Feasibility and Applicability of Wireless Handheld Ultrasound Measurement of Carotid Intima-Media Thickness in Patients with Cardiac Symptoms
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Purpose: Routine screening for carotid intima-media thickness (CIMT) and cardiovascular (CV) disease in asymptomatic patientshas been criticized for the high costs and large number of patients required for detecting one patient with coronary artery disease(CAD). In order to overcome the low cost-effectiveness thereof, we investigated the feasibility of an economic wireless handheldultrasound (WHUS) device for CIMT measurement in symptomatic patients. Materials and Methods: A total of 100 consecutive patients with cardiac symptoms were enrolled. CIMT was measured in all patients. Coronary angiography was performed in 75 patients indicated for the exam. Results: The mean of maximal CIMT measured from left/right common carotid artery and bulb (max-CIMT) by the WHUS deviceshowed excellent agreement [intraclass correlation coefficient (ICC)=0.960] with a standard ultrasound device and great interobserverrepeatability (ICC>0.9 between all observers). Receiver operating characteristic curve analysis showed that the predictivepower for CAD was improved when max-CIMT and plaque information (plaque≥2) was added [area under the curve (AUC):0.838] to the traditional clinical CV risk factors (AUC: 0.769). The cutoff values for CAD prediction with the standard device and theWHUS device were 1.05 mm (AUC: 0.807, sensitivity: 0.78, specificity: 0.53) and 1.10 mm (AUC: 0.725, sensitivity: 0.98, specificity:0.27), respectively. Conclusion: max-CIMT measured by a WHUS device showed excellent agreement and repeatability, compared with standard ultrasound. Combined max-CIMT and plaque information added predictive power to the traditional clinical CV risk factors in detectinghigh-risk CAD patients.
Abstract
Purpose: Routine screening for carotid intima-media thickness (CIMT) and cardiovascular (CV) disease in asymptomatic patientshas been criticized for the high costs and large number of patients required for detecting one patient with coronary artery disease(CAD). In order to overcome the low cost-effectiveness thereof, we investigated the feasibility of an economic wireless handheldultrasound (WHUS) device for CIMT measurement in symptomatic patients. Materials and Methods: A total of 100 consecutive patients with cardiac symptoms were enrolled. CIMT was measured in all patients. Coronary angiography was performed in 75 patients indicated for the exam. Results: The mean of maximal CIMT measured from left/right common carotid artery and bulb (max-CIMT) by the WHUS deviceshowed excellent agreement [intraclass correlation coefficient (ICC)=0.960] with a standard ultrasound device and great interobserverrepeatability (ICC>0.9 between all observers). Receiver operating characteristic curve analysis showed that the predictivepower for CAD was improved when max-CIMT and plaque information (plaque≥2) was added [area under the curve (AUC):0.838] to the traditional clinical CV risk factors (AUC: 0.769). The cutoff values for CAD prediction with the standard device and theWHUS device were 1.05 mm (AUC: 0.807, sensitivity: 0.78, specificity: 0.53) and 1.10 mm (AUC: 0.725, sensitivity: 0.98, specificity:0.27), respectively. Conclusion: max-CIMT measured by a WHUS device showed excellent agreement and repeatability, compared with standard ultrasound. Combined max-CIMT and plaque information added predictive power to the traditional clinical CV risk factors in detectinghigh-risk CAD patients.
참고문헌 (20)
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