Lipid Emulsions Enhance the Norepinephrine-Mediated Reversal of Local Anesthetic-Induced Vasodilation at Toxic Doses
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Intravenous lipid emulsions have been used to treat the systemic toxicity of local anesthetics. The goal of this in vitro study was to examine the effects of lipid emulsions on the norepinephrine-mediated reversal of vasodilation induced by high doses of levobupivacaine, ropivacaine, and mepivacaine in isolated endothelium-denuded rat aorta, and to determine whether such effects are associated with the lipid solubility of local anesthetics. Materials and Methods: The effects of lipid emulsions (0.30, 0.49, 1.40, and 2.61%) on norepinephrine concentration-responses in high-dose local anesthetic (6×10-4 M levobupivacaine, 2×10-3 M ropivacaine, and 7×10-3 M mepivacaine)-induced vasodilation of isolated aorta precontracted with 60 mM KCl were assessed. The effects of lipid emulsions on local anesthetic- and diltiazem-induced vasodilation in isolated aorta precontracted with phenylephrine were also assessed. Results: Lipid emulsions (0.30%) enhanced norepinephrine-induced contraction in levobupivacaine-induced vasodilation, whereas 1.40 and 2.61% lipid emulsions enhanced norepinephrine-induced contraction in both ropivacaine- and mepivacaine-induced vasodilation, respectively. Lipid emulsions (0.20, 0.49 and 1.40%) inhibited vasodilation induced by levobupivacaine and ropivacaine, whereas 1.40 and 2.61% lipid emulsions slightly attenuated mepivacaine (3×10-3 M)-induced vasodilation. In addition,lipid emulsions attenuated diltiazem-induced vasodilation. Lipid emulsions enhanced norepinephrine-induced contraction in endothelium-denuded aorta without pretreatment with local anesthetics. Conclusion: Taken together, these results suggest that lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic anesthetic doses and inhibit local anesthetic-induced vasodilation in a manner correlated with the lipid solubility of a particular local anesthetic.
Abstract
Purpose: Intravenous lipid emulsions have been used to treat the systemic toxicity of local anesthetics. The goal of this in vitro study was to examine the effects of lipid emulsions on the norepinephrine-mediated reversal of vasodilation induced by high doses of levobupivacaine, ropivacaine, and mepivacaine in isolated endothelium-denuded rat aorta, and to determine whether such effects are associated with the lipid solubility of local anesthetics. Materials and Methods: The effects of lipid emulsions (0.30, 0.49, 1.40, and 2.61%) on norepinephrine concentration-responses in high-dose local anesthetic (6×10-4 M levobupivacaine, 2×10-3 M ropivacaine, and 7×10-3 M mepivacaine)-induced vasodilation of isolated aorta precontracted with 60 mM KCl were assessed. The effects of lipid emulsions on local anesthetic- and diltiazem-induced vasodilation in isolated aorta precontracted with phenylephrine were also assessed. Results: Lipid emulsions (0.30%) enhanced norepinephrine-induced contraction in levobupivacaine-induced vasodilation, whereas 1.40 and 2.61% lipid emulsions enhanced norepinephrine-induced contraction in both ropivacaine- and mepivacaine-induced vasodilation, respectively. Lipid emulsions (0.20, 0.49 and 1.40%) inhibited vasodilation induced by levobupivacaine and ropivacaine, whereas 1.40 and 2.61% lipid emulsions slightly attenuated mepivacaine (3×10-3 M)-induced vasodilation. In addition,lipid emulsions attenuated diltiazem-induced vasodilation. Lipid emulsions enhanced norepinephrine-induced contraction in endothelium-denuded aorta without pretreatment with local anesthetics. Conclusion: Taken together, these results suggest that lipid emulsions enhance the norepinephrine-mediated reversal of local anesthetic-induced vasodilation at toxic anesthetic doses and inhibit local anesthetic-induced vasodilation in a manner correlated with the lipid solubility of a particular local anesthetic.
참고문헌 (32)
- Charbonneau H, "Early use of lipid emulsion to treat incipient mepivacaine intoxication", Reg Anesth Pain Med, 34, pp.277~278 (2009)
- Schaeffer E, "Local anaesthetics intoxication, during ultrasound-guided axillary plexus block, treated by Intralipide", Ann Fr Anesth Reanim, 29, pp.929~930 (2010)
- Sakai T, "Ropivacaine-induced late-onset systemic toxicity after transversus abdominis plane block under general anesthesia: successful reversal with 20% lipid emulsion", Masui, 59, pp.1502~1505 (2010)
- Dix SK, "Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion", Crit Care Med, 39, pp.872~874 (2011)
- Weinberg G, "Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity", Reg Anesth Pain Med, 28, pp.198~202 (2003)
- Foxall G, "Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid", Anaesthesia, 62, pp.516~518 (2007)
- Ok SH, "Lipid emulsion reverses Levobupivacaine-induced responses in isolated rat aortic vessels", Anesthesiology, 114, pp.293~301 (2011)
- Baik JS, "Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent", Can J Physiol Pharmacol, 89, pp.467~476 (2011)
- Sung HJ, "Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta", Can J Physiol Pharmacol, 90, pp.863~872 (2012)
- Li B, "Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats", Br J Anaesth, 108, pp.857~863 (2012)
- Harvey M, "Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: transient circulatory return in rabbits", Anesth Analg, 111, pp.791~796 (2010)
- Liu L, "The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart", Anesth Analg, 114, pp.886~893 (2012)
- Hiller DB, "Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect", Anesthesiology, 111, pp.498~505 (2009)
- Hollenberg SM, "Vasoactive drugs in circulatory shock", Am J Respir Crit Care Med, 183, pp.847~855 (2011)
- Heavner JE, "Resuscitation from bupivacaine-induced asystole in rats: comparison of different cardioactive drugs", Anesth Analg, 80, pp.1134~1139 (1995)
- 옥성호, "Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration", Korean Journal of Anesthesiology, 63(3), pp.253~259 (2012), 대한마취통증의학회
- Sung HJ, "Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility", J Biomed Biotechnol, 2012, pp.170958~ (2012)
- Cassidy SL, "Lipid solubility of a series of drugs and its relevance to fatal poisoning", J Pharm Pharmacol, 40, pp.130~132 (1988)
- Cox B, "Toxicity of local anaesthetics", Best Pract Res Clin Anaesthesiol, 17, pp.111~136 (2003)
- Zapata-Sudo G, "Is comparative cardiotoxicity of S(-) and R(+) bupivacaine related to enantiomer-selective inhibition of L-type Ca(2+) channels?", Anesth Analg, 92, pp.496~501 (2001)
- Sung HJ, "Direct effect of ropivacaine involves lipoxygenase pathway activation in rat aortic smooth muscle", Can J Anaesth, 56, pp.298~306 (2009)
- Strichartz GR, "Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs", Anesth Analg, 71, pp.158~170 (1990)
- Ozcan MS, "Update on the use of lipid emulsions in local anesthetic systemic toxicity: a focus on differential efficacy and lipid emulsion as part of advanced cardiac life support", Int Anesthesiol Clin, 49, pp.91~103 (2011)
- Huang JM, "Long-chain fatty acids activate calcium channels in ventricular myocytes", Proc Natl Acad Sci U S A, 89, pp.6452~6456 (1992)
- Weinberg GL, "Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose", Anesthesiology, 117, pp.180~187 (2012)
- Waring WS, "Intravenous lipid administration for drug-induced toxicity: a critical review of the existing data", Expert Rev Clin Pharmacol, 5, pp.437~444 (2012)
- Montiel V, "Diltiazem poisoning treated with hyperinsulinemic euglycemia therapy and intravenous lipid emulsion", Eur J Emerg Med, 18, pp.121~123 (2011)
- Groban L, "Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model", Reg Anesth Pain Med, 28, pp.3~11 (2003)
- Santos AC, "Systemic toxicity of ropivacaine during ovine pregnancy", Anesthesiology, 75, pp.137~141 (1991)
- Tanoubi I, "Systemic toxicity with mepivacaine following axillary block in a patient with terminal kidney failure", Ann Fr Anesth Reanim, 25, pp.33~35 (2006)
- Mertes N, "Safety and efficacy of a new parenteral lipid emulsion (SMOFlipid) in surgical patients: a randomized, double-blind, multicenter study", Ann Nutr Metab, 50, pp.253~259 (2006)
- Weinberg GL, "Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart", Reg Anesth Pain Med, 31, pp.296~303 (2006)
