Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis
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Purpose: The association between autoimmune thyroid diseases (AITDs) and vitaminD deficiency is controversial. We aimed to evaluate the relationship between serum25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. Materials and Methods: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absenceof anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. Results: The patients with elevatedanti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factorsthat may affect the presence of TPOAb in the AITDs group. Conclusion: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
Abstract
Purpose: The association between autoimmune thyroid diseases (AITDs) and vitaminD deficiency is controversial. We aimed to evaluate the relationship between serum25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. Materials and Methods: 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absenceof anti-thyroid antibodies. The relationship between anti-thyroid peroxidase antibody (TPOAb) and 25(OH)D3 was evaluated. Results: The patients with elevatedanti-thyroid antibodies had lower levels of serum 25(OH)D3 than those who did not (12.6±5.5 ng/mL vs. 14.5±7.3 ng/mL, respectively, p<0.001). Importantly, after adjusting for age, sex, and body mass index, a negative correlation (r=-0.252, p<0.001) was recognized between 25(OH)D3 and TPOAb levels in the AITDs group, but this correlation did not exist in the non-AITDs group (r=0.117, p=0.127). 25(OH)D3 level was confirmed as an independent factor after adjusting for co-factorsthat may affect the presence of TPOAb in the AITDs group. Conclusion: 25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.
참고문헌 (29)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- Wang TJ, "Vitamin D deficiency and risk of cardiovascular disease", Circulation, 117, pp.503~511 (2008)
- Zittermann A, "Putting cardiovascular disease and vitamin D insufficiency into perspective", Br J Nutr, 94, pp.483~492 (2005)
- Kamen DL, "Vitamin D deficiency in systemic lupus erythematosus", Autoimmun Rev, 5, pp.114~117 (2006)
- Huisman AM, "Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia", J Rheumatol, 28, pp.2535~2539 (2001)
- Shapira Y, "Mycobacterium tuberculosis, autoimmunity, and vitamin D", Clin Rev Allergy Immunol, 38, pp.169~177 (2010)
- Hyppönen E, "Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study", Lancet, 358, pp.1500~1503 (2001)
- Kivity S, "Vitamin D and autoimmune thyroid diseases", Cell Mol Immunol, 8, pp.243~247 (2011)
- Proal AD, "Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women", Ann N Y Acad Sci, 1173, pp.252~259 (2009)
- Goswami R, "Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey", Br J Nutr, 102, pp.382~386 (2009)
- Lips P, "The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation", J Intern Med, 260, pp.245~254 (2006)
- Holick MF, "High prevalence of vitamin D inadequacy and implications for health", Mayo Clin Proc, 81, pp.353~373 (2006)
- Greene-Finestone LS, "25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates", Osteoporos Int, 22, pp.1389~1399 (2011)
- Gordon CM, "Prevalence of vitamin D deficiency among healthy infants and toddlers", Arch Pediatr Adolesc Med, 162, pp.505~512 (2008)
- Choi HS, "Vitamin D insufficiency in Korea--a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008", J Clin Endocrinol Metab, 96, pp.643~651 (2011)
- McGrogan A, "The incidence of autoimmune thyroid disease: a systematic review of the literature", Clin Endocrinol (Oxf), 69, pp.687~696 (2008)
- Canaris GJ, "The Colorado thyroid disease prevalence study", Arch Intern Med, 160, pp.526~534 (2000)
- Volpe R, "The pathophysiology of autoimmune thyroid disease", Endocr Regul, 25, pp.187~192 (1991)
- Prummel MF, "Interferon-alpha and autoimmune thyroid disease", Thyroid, 13, pp.547~551 (2003)
- Arnson Y, "Vitamin D and autoimmunity: new aetiological and therapeutic considerations", Ann Rheum Dis, 66, pp.1137~1142 (2007)
- van Etten E, "Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts", J Steroid Biochem Mol Biol, 97, pp.93~101 (2005)
- Cantorna MT, "Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease", Prog Biophys Mol Biol, 92, pp.60~64 (2006)
- Tamer G, "Relative vitamin D insufficiency in Hashimoto’s thyroiditis", Thyroid, 21, pp.891~896 (2011)
- Haussler MR, "The nuclear vitamin D receptor: biological and molecular regulatory properties revealed", J Bone Miner Res, 13, pp.325~349 (1998)
- van Halteren AG, "1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis", J Autoimmun, 23, pp.233~239 (2004)
- Boonstra A, "1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells", J Immunol, 167, pp.4974~4980 (2001)
- van Halteren AG, "Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3)", Diabetes, 51, pp.2119~2125 (2002)
- Mahon BD, "The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells", J Cell Biochem, 89, pp.922~932 (2003)
- Waterhouse JC, "Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease", Ann N Y Acad Sci, 1173, pp.757~765 (2009)