본문 바로가기
KERD
논문KCI 등재

정규 제왕절개술시 항생제 사용에 있어서 제대 결찰후예방적 1회 투여요법과 기존의 수술 후 다회 투여요법과의 술후 합병증 발생에 대한 비교연구

Comparative Study of Single-dose Prophylactic Antibiotics after Cord Clamping Vs. Multi-dose Postoperative Antibiotics in Operative Complications after Elective Cesarean Section

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류산부인과학

초록

목적 : 정규 제왕절개술 후 감염을 예방하는 데 있어서 제대결찰 후 Cefazolin을 1회 투여한 군과 수술 후 Cefazolin 다회요법을 시행한 군을 대조군으로 하여 수술 후 합병증 발생 유무를 비교하였다. 연구 방법 : 총 90명의 산모를 대상으로 1 g의 Cefazolin을 제대결찰 후 1회 투여한 실험군과 수술 후 2일간 4회의 1 g Cefazolin을 투여 받고 이후 경험적으로 경구항생제를 5일간 투여 받은 대조군으로 나누어, 열성이환을 알아보았으며 이후 감염과 관련된 합병증들의 발생을 알아보았다. 결과 : 연구군과 대조군 사이에 평균 재원 일수의 차이를 보이지 않았고 그 외 열성 이환, 자궁내막염, 수술부위 감염, 요로 감염 등에 있어서 유의한 차이를 보이지 않았다. 또한 수술 후 3일째 시행한 hemoglobin 수치, WBC 수치, ESR, CRP 수치에 있어서도 유의한 차이를 보이지 않았다. 결론 : 정규 제왕절개술을 시행하는 경우 Cefazolin 1 g을 제대결찰 후 1회 투여하는 것은 수술 후 경험적으로 항생제를 다회 사용하는 방법과 비교하여 열성이환 및 감염과 관련된 수술 후 합병증의 발생에 별다른 차이를 보이지 않았다.

Abstract

Objective : To compare single-dose prophylactic antibiotics after cord clamping with multi-dose postoperative antibiotics in operative complications after elective cesarean section. Methods : Forty-five women undergoing elective cesarean section had 1g cefazolin administration after umbilical cord clamping. Forty-five women was control group who had antibiotics administration postoperatively 4 times 1 g cefazolin and 5 days more per oral. Postoperative complication including febrile morbidity, wound infection, endometritis, urinary tract infection, pneumonia were recorded, as were the duration of hospital stay and the need for therapeutic antibiotics. Results : Postoperative complication incuding febrile morbidity, wound infection, endometritis, urinary tract infection, pneumonia had no difference between two groups significantly. Also, their hospital stay had no difference significantly. Conclusion : Single-dose prophylactic antibiotics administration after cord clamping in elective cesarean section is considered to have no difference in comparison with multi-dose post-operative administration. Single-dose prophylactic antibiotics administration after cord clamping will reduce side effect of drugs and resistance. Also it will provide better cost effectiveness.

참고문헌 (34)

  1. "The cesarean birth epidemic: trends, causes, and solutions", pp.369~374 (1996)
  2. "제왕절개술 빈도의 변화 양상", 41(3), pp.647~652 (1998)
  3. "Incidence of hospital-acquired infections associated with cesarean section", 29, pp.245~255 (1995)
  4. "Clinical risk factors for pueperal infection", 55, pp.178~184 (1980)
  5. "The use of prophylactic antibiotics in obstetrics and gynecology. A review", 39, pp.537~554 (1984)
  6. "Effects of prophylactic antibiotics on endometrial flora in women with postcesarean endometritis", 92, pp.262~268 (1998)
  7. "The prophylactic use of metronidazole in cesarean section", 92, pp.153~165 (1980)
  8. "Antibiotic prophylaxis in surgery:summary of a Swedish-Norwegian Consensus Conference", 30, pp.547~557 (1998)
  9. "Antibiotic prophylaxis Regimens and Drugs for Cesarean section ( Cochrane Review). In: The Cochrane Library Issue 3" (2002), Update Software
  10. "Prophylactic cesarean section antibiotics:maternal and neonatal morbidity before or after cord clamping", 53, pp.151~6 (1979)
  11. "Perioperative antimicrobials for cesarean delivery:before or after cord clamping", 62, pp.151~154 (1983)
  12. "The use of prophylactic antibiotics in cesarean section:a review of the literature", 26, pp.595~609 (1981)
  13. "Cost-effective use of antibiotic prophylaxis for cesarean section", 157, pp.506~510 (1987)
  14. "Reducing the incidence of infection after caesarean section:implications of prophylaxis with antibiotics for hospital resources", 299, pp.1003~6 (1989)
  15. "Systemic antibiotic prophylaxis in elective cesarean delivery", pp.245~251 (1998)
  16. "Clinical infection in Obstetrics and Gynecology", pp.195~209 (1990), Blackwell Scientific Publications
  17. "The use of prophylactic antibiotics in cesarean section A review of literature", 23, pp.595~609 (1981)
  18. "A double blind randomized controlled trial on the use of prophylactic antibiotics in women undergoing elective cesarean section", 95, pp.689~692 (1988)
  19. "Risk factors for postcesarean surgical site infection", 95, pp.367~371 (2000)
  20. "A randomized controlled trial of antibiotic prophylaxis in elective caesarean delivery", 108, pp.143~148 (2001)
  21. "Antimicobial prophylaxis in obstetric and gynecological surgery", 11, pp.577~580 (1999)
  22. "New perspectives in antibiotic prophylaxis for obstetric and gynecological surgery", 50, pp.s13~s15 (2002)
  23. "Single dose cefazolin prophylaxis for post-cesarean infections: Before vs. after cord clamping", pp.61~65 (1997)
  24. "정규 제왕절개 수술시 예방적 항생제 요법에 관한 연구", 45(9), pp.1511~1515 (2002)
  25. "Short-versus long-course prophylactic antibiotic treatment in cesarean section patients", 55, pp.583~286 (1980)
  26. "Antibiotic prophylaxis for cesarean section.", 2 (2000)
  27. "ASHP therapeutic guidelines on antimicrobial prophylaxis in surgery", 56, pp.1839~1888 (1999)
  28. "Prophylaxis with tercef of infection-related complications after cesarean section", 42(2), pp.33~37 (2001)
  29. "The routine use of cefazolin in cesarean section", 69(2), pp.107~112 (2000)
  30. "Single dose cefazolin prophylaxis for postcesarean infections: before vs. after cord clamping", 6(1), pp.61~65 (1997)
  31. "Antimicrobial therapy for obstetric patients", 245 (1998), ACOG Tecnical Bull
  32. "Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: A meta-analysis", 184, pp.656~661 (2001)
  33. "Cesarean section:an economic appraisal of infectious complications", 20, pp.108~110 (1993)
  34. "v Infections complicating low risk cesarean sections in community hospital: efficacy of antimicribial prophylaxis A", 162, pp.337~373 (1990)

관련 논문AI추천

이 간행물의 다른 논문 (16건)