Molecular epidemiologic trends of norovirus and rotavirus infection and relation with climate factors: Cheonan, Korea, 2010-2019
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Background: Viral infection outbreaks are emerging public health concerns. They often exhibit seasonal patterns that could be predicted by the application of big data and bioinformatic analyses. Purpose: The purpose of this study was to identify trends in diarrhea-causing viruses such as rotavirus (Gr.A), norovirus G-I, and norovirus G-II in Cheonan, Korea. The identified related factors of diarrhea-causing viruses may be used to predict their trend and prevent their infections. Method: A retrospective analysis of 4,009 fecal samples from June 2010 to December 2019 was carried out at Dankook University Hospital in Cheonan. Reverse transcription-PCR (RT-PCR) was employed to identify virus strains. Information about seasonal patterns of infection was extracted and compared with local weather data. Results: Out of the 4,009 fecal samples tested using multiplex RT-PCR (mRT-PCR), 985 were positive for infection with Gr.A, G-I, and G-II. Out of these 985 cases, 95.3% (n = 939) were under 10 years of age. Gr.A, G-I, and G-II showed high infection rates in patients under 10 years of age. Student's t-test showed a significant correlation between the detection rate of Gr.A and the relative humidity. The detection rate of G-II significantly correlated with wind-chill temperature. Conclusion: Climate factors differentially modulate rotavirus and norovirus infection patterns. These observations provide novel insights into the seasonal impact on the pathogenesis of Gr.A, G-I, and G-II.
Abstract
Background: Viral infection outbreaks are emerging public health concerns. They often exhibit seasonal patterns that could be predicted by the application of big data and bioinformatic analyses. Purpose: The purpose of this study was to identify trends in diarrhea-causing viruses such as rotavirus (Gr.A), norovirus G-I, and norovirus G-II in Cheonan, Korea. The identified related factors of diarrhea-causing viruses may be used to predict their trend and prevent their infections. Method: A retrospective analysis of 4,009 fecal samples from June 2010 to December 2019 was carried out at Dankook University Hospital in Cheonan. Reverse transcription-PCR (RT-PCR) was employed to identify virus strains. Information about seasonal patterns of infection was extracted and compared with local weather data. Results: Out of the 4,009 fecal samples tested using multiplex RT-PCR (mRT-PCR), 985 were positive for infection with Gr.A, G-I, and G-II. Out of these 985 cases, 95.3% (n = 939) were under 10 years of age. Gr.A, G-I, and G-II showed high infection rates in patients under 10 years of age. Student's t-test showed a significant correlation between the detection rate of Gr.A and the relative humidity. The detection rate of G-II significantly correlated with wind-chill temperature. Conclusion: Climate factors differentially modulate rotavirus and norovirus infection patterns. These observations provide novel insights into the seasonal impact on the pathogenesis of Gr.A, G-I, and G-II.
참고문헌 (27)
- 강윤구, "한국 단일기관 응급실을 방문한 소아환자에서 급성위장염 발생과 지역 기온의 상관관계", 대한소아응급의학회지, 5(1), pp.19~24 (2018), 대한소아응급의학회[DOI]
- J. I. Song, "Comparison of clinical features between noroviral and rotaviral gastroenteritis", Soonchunhyang Medical Science, 23(1), pp.29~33 (2017)[DOI]
- N. Ouedraogo, "Temporal distribution of gastroenteritis viruses in Ouagadougou, Burkina Faso : seasonality of rotavirus", BMC Public Health, 17, pp.274~ (2017)[DOI]
- M. Ghazani, "Temperature Variability and Gastrointestinal Infections : A Review of Impacts and Future Perspectives", International Journal of Environmental Research and Public Health, 15(4), pp.766~ (2018)[DOI]
- 김영상, "2015년부터 2018년까지 일개 이차병원에서 동정된 소아 급성 위장염 원인 병원체의 분자진단과 역학의 임상적 연구", Pediatric Infection and Vaccine, 27(2), pp.90~101 (2020), 대한소아감염학회[DOI]
- J. K. Kim, "Molecular epidemiologic trends of diarrhea-causing virus infection from clinical specimens in Cheonan, Korea, in 20102012", Journal of Clinical Laboratory Analysis, 28, pp.47~51 (2014)
- 이승현, "영아를 위한 어머니의 로타바이러스 예방접종 이행과 관련 요인: 건강신념모형을 중심으로", 한국보건간호학회지, 31(1), pp.34~46 (2017), 한국보건간호학회
- S. S. Chenar, "Environmental indicators for human norovirus Outbreaks", International Journal of Environmental Health Research, 27(1), pp.40~51 (2017)[DOI]
- 박지온, "Epidemiologic Trends of Diarrhea-causing Virus Infection Analyzed by Multiplex Reverse Transcription PCR in Cheonan, Korea, 2010-2018", 한국미생물·생명공학회지, 47(2), pp.317~322 (2019), 한국미생물·생명공학회[DOI]
- GBD 2016 Diarrhoeal disease collaborators., "Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015", Lancet Infectious Diseases, 17, pp.909~948 (2017)[DOI]
- A. J. Hall, "Norovirus disease in the United States", Emerging Infectious Diseases, 19(8), pp.1198~2105 (2013)[DOI]
- K. M. Guarines, "Norovirus-associated gastroenteritis, Pernambuco, Northeast Brazil, 2014-2017", Journal of Medical Virology, 92(8), pp.1093~1101 (2019)[DOI]
- 윤정민, "로타바이러스 백신 도입 후 소아 입원 환자에서의로타바이러스 위장관염 발생 변화 및 로타바이러스백신 효과 추정", Pediatric Infection and Vaccine, 25(1), pp.26~34 (2018), 대한소아감염학회[DOI]
- Y. G. Karim, "Effect of relative humidity on the airborne survival of rhinovirus-14", Canadian Journal of Microbiology, 31, pp.1058~1061 (1985)[DOI]
- W. S. Miller, "Aerosol stability of three acute respiratory disease viruses", Proceedings of the Society for Experimental Biology and Medicine, 125, pp.222~227 (1967)
- C. B. Hall., "The spread of influenza and other respiratory viruses : complexities and conjectures", Clinical Infectious Diseases, 45, pp.353~359 (2007)[DOI]
- 김수경, "호흡기 바이러스의 동역학 연구와 감염관리", 의료관련감염관리, 23(1), pp.1~7 (2018), 대한의료관련감염관리학회
- Cha-Shien Yen, "Detection of norovirus and rotavirus among inpatients with acute gastroenteritis in a medical center in northern Taiwan, 2013–2018", Journal of Microbiology, Immunology and Infection, 53(6), pp.955~962 (2020), Elsevier BV[DOI]
- 정무상, "Multiplex PCR을 이용한 제주도 성인의 급성 설사 원인체에 관한 역학조사", Annals of Clinical Microbiology, 21(1), pp.1~7 (2018), 대한임상미생물학회
- 최미란, "노로바이러스 및 로타바이러스 위장염과 동반된 양성경련의 비교", 대한소아신경학회지, 24(3), pp.95~101 (2016), 대한소아신경학회[DOI]
- 고복실, "대구지역 급성설사질환 원인병원체 검출률과 기후요소와의 상관성 변화", 보건정보통계학회지, 44(1), pp.32~40 (2019), 한국보건정보통계학회[DOI]
- Khitam Muhsen, "No evidence of an increase in the incidence of norovirus gastroenteritis hospitalizations in young children after the introduction of universal rotavirus immunization in Israel", Human Vaccines & Immunotherapeutics, 15(6), pp.1284~1293 (2018), Informa UK Limited[DOI]
- 김종규, "우리나라에서 지난 10년간 노로바이러스 식중독 발생의 특징과 기후요소와의 관련성", 한국환경보건학회지, 45(6), pp.622~629 (2019), 한국환경보건학회
- Y. S. Kim, "Correlations between climatic conditions and foodborne disease", Food Research International, 68, pp.24~30 (2014)[DOI]
- I. Samandoulgou, "Stability of secondary and tertiary structures of virus-like particles representing noroviruses : effects of pH, ionic strength, and temperature and implications for adhesion to surfaces", Applied Environmental Microbiology, 81, pp.7680~7686 (2015)[DOI]
- 서검석, "설사(급성 감염성 설사를 중심으로)", 대한내과학회지, 78(1), pp.49~53 (2010), 대한내과학회
- P. Wang, "A time-series study of the association of rainfall, relative humidity and ambient temperature with hospitalizations for rotavirus and norovirus infection among children in Hong Kong", Science of the Total Environment, 643, pp.414~422 (2018)[DOI]