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블라스팅과 양극산화된 티타늄 표면이 조골세포의 부착 및 분화에 미치는 영향

Effect of Blasted or Anodized Titanium Surface Roughness on Adhesion and Differentiation of Osteoblasts

고성희|조리라|엄흥식|장범석|박찬진
대한턱관절교합학회 (Korean academy of stomatognathic function and occlusion)|2006.09|구강회복응용과학지 (Journal of Dental Rehabilitation and Applied Science)|제22권 제3호|pp. 261-270

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참고문헌

주제분류치의학

초록

Abstract

Effect of Blasted or Anodized Titanium Surface Roughness on Adhesion and Differentiation of Osteoblasts Chan-Jin Park*, Lee-Ra Cho*, Yang-Jin Yi*, Sung-Hee Ko** *Department of Prosthodontics, **Department of Pharmacology College of Dentistry, Kangnung National University and Oral Science Institute The success of an implant is determined by its integration into the tissue surrounding the biomaterial. Surface roughness is considered to influence the behavior of adherent cells. The aim of this in vitro study was to determine the effect of surface roughness on Saos-2 osteoblast-like cells. Titanium disks, blasted with 75 ㎛ aluminum oxide particles and anodic oxidized and machined titanium disks were prepared. Saos-2 were plated on the disks at a density of 50,000 cells per well in 48-well dishes. After 1 hour, 1 day, 6 days cell numbers were counted. One day, 6 days after plating, alkaline phosphatase(ALPase) activity was determined. Compared to experimental groups, the number of cells was significantly higher on control group. The stimulatory effect of surface roughness on ALPase was more pronounced on the experimental groups than on control group. These results demonstrate that surface roughness alters proliferation and differentiation of osteoblasts. The results also suggest that implant surface roughness may play a role in determining phenotypic expression of cells.

참고문헌 (35)

  1. "Aspect of surface physics on titanium implants"
  2. "Surface spectroscopic characterization of titanium implant materials", 45, pp.133~46 (1990)
  3. "Surface analysis of four dental implant systems", 8, pp.32~40 (1993)
  4. "On tissue reactions to metal implants University of Gteborg" (1991)
  5. "Optimization of surface micromorphology for enhanced osteoblast responses in vitro", 7, pp.302~10 (1992)
  6. "In vitro cell attachment of osteoblast-like cells to titanium", 68, pp.276~ (1989)
  7. "Titanium surface roughness alters responsiveness of MG63 oteoblast-like cells to 1 , 25-(OH)2D3", 39, pp.77~85 (1998)
  8. "Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies", 6, pp.22~27 (2003)
  9. "Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells(MG63)", 29, pp.389~401 (1995)
  10. "Attachment and growth of periodontal cells on smooth and rough-titanium", 9, pp.289~97 (1994)
  11. "Prostaglandins mediate the effects of titanium surface roughness on MG63 osteoblast-like cells and alter cell responsiveness to 1 alpha,25-(OH)2D3", 41, pp.489~496 (1998)
  12. "Inhibition of cyclooxygenase by indomethacin modulates osteoblast response to titanium surface roughness in a time-dependent manner", 12, pp.52~61 (2001)
  13. "Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG63 cells", 32, pp.55~63 (1996)
  14. "Local factor production by MG63 osteoblast-like cells in response to surface roughness and 1 , 25-(OH)2D3 is mediated via protein kinase C- and protein kinase A-dependent pathways", 22, pp.731~741 (2001)
  15. "Minireview", 142, pp.5050~5055 (2001)
  16. "Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity", 70, pp.361~369 (2004)
  17. "Fibroblasts on micromachined substrata orient hierarchically to grooves of different dimensions", 164, pp.11~26 (1986)
  18. "An evaluation of variables influencing implant fixation and direct bone appostition", 19, pp.875~901 (1985)
  19. "Influence of surface characteristics on bone integration of titanium implants:A histomorphometric study in miniature pigs", 25, pp.889~902 (1991)
  20. "Removal torques for polished and rough titanium implants", 3, pp.21~24 (1988)
  21. "Effects of surface roughness of titanium implants on bone remodeling activity of remour in rabbits", 21, pp.507~514 (1997)
  22. "The relation between surface roughness and interfacial shear strength for bone-anchored implants", 32, pp.829~836 (1999)
  23. "Anomalous preferences of cultured macrophages for hydrophobic and roughened substrata", 50, pp.1~7 (1981)
  24. "The influence of various titanium surfaces on the interface shear strength between implants and bone Advances in Biomaterials", pp.309~314, S Steineman in Clinical Implant Materials
  25. "The long-term efficacy of currently used dental implants", 1, pp.11~25 (1986)
  26. "Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition", pp.2219~2232 (1998)
  27. "Different titanium surface treatment infuences human mandibular osteoblast response", 75, pp.273~282 (2004)
  28. "Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3", 15, pp.1169~1180 (2000)
  29. "Bone regulating mechanism on implant surfaces", pp.41~54 (1999)
  30. "Qualitative and quantitative study of human osteoblast adhesion on materials with various surface roughness", 49, pp.155~166 (2000)
  31. "Initial interaction of rat bone marrow cells with non-coated and calcium phosphate coated titanium substrates", 23, pp.3269~3277 (2002)
  32. "Oxidised implants and their influence on the bone response", 12, pp.1025~1031 (2001)
  33. "Bone reactions to oxidized titanium implants with electrochemically anion S and P incorporation", 4, pp.478~487 (2002)
  34. "Oxidized titanium screws coated with calcium ions and their performance in rabbit bone", 17, pp.625~634 (2002)
  35. "The significance of the surface properties of oxidized titanium to the bone response", 24, pp.3893~3907 (2003)

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