혈액중 PCBs 이성질체별 분석에 의한 인체 노출평가
Evaluation for human exposure to polychlorinated biphenyls using human serum by congener-specific analysis
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Abstract
Blood serum concentrations of polychlorinated biphenyls (PCBs) were measured in employees whoworked at a municipal solid waste incinerator (MSWI), members of residential comunity who lived near theMSWI (<0.3km) and members of residential comunity lived far from the MSWI (>10 km). Human blodserum samples were analyzed for all PCB congeners using high-resolution gas chromatography/high-resolutionmass spectrometry (HRGC/HRMS). The mean levels of total PCBs and dioxin-like PCBs in 87 serum sampleshexa-, hepta-chlorinated biphenyls contributed more than 80% of the total PCBs concentration. The mostabundant congeners were PCB153, PCB138, PCB180, PCB187, PCB118. A statistical analysis was performedto determine whether there were significant correlations between PCB concentrations and specific variables suchas age, gender, smoking habits, occupation, BMI (Body Mass Index) and time of residence. As a result, theage was found to be strongly correlated with serum PCB concentrations. In addition, there were strong. Corresponding authorPhone : +82-(0)54-279-2281 Fax : +82-(0)54-279-8299E-mail: yschang@postech.ac.kr74 .......................Analytical Science & Technologycorrelations between total PCBs and PCB153 (r=0.93, p<.0001), dioxin-like PCBs and PCB118 (r=0.98,p<.0001). So these two congeners are satisfactory indicators for total PCB concentrations and dioxin-like PCBsin human blood respectively.
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