Associations for BCO2, PCSK9, and TR1B1 Polymorphism and Lifestyle Factors with Ischemic Stroke: A Nested Case-Control Study
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Purpose: To investigate associations for polymorphisms in β-carotene 9',10'-oxygenase (BCO2, rs10431036 and rs11214109), proproteinconvertase subtilisin kexin type 9 (PCSK9, rs11583680), and tribbles pseudokinase 1 (TRIB1, rs17321515 and rs2954029), aswell as lifestyle factors, with ischemic stroke (IS). Materials and Methods: This nested case-control study included 161 patients with IS and 483 matched control individuals. Wecollected medical reports, lifestyle details, and blood samples from individuals and used the PCR-ligase detection reaction methodto genotype single nucleotide polymorphisms (SNPs). Results: The GA+AA genotype of rs10431036 (p<0.001) and rs17321515 (p=0.003), the CT+TT genotype of rs11214109 (p=0.005),and the TA+AA genotype of rs2954029 (p=0.006) in dominant models increased the risk of IS. In additive models, the GG genotypeof rs17321515 (p=0.005) and the TT genotype of rs2954029 (p=0.008) increased the risk of IS. Adequate intake of fruits/vegetablesreduced the risk of IS (p=0.005). Although there was no interaction between genes and fruits/vegetables, people with inadequateintake of fruits/vegetables who carried a risk genotype had a higher risk of IS than those only having inadequate fruits/vegetables intake or those only carrying a risk genotype. Also, the haplotypes AC, AT, and GT (comprising rs10431036 andrs11214109) and GT (comprising rs2954029 and rs17321515) were found to be associated with an increased risk of IS (p<0.05). Conclusion: Polymorphisms in BCO2 and TRIB1 and fruits/vegetables intake were associated with IS. These results provide thetheoretical basis for gene screening to prevent chronic cerebrovascular diseases.
Abstract
Purpose: To investigate associations for polymorphisms in β-carotene 9',10'-oxygenase (BCO2, rs10431036 and rs11214109), proproteinconvertase subtilisin kexin type 9 (PCSK9, rs11583680), and tribbles pseudokinase 1 (TRIB1, rs17321515 and rs2954029), aswell as lifestyle factors, with ischemic stroke (IS). Materials and Methods: This nested case-control study included 161 patients with IS and 483 matched control individuals. Wecollected medical reports, lifestyle details, and blood samples from individuals and used the PCR-ligase detection reaction methodto genotype single nucleotide polymorphisms (SNPs). Results: The GA+AA genotype of rs10431036 (p<0.001) and rs17321515 (p=0.003), the CT+TT genotype of rs11214109 (p=0.005),and the TA+AA genotype of rs2954029 (p=0.006) in dominant models increased the risk of IS. In additive models, the GG genotypeof rs17321515 (p=0.005) and the TT genotype of rs2954029 (p=0.008) increased the risk of IS. Adequate intake of fruits/vegetablesreduced the risk of IS (p=0.005). Although there was no interaction between genes and fruits/vegetables, people with inadequateintake of fruits/vegetables who carried a risk genotype had a higher risk of IS than those only having inadequate fruits/vegetables intake or those only carrying a risk genotype. Also, the haplotypes AC, AT, and GT (comprising rs10431036 andrs11214109) and GT (comprising rs2954029 and rs17321515) were found to be associated with an increased risk of IS (p<0.05). Conclusion: Polymorphisms in BCO2 and TRIB1 and fruits/vegetables intake were associated with IS. These results provide thetheoretical basis for gene screening to prevent chronic cerebrovascular diseases.
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