Clinicopathologic Features and Outcomes of Metaplastic Breast Carcinoma: Comparison with Invasive Ductal Carcinoma of the Breast
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Purpose: Metaplastic breast carcinoma (MBC) is rare. Its clinicopathologic features and prognosis are uncertain. The aim of this study was to evaluate the clinicopathologic characteristics and outcomes in comparison with invasive ductal carcinoma (IDC). Materials and Methods: We reviewed the data of 29 patients with MBC and 4,851 patients with IDC, who received surgery at Yonsei University Severance Hospital between 1980 and 2008. Various clinicopathologic features, recurrence free, and overall survival were investigated and compared to each other. Results:Stage IV cases at diagnosis were more common in MBC (10.3%) than in IDC (0.9%). The incidence rates of triple negative breast cancer (TNBC) were significantly higher in MBC (84.0%) than in IDC (20.1%). Larger tumors (>2 cm)and lower tendency of axillary metastasis were frequently observed in MBC. Only one of 24 preoperative core needle biopsies (CNB) correctly diagnosed MBC. There was no significant difference in survival between the two groups. Conclusion: MBC was characterized by a higher incidence of TNBC, larger tumor size, and lower tendency of axillary metastasis, and was difficult to diagnose with CNB. Although the incidence of stage IV disease at diagnosis was higher in MBC, the survival rates of stage I-III were comparable to those of IDC.
Abstract
Purpose: Metaplastic breast carcinoma (MBC) is rare. Its clinicopathologic features and prognosis are uncertain. The aim of this study was to evaluate the clinicopathologic characteristics and outcomes in comparison with invasive ductal carcinoma (IDC). Materials and Methods: We reviewed the data of 29 patients with MBC and 4,851 patients with IDC, who received surgery at Yonsei University Severance Hospital between 1980 and 2008. Various clinicopathologic features, recurrence free, and overall survival were investigated and compared to each other. Results:Stage IV cases at diagnosis were more common in MBC (10.3%) than in IDC (0.9%). The incidence rates of triple negative breast cancer (TNBC) were significantly higher in MBC (84.0%) than in IDC (20.1%). Larger tumors (>2 cm)and lower tendency of axillary metastasis were frequently observed in MBC. Only one of 24 preoperative core needle biopsies (CNB) correctly diagnosed MBC. There was no significant difference in survival between the two groups. Conclusion: MBC was characterized by a higher incidence of TNBC, larger tumor size, and lower tendency of axillary metastasis, and was difficult to diagnose with CNB. Although the incidence of stage IV disease at diagnosis was higher in MBC, the survival rates of stage I-III were comparable to those of IDC.
참고문헌 (35)
- Oberman HA, "Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients", Am J Surg Pathol, 11, pp.918~929 (1987)
- Wargotz ES, "Metaplastic carcinomas of the breast. II. Spindle cell carcinoma", Hum Pathol, 20, pp.732~740 (1989)
- Wargotz ES, "Metaplastic carcinomas of the breast. III. Carcinosarcoma", Cancer, 64, pp.1490~1499 (1989)
- Wargotz ES, "Metaplastic carcinomas of the breast. I. Matrix-producing carcinoma", Hum Pathol, 20, pp.628~635 (1989)
- Wargotz ES, "Metaplastic carcinomas of the breast: V. Metaplastic carcinoma with osteoclastic giant cells", Hum Pathol, 21, pp.1142~1150 (1990)
- Wargotz ES, "Metaplastic carcinomas of the breast. IV. Squamous cell carcinoma of ductal origin", Cancer, 65, pp.272~276 (1990)
- Beatty JD, "Metaplastic breast cancer: clinical significance", Am J Surg, 191, pp.657~664 (2006)
- Chao TC, "Metaplastic carcinomas of the breast", J Surg Oncol, 71, pp.220~225 (1999)
- Gutman H, "Biologic distinctions and therapeutic implications of sarcomatoid metaplasia of epithelial carcinoma of the breast", J Am Coll Surg, 180, pp.193~199 (1995)
- Bellino R, "Metaplastic breast carcinoma: pathology and clinical outcome", Anticancer Res, 23, pp.669~673 (2003)
- Khan HN, "Spindle cell carcinoma of the breast: a case series of a rare histological subtype", Eur J Surg Oncol, 29, pp.600~603 (2003)
- Reis-Filho JS, "Metaplastic breast carcinomas are basal-like tumours", Histopathology, 49, pp.10~21 (2006)
- Rakha EA, "Triple-negative", basal-like breast cancer:review, 2009, pp.41, 40~47
- Korsching E, "Basal carcinoma of the breast revisited: an old entity with new interpretations", J Clin Pathol, 61, pp.553~560 (2008)
- Irvin WJ Jr, "What is triple-negative breast cancer?", Eur J Cancer, 44, pp.2799~2805 (2008)
- Barnes PJ, "Metaplastic breast carcinoma: clinical-pathologic characteristics and HER2", neu expression, 2005, pp.91, 173~178
- Tavassoli FA, "Classification of metaplastic carcinomas of the breast", Pathol Annu, 27, pp.89~119 (1992)
- Park JH, "The clinicopathologic characteristics of 38 metaplastic carcinomas of the breast", J Breast Cancer, 8, pp.59~63 (2005)
- Pezzi CM, "Characteristics and treatment of metaplastic breast cancer:analysis of 892 cases from the National Cancer Data Base", Ann Surg Oncol, 14, pp.166~173 (2007)
- Son BH, "Survival Analysis of Korean Breast Cancer Patients Diagnosed between 1993 and 2002 in Korea - A Nationwide Study of the Cancer Registry", J Breast Cancer, 9, pp.214~229 (2006)
- 이은숙, "The Clinical Characteristics and Predictive Factors of Stage IV Breast Cancer at the Initial Presentation: A Review of a Single Institute’s Data", Journal of Breast Cancer, 10(2), pp.101~106 (2007), 한국유방암학회
- Gilbert JA, "Molecular analysis of metaplastic breast carcinoma:high EGFR copy number via aneusomy", Mol Cancer Ther, 7, pp.944~951 (2008)
- Rayson D, "Metaplastic breast cancer: prognosis and response to systemic therapy", Ann Oncol, 10, pp.413~419 (1999)
- Geyer FC, "Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas", J Pathol, 220, pp.562~573 (2010)
- Leibl S, "Metaplastic breast carcinomas are negative for Her-2 but frequently express EGFR (Her-1): potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors?", J Clin Pathol, 58, pp.700~704 (2005)
- Kim MJ, "Clinicopathologic significance of the basal-like subtype of breast cancer: a comparison with hormone receptor and Her2", neuoverexpressing phenotypes, 2006, pp.37, 1217~1226
- Chhieng C, "Metaplastic carcinoma of the breast with osteocartilaginous heterologous elements", Am J Surg Pathol, 22, pp.188~194 (1998)
- Perou CM, "Molecular portraits of human breast tumours", Nature, 406, pp.747~752 (2000)
- Sørlie T, "Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications", Proc Natl Acad Sci U S A, 98, pp.10869~10874 (2001)
- Luini A, "Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature", Breast Cancer Res Treat, 101, pp.349~353 (2007)
- Kuroda N, "Basal-like carcinoma of the breast: further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas", Med Mol Morphol, 41, pp.117~120 (2008)
- Garcia S, "Poor prognosis in breast carcinomas correlates with increased expression of targetable CD146 and c-Met and with proteomic basal-like phenotype", Hum Pathol, 38, pp.830~841 (2007)
- Weigelt B, "Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis", Breast Cancer Res Treat, 117, pp.273~280 (2009)
- Park JM, "Metaplastic carcinoma of the breast: mammographic and sonographic findings", J Clin Ultrasound, 28, pp.179~186 (2000)
- Lien HC, "Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition", Oncogene, 26, pp.7859~7871 (2007)