosis, lymphocytotoxicity and the containment of viral infections", Med Hypotheses, 18, pp.399~404 (1985)
  11. Ray CA, "Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin- 1 beta converting enzyme", Cell, 69, pp.597~604 (1992)
  12. Clem RJ, "Prevention of apoptosis by a baculovirus gene during infection of insect cells", Science, 254, pp.1388~1390 (1991)
  13. Zychlinsky A, "Programmed cell death in infectious diseases", Trends Microbiol, 1, pp.114~117 (1993)
  14. Huynh ML, "Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation", J Clin Invest, 109, pp.41~50 (2002)
  15. Chung EY, "Regulation of cytokine production during phagocytosis of apoptotic cells", Cell Res, 6, pp.154~161 (2006)
  16. Schaible UE, "Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis", Nat Med, 9, pp.1039~1046 (2003)
  17. Creagh EM, "Caspase-activation pathways in apoptosis and immunity", Immunol Rev, 193, pp.10~21 (2003)
  18. Chen M, "Initiator caspases in apoptosis signaling pathways", Apoptosis, 7, pp.313~319 (2002)
  19. Taylor RC, "Apoptosis: controlled demolition at the cellular level", Nat Rev Mol Cell Biol, 9, pp.231~241 (2008)
  20. Riedl SJ, "The apoptosome: signalling platform of cell death", Nat Rev Mol Cell Biol, 8, pp.405~413 (2007)
  21. Youle RJ, "The BCL-2 protein family: opposing activities that mediate cell death", Nat Rev Mol Cell Biol, 9, pp.47~59 (2008)
  22. Lockshin RA, "Caspase-independent cell deaths", Curr Opin Cell Biol, 14, pp.727~733 (2002)
  23. Kroemer G, "Caspase-independent cell death", Nat Med, 11, pp.725~730 (2005)
  24. Bröker LE, "Cell death independent of caspases: a review", Clin Cancer Res, 11, pp.3155~3162 (2005)
  25. Guicciardi ME, "Lysosomes in cell death", Oncogene, 23, pp.2881~2890 (2004)
  26. Chwieralski CE, "Cathepsin-regulated apoptosis", Apoptosis, 11, pp.143~149 (2006)
  27. Cookson BT, "Pro-inflammatory programmed cell death", Trends Microbiol, 9, pp.113~114 (2001)
  28. Henry T, "Activation of the inflammasome upon Francisella tularensis infection: interplay of innate immune pathways and virulence factors", Cell Microbiol, 9, pp.2543~2551 (2007)
  29. Cervantes J, "Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages", Cell Microbiol, 10, pp.41~52 (2008)
  30. Suzuki T, "Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages", PLoS Pathog, 3, pp.e111~ (2007)
  31. Boya P, "Lysosomal membrane permeabilization in cell death", Oncogene, 27, pp.6434~6451 (2008)
  32. Keane J, "Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis", Infect Immun, 65, pp.298~304 (1997)
  33. Keane J, "Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages", J Immunol, 164, pp.2016~2020 (2000)
  34. Spira A, "Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: A pivotal role for tumor necrosis factor", Am J Respir Cell Mol Biol, 29, pp.545~551 (2003)
  35. Balcewicz-Sablinska MK, "Pathogenic Mycobacterium tuberculosis evades apoptosis of host macrophages by release of TNF-R2, resulting in inactivation of TNF-alpha", J Immunol, 161, pp.2636~2641 (1998)
  36. Sly LM, "Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1", J Immunol, 170, pp.430~437 (2003)
  37. Molloy A, "Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin", J Exp Med, 180, pp.1499~1509 (1994)
  38. Riendeau CJ, "THP-1 cell apoptosis in response to Mycobacterial infection", Infect Immun, 71, pp.254~259 (2003)
  39. Oddo M, "Fas ligand-induced apoptosis of infected human macrophages reduces the viability of intracellular Mycobacterium tuberculosis", J Immunol, 160, pp.5448~5454 (1998)
  40. Velmurugan K, "Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells", PLoS Pathog, 3, pp.e110~ (2007)
  41. Fratazzi C, "Programmed cell death of Mycobacterium avium serovar 4- infected human macrophages prevents mycobacteria from spreading and induces mycobacterial growth inhibition by freshly added, uninfected macrophages", J Immunol, 158, pp.4320~4327 (1997)
  42. Lee J, "Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway", J Immunol, 176, pp.4267~4274 (2006)
  43. Hinchey J, "Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis", J Clin Invest, 117, pp.2279~2288 (2007)
  44. Park JS, "Virulent clinical isolates of Mycobacterium tuberculosis grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages", J Leukoc Biol, 79, pp.80~86 (2006)
  45. Kroemer G, "Classification of cell death: recommendations of the Nomenclature Committee on Cell Death", Cell Death Differ, 12(2), pp.1463~1467 (2005)
  46. Teitelbaum R, "Mycobacterial infection of macrophages results in membrane-permeable phagosomes", Proc Natl Acad Sci U S A, 96, pp.15190~15195 (1999)
  47. van der Wel N, "M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells", Cell, 129, pp.1287~1298 (2007)
  48. Bursch W, "The autophagosomal-lysosomal compartment in programmed cell death", Cell Death Differ, 8, pp.569~581 (2001)
  49. Rojas M, "Differential induction of apoptosis by virulent Mycobacterium tuberculosis in resistant and susceptible murine macrophages: role of nitric oxide and mycobacterial products", J Immunol, 159, pp.1352~1361 (1997)
  50. Rojas M, "Induction of apoptosis in murine macrophages by Mycobacterium tuberculosis is reactive oxygen intermediates-independent", Biochem Biophys Res Commun, 247, pp.436~442 (1998)
  51. Rojas M, "TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages", J Immunol, 162, pp.6122~6131 (1999)
  52. Ciaramella A, "Induction of apoptosis and release of interleukin-1 beta by cell wall-associated 19-kDa lipoprotein during the course of mycobacterial infection", J Infect Dis, 190, pp.1167~1176 (2004)
  53. López M, "The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2", J Immunol, 170, pp.2409~2416 (2003)
  54. Smith RA, "The P2X7 purinergic receptor on bovine macrophages mediates mycobacterial death", Vet Immunol Immunopathol, 78, pp.249~262 (2001)
  55. Fairbairn IP, "ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion", J Immunol, 167, pp.3300~3307 (2001)
  56. Biswas D, "ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes", macrophages, 2008, pp.9, 35~
  57. Pan H, "Ipr1 gene mediates innate immunity to tuberculosis", Nature, 434, pp.767~772 (2005)
  58. Gan H, "Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence", Nat Immunol, 9, pp.1189~1197 (2008)
  59. Yamasaki S, "Mincle is an ITAM-coupled activating receptor that senses damaged cells", Nat Immunol, 9, pp.1179~1188 (2008)
  60. Turner OC, "Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis", Infect Immun, 71, pp.864~871 (2003)
  61. Gil O, "Intragranulomatous necrosis in lungs of mice infected by aerosol with Mycobacterium tuberculosis is related to bacterial load rather than to any one cytokine or T cell type", Microbes Infect, 8, pp.628~636 (2006)
  62. Pandey AK, "Mycobacterial persistence requires the utilization of host cholesterol", Proc Natl Acad Sci U S A, 통권 : 105, pp.4376~4380 (2008)
  63. Wong H, "Accumulation of cholesteryl ester and lipid droplets in macrophages after uptake of cholesterol-rich necrotic products", Arteriosclerosis, 7, pp.185~190 (1987)
  64. Placido R, "Apoptosis of human monocytes", macrophages in Mycobacterium tuberculosis infection, 1997, pp.181, 31~38
  65. Sánchez MD, "Functional and phenotypic changes in monocytes from patients with tuberculosis are reversed with treatment", Microbes Infect, 8, pp.2492~2500 (2006)
  66. Murphy FJ, "Therapeutic approaches to the modulation of apoptosis", Essays Biochem, 39, pp.131~153 (2003)
  67. Reed JC, "Apoptosis mechanisms: implications for cancer drug discovery", Oncology, 18(13), pp.11~20 (2004)
  68. Keane J, "Tuberculosis associated with infliximab, a tumor necrosis factor alphaneutralizing agent", N Engl J Med, 345, pp.1098~1104 (2001)
  69. Condos R, "Treatment of multidrug-resistant pulmonary tuberculosis with interferon-gamma via aerosol", Lancet, 349, pp.1513~1515 (1997)
  70. Grode L, "Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin", J Clin Invest, 115, pp.2472~2479 (2005)

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