1Determination of potical purity of N-acetyl-1 -naphthylethylamine by chiral chromatography and NMR spectroscopy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
(R)-N-3,5-dinitrobenzoyl (DNB) phenylglycinol derived chiral selector was used as a HPLC chiral stationary phase (CSP) for the resolution of racemic N-acylnaphthylalkylamines. In this study, determination of optical purity was performed by both chiral chromatography and NMR spectroscopy by using the (R)-phenylglycinol derived chiral selector. The data of accuracy and precision of each optical purity value are calculated from the results of NMR and HPLC experiments by comparing with true value. Average error of the NMR method was +2.2% with average RSD of 4.54%, while that of HPLC method was -3.5% with average RSD of 3.23%.
Abstract
(R)-N-3,5-dinitrobenzoyl (DNB) phenylglycinol derived chiral selector was used as a HPLC chiral stationary phase (CSP) for the resolution of racemic N-acylnaphthylalkylamines. In this study, determination of optical purity was performed by both chiral chromatography and NMR spectroscopy by using the (R)-phenylglycinol derived chiral selector. The data of accuracy and precision of each optical purity value are calculated from the results of NMR and HPLC experiments by comparing with true value. Average error of the NMR method was +2.2% with average RSD of 4.54%, while that of HPLC method was -3.5% with average RSD of 3.23%.
참고문헌 (10)
- , Angew. Chem. Int. Ed., 41, pp.1998~2007 (2002)
- Noyori, , Angew. Chem. Int. Ed., 41, pp.2008~2023 (2002)
- Sharpless, , Angew. Chem. Int. Ed., 41, pp.2024~2032 (2002)
- M. L. Lorin, , J. Chromatogr. A, 1206, pp.123~130 (2008)
- W. Dougherty, , Tetrahedron Letters, 31, pp.4389~4390 (1990)
- J. Shen, , J. Chromatogr. A, 1059, pp.209~214 (2004)
- O. M. Demchuk, , Tetrahedron: Asymmetry, 19, pp.2339~2345 (2008)
- M. Sawada, , Inter. J. Mass Spectrometry, 193, pp.123~130 (1999)
- J. J. Ryoo, , Microchemical J., 63, pp.128~133 (1999)
- K. H. Kim, , J. Pharm. & Biomed. Anal., 25, pp.947~956 (2001)