논문KCI 등재
측두하악관절에 발생한 골연골종에 대한 고찰
Review of osteochondroma: involved in temporomandibular joint
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
주제분류치의학
초록
골연골종은 가장 흔한 양성 골종양으로 단독성 골연골종과 유전성-다발성 골연골종으로 분류되고, 대부분 단독성으로 알려져 있다. 대개 무증상이나, 측두하악관절에 이환 되면 안면 비대칭, 부정교합, 교차교합과 개구 제한 등이 발생할 수 있다. 방사선학적 평가가 진단 시 가장 중요하며, 유전성-다발성 골연골종은 exostosis(multiple)-1 (EXT1) 유전자의 이중 대립형질 비활성과 염색체 8q24.11 - q24,13 나 11p11 - 12에 위치한 exostosis(multiple)-2 (EXT2)유전자의 변형이 관찰된다. 비유전성 골연골종의 경우 EXT1 유전자의 mRNA 가 감소된다. 골연골종의 치료 방법은 외과적 절제이고, 측두하악관절 부위와 같이 교합의 변화를 수반하는 경우 외과적 절제술 이외에 악교정 수술을 필요로 할 수 있다.
Abstract
Osteochondroma is the most common benign bone tumor. The majority of osteochondromas (85%) present as solitary, nonhereditary lesions. In general, osteochondroma has no symptoms ,however, facial asymmetry, malocclusion, crossbite and mouth opening can be occurred in case of temporomandibular joint involved. Radiologic analyses are indispensable element to diagnose osteochondroma and pathogenetic analysis showed that hereditary multiple osteochondromas are caused by mutations in either of two genes: exostosis(multiple)-1 (EXT1), which is located on chromosome 8q24.11 - q24.13 or exostosis(multiple)-2 (EXT2), which is located on chromosome 11p11 - 12. Recently, reduced mRNA of EXT1 was described in nonhereditary osteochondromas. The treatment of choice for osteochondroma is surgical unless the skeleton is still immature. Surgery associated with orthodontic treatment can be a valid approach to minimize facial asymmetry and malocclusion in case of temporomandibular with osteochondroma.
참고문헌 (45)
- Saglik Y, "Manifestations and management of osteochondromas: a retrospective analysis of 382 patients", Acta Orthop Belg, 72, pp.748~755 (2006)
- Canella P, "Exostosis: development, evolution and relationship to malignant degeneration", Ital J Orthop Traumatol, 7, pp.293~298 (1981)
- Thoma KH, "Tumors of the condyle and temporomandibular joint", Oral Surg Oral Med Oral Pathol, 7, pp.1091~1107 (1954)
- Peterson HA, "Multiple hereditary osteochondromata", Clin Orthop Relat Res, 239, pp.222~230 (1989)
- Seibert JJ, "A primary rib tumor in a newborn", J Pediatr Surg, 11, pp.1031~1032 (1976)
- Wood VE, "The treatment of hereditary multiple exostosis of the upper extremity", J Hand Surg Am, 10, pp.505~513 (1985)
- Morton KS, "On the question of recurrence of osteochondroma", J Bone Joint Surg BR, 46, pp.723~725 (1964)
- Hennekam RC, "Hereditary multiple exostoses", J Med Genet, 28, pp.262~266 (1991)
- Nawata K, "Knee deformities in multiple hereditary exostoses: a longitudinal radiographic study", Clin Orthop Relat Res, 313, pp.194~199 (1995)
- Murphey MD, "Imaging of osteochondroma: variants and complications with radiologio-pathologic correlation", Radiographics, 20, pp.1407~1434 (2000)
- Chrisman OD, "Untreated solitary osteochondroma. Report of two cases", J Bone Joint Surg Am, 50, pp.508~512 (1968)
- Van Oost J, "Compartment syndrome associated with an osteocartilaginous exostosis", Acta Orthop Belg, 62, pp.233~235 (1996)
- Pandya NK, "Spinal cord compression in a patient with multiple hereditary exostoses caused by breast adenocarcinoma metastatic to osteochondromas of the spine: case report", Spine, 31, pp.920~924 (2006)
- Koga M, "Osteochondroma in the mandibular condyle that caused facial asymmetry: a case report", Cranio, 24, pp.67~70 (2006)
- Koehl GL, "Osteochondromas associated with facial asymmetry and masticatory dysfunction: report of two cases", J Oral Surg, 35, pp.934~939 (1977)
- Hudson TM, "Benign exostoses and exostotic chondrosarcomas: evaluation of cartilage thickness by CT", Radiology, 152, pp.595~599 (1984)
- Malghem J, "Benign osteochondromas and exostosis chondrosarcomas: evaluation of cartilage cap thikness by ultrasound", Skeletal Radiol, 21, pp.33~37 (1992)
- Hudson TM, "Scintigraphy of benign exostoses and exostotic chondrosarcomas", AJR Am J Roentgenol, 140, pp.581~586 (1983)
- Matsushita M, "Pseudoaneurysm of the popliteal artery caused by exostosis of the femur: case report and review of the literature", J Vasc Surg, 32, pp.201~204 (2000)
- Mehta M, "MR imaging of symptomatic osteochondromas with pathological correlation", Skeletal Radiol, 27, pp.427~433 (1998)
- Karasick D, "Symptomatic osteochondromas: imaging features", AJR Am J Roentgenol, 168, pp.1507~1512 (1997)
- Geirnaerdt MJ, "Cartilaginous tumors: correlation of gadolinium-enhanced MR imaging and histopathologic findings", Radiology, 186, pp.813~817 (1993)
- Woertler K, "Osteochondroma: MR imaging of tumor-related complications", Eur Radiol, 10, pp.832~840 (2000)
- Uri DS, "Muscle impingement: MR imaging of a painful complication of osteochondromas", Skeletal Radiol, 25, pp.689~692 (1996)
- Giudici MA, "Cartilaginous bone tumors", Radiol Clin North Am, 31, pp.237~259 (1993)
- Griffiths HJ, "Bursitis in association with solitary osteochondromas presenting as mass lesions", Skeletal Radiol, 20, pp.513~516 (1991)
- Wicklund LC, "Natural history study of hereditary multiple exostoses", Am J Med Genet, 55, pp.43~46 (1995)
- Schmale GA, "The natural history of hereditary multiple exostoses", J Bone Joint Surg Am, 76, pp.986~992 (1994)
- Cotran RS, "Robbins Pathologic Basis of Disease", pp.1237~1238 (1999), WB Saunders
- Bovée JV, "Intermediate grade osteosarcoma and chondrosarcoma arising in an osteochondroma: a case report of a patient with hereditary multiple exostoses", J Clin Pathol, 55, pp.226~229 (2002)
- Ahn J, "Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)", Nat Genet, 11, pp.137~143 (1995)
- Wuyts W, "Positional cloning of a gene involved in hereditary multiple exostoses", Hum Mol Genet, 5, pp.1547~1557 (1996)
- Stickens D, "The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes", Nat Genet, 14, pp.25~32 (1996)
- Zak BM, "Hereditary multiple exostoses and heparan sulfate polymerization", Biochim Biophys Acta, 1573, pp.346~355 (2002)
- Hecht JT, "Heparan sulfate abnormalities in exostosis growth plates", Bone, 31, pp.199~204 (2002)
- Bernard MA, "Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes", Cell Motil Cytoskeleton, 48, pp.149~162 (2001)
- Bertoni F, "Pathology and genetics of tumours of soft tissue and bone", pp.247~251 (2002), IARC
- Tsuchiya T, "Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma", Cancer Genet Cytogenet, 158, pp.148~155 (2005)
- Hameetman L, "Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas", J Pathol, 211, pp.399~409 (2007)
- Knudson CB, "Cartilage proteoglycans", Semin Cell Dev Biol, 12, pp.69~78 (2001)
- Selleck SB, "Proteoglycans and pattern formation. Sugar biochemistry meets developmental genetics", Trends Genet, 16, pp.206~212 (2000)
- Esko JD, "Order out of chaos: assembly of ligand-binding sites in heparan sulfate", Annu Rev Biochem, 71, pp.435~471 (2002)
- Porter DE, "The neoplastic pathogenesis of solitary and multiple osteochondromas", J Pathol, 188, pp.119~125 (1999)
- Markove RC, "Cartilaginous tumors of the ribs", Cancer, 27, pp.794~801 (1971)
- Kumar A, "Osteochondroma of the mandibular condyle", Indian J Dent Res, 22, pp.616~ (2011)
관련 논문AI추천
하악골 하연에 발생한 골연골종: 증례보고남웅, 길태준, 김소미, 김재영, 김학진대한구강악안면외과학회 · 대한구강악안면외과학회지2010 · 제36권 제3호Osteochondroma of the mandibular condyle with secondary synovial chondromatosis김경아치의학연구원 · Oral Biology Research2018 · 제42권 제3호Surgical approach and orthodontic treatment of mandibular condylar osteochondroma김정기, Nam Hyung Chung, So Jin Yang, Young-Mi Jeon대한치과교정학회 · 대한치과교정학회지2020 · 제50권 제3호Conservative condylectomy alone for the correction of mandibular asymmetry caused by osteochondroma of the mandibular condyle: a report of five case김재영, 박광호, 허종기, Chan-Woo Jeong, Dong Sung Kim대한구강악안면외과학회 · 대한구강악안면외과학회지2015 · 제41권 제5호하악 과두에 발생한 골연골종의 보존적 제거 1 예남웅, 김재영, 김학진, 김형준, 남정우, 차인호대한구강악안면외과학회 · 대한구강악안면외과학회지2009 · 제35권 제4호Giant osteochondroma of the parapharyngeal space: a case report김철환, 이윤선대한구강악안면외과학회 · 대한구강악안면외과학회지2013 · 제39권 제1호