An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy
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Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala andmedial temporal structures, with or without hippocampal sclerosis. LATE-NC is typically observed in individuals aged 80 years orolder and manifests clinically as amnestic memory decline. Herein, we report a case of LATE diagnosed by brain autopsy in an82-year-old male who had an 11-year history of memory impairment. Pathological examination revealed high Alzheimer diseaseneuropathological changes, as well as amygdala-predominant Lewy body pathology. In addition, immunohistochemistry forTDP-43 revealed neuronal and glial cytoplasmic inclusions in the dentate gyrus of the hippocampus, amygdala, and inferior temporalcortex. Increasing awareness of the newly defined entity LATE will enhance our understanding of the neurodegenerativeprocesses that occur in the oldest individuals.
Abstract
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala andmedial temporal structures, with or without hippocampal sclerosis. LATE-NC is typically observed in individuals aged 80 years orolder and manifests clinically as amnestic memory decline. Herein, we report a case of LATE diagnosed by brain autopsy in an82-year-old male who had an 11-year history of memory impairment. Pathological examination revealed high Alzheimer diseaseneuropathological changes, as well as amygdala-predominant Lewy body pathology. In addition, immunohistochemistry forTDP-43 revealed neuronal and glial cytoplasmic inclusions in the dentate gyrus of the hippocampus, amygdala, and inferior temporalcortex. Increasing awareness of the newly defined entity LATE will enhance our understanding of the neurodegenerativeprocesses that occur in the oldest individuals.
참고문헌 (12)
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