High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma
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We report a case of regression of multiple pulmonary metastases, which originated from hepatocellular carcinoma after treatmentwith intravenous administration of high-dose vitamin C. A 74-year-old woman presented to the clinic for her cancer-related symptoms such as general weakness and anorexia. After undergoing initial transarterial chemoembolization (TACE), local recurrencewith multiple pulmonary metastases was found. She refused further conventional therapy, including sorafenib tosylate (Nexavar). She did receive high doses of vitamin C (70 g), which were administered into a peripheral vein twice a week for 10 months, and multiple pulmonary metastases were observed to have completely regressed. She then underwent subsequent TACE, resulting in remission of her primary hepatocellular carcinoma.
Abstract
We report a case of regression of multiple pulmonary metastases, which originated from hepatocellular carcinoma after treatmentwith intravenous administration of high-dose vitamin C. A 74-year-old woman presented to the clinic for her cancer-related symptoms such as general weakness and anorexia. After undergoing initial transarterial chemoembolization (TACE), local recurrencewith multiple pulmonary metastases was found. She refused further conventional therapy, including sorafenib tosylate (Nexavar). She did receive high doses of vitamin C (70 g), which were administered into a peripheral vein twice a week for 10 months, and multiple pulmonary metastases were observed to have completely regressed. She then underwent subsequent TACE, resulting in remission of her primary hepatocellular carcinoma.
참고문헌 (22)
- Padayatty SJ, "Vitamin C as an antioxidant: evaluation of its role in disease prevention", J Am Coll Nutr, 22, pp.18~35 (2003)
- Levine M, "New concepts in the biology and biochemistry of ascorbic acid", N Engl J Med, 314, pp.892~902 (1986)
- Bei R, "Impaired expression and function of cancer-related enzymes by anthocyans: an update", Curr Enzym Inhib, 8, pp.2~21 (2012)
- Bram S, "Vitamin C preferential toxicity for malignant melanoma cells", Nature, 284, pp.629~631 (1980)
- Grosso G, "Effects of vitamin C on health: a review of evidence", Front Biosci (Landmark Ed), 18, pp.1017~1029 (2013)
- Padayatty SJ, "Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects", PLoS One, 5, pp.e11414~ (2010)
- Campbell A, "Reticulum cell sarcoma: two complete ‘spontaneous’ regressions, in response to high-dose ascorbic acid therapy. A report on subsequent progress", Oncology, 48, pp.495~497 (1991)
- Padayatty SJ, "Intravenously administered vitamin C as cancer therapy: three cases", CMAJ, 174, pp.937~942 (2006)
- Riordan HD, "Intravenous ascorbic acid: protocol for its application and use", P R Health Sci J, 22, pp.287~290 (2003)
- Cameron E, "The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer", Chem Biol Interact, 9, pp.285~315 (1974)
- Cameron E, "Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer", Proc Natl Acad Sci U S A, 75, pp.4538~4542 (1978)
- Cameron E, "Innovation vs. quality control: an ‘unpublishable’clinical trial of supplemental ascorbate in incurable cancer", Med Hypotheses, 36, pp.185~189 (1991)
- Moertel CG, "High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison", N Engl J Med, 312, pp.137~141 (1985)
- Padayatty SJ, "Vitamin C pharmacokinetics: implications for oral and intravenous use", Ann Intern Med, 140, pp.533~537 (2004)
- Hoffer LJ, "Phase I clinical trial of i.v. ascorbic acid in advanced malignancy", Ann Oncol, 19, pp.1969~1974 (2008)
- González MJ, "Orthomolecular oncology review: ascorbic acid and cancer 25 years later", Integr Cancer Ther, 4, pp.32~44 (2005)
- Chen Q, "Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo", Proc Natl Acad Sci U S A, 104, pp.8749~8754 (2007)
- Gonzalez MJ, "Lipid peroxidation and tumor growth: an inverse relationship", Med Hypotheses, 38, pp.106~110 (1992)
- Sun Y, "Lowered antioxidant enzymes in spontaneously transformed embryonic mouse liver cells in culture", Carcinogenesis, 14, pp.1457~1463 (1993)
- Cho D, "Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells", Melanoma Res, 13, pp.549~554 (2003)
- Chen C, "Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L: -ascorbate on pancreatic tumors in athymic mice", Pathol Oncol Res, 15, pp.109~114 (2009)
- Mikirova N, "Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients", J Transl Med, 11, pp.191~ (2013)
