본문 바로가기
KERD
논문KCI 등재

Exercise Across the Phases of Cancer Survivorship: A Narrative Review

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류의학일반

초록

Exercise has long been recognized as an important component of treatment for various diseases. However, the benefits and risks of exercise interventions must be carefully evaluated to ensure the former outweighs the latter. As cancer patients undergo diverse treatment modalities with distinct objectives, a systematic approach partitioning the cancer journey into distinct phases is necessary to inform tailored exercise prescriptions. This narrative review summarizes exercise benefits and mechanisms for cancer patients and survivors across four distinct survivorship periods—before surgery, after surgery and before adjuvant treatment, during nonsurgical treatment (adjuvant and neoadjuvant), and during extended survival. In summary, exercise reduces the risks of complications and declines in physical functioning while improving fatigue, quality of life, and the ability to manage treatment effects. Although additional research is warranted, existing evidence is sufficient to integrate exercise into clinical oncology practice and cancer survivorship programs.

Abstract

Exercise has long been recognized as an important component of treatment for various diseases. However, the benefits and risks of exercise interventions must be carefully evaluated to ensure the former outweighs the latter. As cancer patients undergo diverse treatment modalities with distinct objectives, a systematic approach partitioning the cancer journey into distinct phases is necessary to inform tailored exercise prescriptions. This narrative review summarizes exercise benefits and mechanisms for cancer patients and survivors across four distinct survivorship periods—before surgery, after surgery and before adjuvant treatment, during nonsurgical treatment (adjuvant and neoadjuvant), and during extended survival. In summary, exercise reduces the risks of complications and declines in physical functioning while improving fatigue, quality of life, and the ability to manage treatment effects. Although additional research is warranted, existing evidence is sufficient to integrate exercise into clinical oncology practice and cancer survivorship programs.

참고문헌 (83)

  1. Tipton CM, "The history of"exercise is medicine"in ancient civilizations", Adv Physiol Educ, 38, pp.109~117 (2014)
  2. Taylor RS, "The role of cardiac rehabilitation in improving cardiovascular outcomes", Nat Rev Cardiol, 19, pp.180~194 (2022)
  3. Courneya KS, "Framework PEACE : an organizational model for examining physical exercise across the cancer experience", Ann Behav Med, 23, pp.263~272 (2001)
  4. Mullan F, "Seasons of survival : reflections of a physician with cancer", N Engl J Med, 313, pp.270~273 (1985)
  5. Miller K, "Seasons of survivorship revisited", Cancer J, 14, pp.369~374 (2008)
  6. Bilimoria KY, "Wait times for cancer surgery in the United States : trends and predictors of delays", Ann Surg, 253, pp.779~785 (2011)
  7. Ho PJ, "Impact of delayed treatment in women diagnosed with breast cancer : a population-based study", Cancer Med, 9, pp.2435~2444 (2020)
  8. Rapoport Y, "Psychosocial problems in head-and-neck cancer patients and their change with time since diagnosis", Ann Oncol, 4, pp.69~73 (1993)
  9. Xiao J, "Association of low muscle mass and low muscle radiodensity with morbidity and mortality for colon cancer surgery", JAMA Surg, 155, pp.942~949 (2020)
  10. Weerink LBM, "Low skeletal muscle mass and postoperative morbidity in surgical oncology : a systematic review and meta-analysis", J Cachexia Sarcopenia Muscle, 11, pp.636~649 (2020)
  11. Wang X, "Prognostic value of depression and anxiety on breast cancer recurrence and mortality : a systematic review and meta-analysis of 282, 203 patients", Mol Psychiatry, 25, pp.3186~3197 (2020)
  12. Silver JK, "Cancer prehabilitation : an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes", Am J Phys Med Rehabil, 92, pp.715~727 (2013)
  13. Bagaria SP, "Delay to colectomy and survival for patients diagnosed with colon cancer", J Invest Surg, 32, pp.350~357 (2019)
  14. Steffens D, "Is preoperative physical activity level of patients undergoing cancer surgery associated with postoperative outcomes? A systematic review and meta-analysis", Eur J Surg Oncol, 45, pp.510~518 (2019)
  15. Roman M, "Meta-analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes", Br J Surg, 106, pp.181~189 (2019)
  16. Dhanis J, "Prehabilitation to improve outcomes of patients with gynaecological cancer : a new window of opportunity?", Cancers(Basel), 14, pp.3448~ (2022)
  17. Molenaar CJL, "Effect of multimodal prehabilitation on reducing postoperative complications and enhancing functional capacity following colorectal cancer surgery : the PREHAB randomized clinical trial", JAMA Surg, 158, pp.572~581 (2023)
  18. Ikeda T, "Effectiveness of early exercise on reducing skeletal muscle loss during preoperative neoadjuvant chemotherapy for esophageal cancer", Surg Today, 52, pp.1143~1152 (2022)
  19. Avancini A, "Exercise prehabilitation in lung cancer : getting stronger to recover faster", Eur J Surg Oncol, 47, pp.1847~1855 (2021)
  20. Møller T, "At cancer diagnosis : a ‘window of opportunity’ for behavioural change towards physical activity. A randomised feasibility study in patients with colon and breast cancer", BMJ Open, 3, pp.e003556~ (2013)
  21. Ligibel JA, "Exercise, diet, and weight management during cancer treatment : ASCO guideline", J Clin Oncol, 40, pp.2491~2507 (2022)
  22. Price P, "Treatment of cancer" (2020), CRC Press
  23. Lovelace DL, "Long-term effects of breast cancer surgery, treatment, and survivor care", J Midwifery Womens Health, 64, pp.713~724 (2019)
  24. Panda N, "Expected versus experienced health-related quality of life among patients recovering from cancer surgery : a prospective cohort study", Ann Surg Open, 2, pp.e060~ (2021)
  25. Huang CY, "Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced-stage ovarian cancer", J Cachexia Sarcopenia Muscle, 11, pp.534~546 (2020)
  26. Nakashima Y, "Skeletal muscle loss after esophagectomy is an independent risk factor for patients with esophageal cancer", Ann Surg Oncol, 27, pp.492~498 (2020)
  27. Riba LA, "Surgical risk factors for the delayed initiation of adjuvant chemotherapy in breast cancer", Ann Surg Oncol, 25, pp.1904~1911 (2018)
  28. Xia BT, "Time to initiation of adjuvant chemotherapy in pancreas cancer : a multi-institutional experience", Ann Surg Oncol, 24, pp.2770~2776 (2017)
  29. Petrelli F, "Timing of adjuvant chemotherapy and survival in colorectal, gastric, and pancreatic cancer. A systematic review and meta-analysis", Cancers(Basel), 11, pp.550~ (2019)
  30. Sung LH, "Enhanced recovery after surgery of patients undergoing radical cystectomy for bladder cancer", Transl Androl Urol, 9, pp.2986~2996 (2020)
  31. Willner A, "Effects of early postoperative mobilization following gastrointestinal surgery : systematic review and meta-analysis", BJS Open, 7, pp.zrad102~ (2023)
  32. Ahn KY, "The effects of inpatient exercise therapy on the length of hospital stay in stages I-III colon cancer patients : randomized controlled trial", Int J Colorectal Dis, 28, pp.643~651 (2013)
  33. Min J, "Postoperative inpatient exercise facilitates recovery after laparoscopic surgery in colorectal cancer patients : a randomized controlled trial", BMC Gastroenterol, 23, pp.127~ (2023)
  34. Wang K, "Prevalence of pain in patients with breast cancer post-treatment : a systematic review", Breast, 42, pp.113~127 (2018)
  35. Bruce J, "Exercise versus usual care after non-reconstructive breast cancer surgery(UK PROSPER) : multicentre randomised controlled trial and economic evaluation", BMJ, 375, pp.e066542~ (2021)
  36. Machado P, "Effect of exercise training on quality of life after colorectal and lung cancer surgery : a meta-analysis", Cancers(Basel), 13, pp.4975~ (2021)
  37. Carayol M, "Psychological effect of exercise in women with breast cancer receiving adjuvant therapy : what is the optimal dose needed?", Ann Oncol, 24, pp.291~300 (2013)
  38. van Vulpen JK, "Effects of physical exercise during adjuvant breast cancer treatment on physical and psychosocial dimensions of cancer-related fatigue : a meta-analysis", Maturitas, 85, pp.104~111 (2016)
  39. Furmaniak AC, "Exercise for women receiving adjuvant therapy for breast cancer", Cochrane Database Syst Rev, 9, pp.CD005001~ (2016)
  40. Lipsett A, "The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life : a systematic review and meta-analysis", Breast, 32, pp.144~155 (2017)
  41. Lund CM, "Effect of exercise on physical function and psychological wellbeing in older patients with colorectal cancer receiving chemotherapy—a systematic review", Clin Colorectal Cancer, 19, pp.e243~e257 (2020)
  42. Dun L, "Effects of moderate-to-vigorous physical activity on cancer-related fatigue in patients with colorectal cancer : a systematic review and meta-analysis", Arch Med Res, 51, pp.173~179 (2020)
  43. Lopez P, "Resistance training in breast cancer patients undergoing primary treatment : a systematic review and meta-regression of exercise dosage", Breast Cancer, 28, pp.16~24 (2021)
  44. Courneya KS, "Exercise as cancer treatment : a clinical oncology framework for exercise oncology research", Front Oncol, 12, pp.957135~ (2022)
  45. Bland KA, "Impact of exercise on chemotherapy completion rate : a systematic review of the evidence and recommendations for future exercise oncology research", Crit Rev Oncol Hematol, 136, pp.79~85 (2019)
  46. Courneya KS, "Effects of exercise during adjuvant chemotherapy on breast cancer outcomes", Med Sci Sports Exerc, 46, pp.1744~1751 (2014)
  47. van Waart H, "Effect of low-intensity physical activity and moderate-to high-intensity physical exercise during adjuvant chemotherapy on physical fitness, fatigue, and chemotherapy completion rates : results of the PACES randomized clinical trial", J Clin Oncol, 33, pp.1918~1927 (2015)
  48. An KY, "Exercise and health-related fitness predictors of chemotherapy completion in breast cancer patients : pooled analysis of two multicenter trials", Breast Cancer Res Treat, 188, pp.399~407 (2021)
  49. Van Vulpen JK, "Effects of an exercise program in colon cancer patients undergoing chemotherapy", Med Sci Sports Exerc, 48, pp.767~775 (2016)
  50. Morielli AR, "Feasibility, safety, and preliminary efficacy of exercise during and after neoadjuvant rectal cancer treatment : a phase II randomized controlled trial", Clin Colorectal Cancer, 20, pp.216~226 (2021)
  51. Stout NL, "A systematic review of exercise systematic reviews in the cancer literature(2005-2017)", PM R, 9(9S2), pp.S347~S384 (2017)
  52. Courneya KS, "Physical activity and cancer control", Semin Oncol Nurs, 23, pp.242~252 (2007)
  53. Spence RR, "Exercise and cancer rehabilitation : a systematic review", Cancer Treat Rev, 36, pp.185~194 (2010)
  54. Loh SY, "Methods to improve rehabilitation of patients following breast cancer surgery : a review of systematic reviews", Breast Cancer(Dove Med Press), 7, pp.81~98 (2015)
  55. Olsson Möller U, "A comprehensive approach to rehabilitation interventions following breast cancer treatment-a systematic review of systematic reviews", BMC Cancer, 19, pp.472~ (2019)
  56. Gao R, "Exercise intervention for post-treatment colorectal cancer survivors : a systematic review and meta-analysis", J Cancer Surviv, 14, pp.878~893 (2020)
  57. Ballard-Barbash R, "Physical activity, biomarkers, and disease outcomes in cancer survivors : a systematic review", J Natl Cancer Inst, 104, pp.815~840 (2012)
  58. Patel AV, "American College of Sports Medicine roundtable report on physical activity, sedentary behavior, and cancer prevention and control", Med Sci Sports Exerc, 51, pp.2391~2402 (2019)
  59. Friedenreich CM, "Prospective cohort study of pre-and postdiagnosis physical activity and endometrial cancer survival", J Clin Oncol, 38, pp.4107~4117 (2020)
  60. Tarasenko YN, "Muscle-strengthening and aerobic activities and mortality among 3+ year cancer survivors in the U. S", Cancer Causes Control, 29, pp.475~484 (2018)
  61. Rock CL, "American Cancer Society nutrition and physical activity guideline for cancer survivors", CA Cancer J Clin, 72, pp.230~262 (2022)
  62. Gleeson M, "The anti-inflammatory effects of exercise : mechanisms and implications for the prevention and treatment of disease", Nat Rev Immunol, 11, pp.607~615 (2011)
  63. Mathur N, "Exercise as a mean to control low-grade systemic inflammation", Mediators Inflamm, 2008, pp.109502~ (2008)
  64. Pedersen BK, "Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases", Scand J Med Sci Sports, 25(Suppl 3), pp.1~72 (2015)
  65. Ligibel JA, "Impact of a pre-operative exercise intervention on breast cancer proliferation and gene expression : results from the pre-operative health and body(PreHAB)study", Clin Cancer Res, 25, pp.5398~5406 (2019)
  66. Ashcraft KA, "Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis : a critical systematic review of in vivo preclinical data", Cancer Res, 76, pp.4032~4050 (2016)
  67. Kang DW, "Effects of exercise on insulin, IGF axis, adipocytokines, and inflammatory markers in breast cancer survivors : a systematic review and metaanalysis", Cancer Epidemiol Biomarkers Prev, 26, pp.355~365 (2017)
  68. Wang Y, "The effects of exercise on insulin, glucose, IGF-axis and CRP in cancer survivors : meta-analysis and meta-regression of randomised controlled trials", Eur J Cancer Care(Engl), 29, pp.e13186~ (2020)
  69. Yang L, "Effects of exercise on cancer treatment efficacy : a systematic review of preclinical and clinical studies", Cancer Res, 81, pp.4889~4895 (2021)
  70. Sanft T, "Randomized trial of exercise and nutrition on chemotherapy completion and pathologic complete response in women with breast cancer : the lifestyle, exercise, and nutrition early after diagnosis study", J Clin Oncol, 41, pp.5285~5295 (2023)
  71. Jones LW, "Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer", J Appl Physiol(1985), 113, pp.263~272 (2012)
  72. Bongers BC, "Enhanced recovery after surgery programmes in older patients undergoing hepatopancreatobiliary surgery : what benefits might prehabilitation have?", Eur J Surg Oncol, 47(3 Pt A), pp.551~559 (2021)
  73. Zhao T, "Effect of aerobic exercise on serum metabolites in mice with hepatocellular carcinoma after surgery", Med Sci Monit, 25, pp.3181~3189 (2019)
  74. Hilfiker R, "Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment : a systematic review incorporating an indirect-comparisons metaanalysis", Br J Sports Med, 52, pp.651~658 (2018)
  75. McNeely ML, "Predictors of adherence to an exercise program for shoulder pain and dysfunction in head and neck cancer survivors", Support Care Cancer, 20, pp.515~522 (2012)
  76. Kim DS, "The potential of physical exercise to mitigate radiation damage-a systematic review", Front Med(Lausanne), 8, pp.585483~ (2021)
  77. Kang DW, "Exercise cardio-oncology : exercise as a potential therapeutic modality in the management of anthracycline-induced cardiotoxicity", Front Cardiovasc Med, 8, pp.805735~ (2022)
  78. Dieli-Conwright CM, "Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer : a randomized controlled trial", J Clin Oncol, 36, pp.875~883 (2018)
  79. Bigaran A, "The effect of exercise training on cardiometabolic health in men with prostate cancer receiving androgen deprivation therapy : a systematic review and meta-analysis", Prostate Cancer Prostatic Dis, 24, pp.35~48 (2021)
  80. Kang DW, "Associations between physical activity and comorbidities in Korean cancer survivors", J Cancer Surviv, 12, pp.441~449 (2018)
  81. Falck RS, "Impact of exercise training on physical and cognitive function among older adults : a systematic review and meta-analysis", Neurobiol Aging, 79, pp.119~130 (2019)
  82. Mustian KM, "Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue : a meta-analysis", JAMA Oncol, 3, pp.961~968 (2017)
  83. Campbell KL, "Exercise guidelines for cancer survivors : consensus statement from international multidisciplinary roundtable", Med Sci Sports Exerc, 51, pp.2375~2390 (2019)

관련 논문AI추천

이 간행물의 다른 논문 (6건)