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Capillary Electrophoresis에 의한 Carvedilol 및 그 대사체의 거울상이성질체 분리

Separation of racemin enantiomer carvedilol and its metabolites using capillary electrophoresis

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Abstract

A capillary electrophoresis method for the separation of carvedilol and its metabolites enantiomersconcentration and capillary temperature for enantiomer resolution were investigated. Best results were obtainedby 15 mM carboxymethyl-β-cyclodextrin in the run bufer. Also the effect of capillary temperature on efficiencywas assessed. The optimized method was applied for separation of chiral carvedilol and its three metabolites.

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