유전성 비용종성 대장직장암에 동반된자궁내막암 1예
A Case of Endometrial Cancer with Hereditary Non-Polyposis Colorectal Cancer (HNPCC)
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자궁내막암은 유전성 비용종성 대장직장암과 동반될 수 있는 가장 흔한 악성 질환이며 Lynch II 증후군으로 알려진 유전성 비용종성 대장직장암은 다른 장기, 특히 자궁내막에 암을 유발할 수 있는 상염색체 우성의 유전방식으로 유전되는 대장용종 질환이다. 유전성 비용종성 대장암 여성 환자에 있어서 자궁내막암의 평생위험률은 일반 여성의 3%의 비해 40- 60%로 높은 비율을 보인다. 이러한 자궁내막암의 평균 발생연령은 45세이고 종종 대장암보다 먼저 발병할 수 있다. 저자들은 최근 새롭게 발생한 유전성 비용종성 대장직장암 (de novo type of hereditary non-polyposis colorectal cancer)과 동반된 자궁내막암 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. ‘
Abstract
Endometrial cancer is the most common malignant disorder that can be associated with hereditary non-polyposis colorectal cancer (HNPCC), which is known as Lynch II syndrome. HNPCC is a polyposis of the colon which is inherited in an autosomal dominant pattern and can cause cancer in other organs, especially in the endometrium. The overall risk of a women with HNPCC to develop endometrial cancer is 40-60%, much higher than the 3% of the general population of women. The average age of developing endometrial cancer of a women with HNPCC is 45 years of age and is often found before development of colon cancer. We have recently experienced a case of de novo type of hereditary non-polyposis colorectal cancer associated with endometrial cancer, hence we are reporting this case with a brief review of literatures.
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