5-FU 연고로 치료한 절제면 양성 미세침윤성 외음부 파제트병 1예
A case of microinvasive Paget’s disease of the vulva: Treatment of positive resection margin with topical 5-FU cream application
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초록
외음부의 파제트병은 매우 드문 외음부종양으로 육안으로 보이는 병변을 넘어서는 미세병소 및 다발성 병소가 흔히 존재하여 광범위절제술 이후에 절제면 양성인 경우가 흔하고 높은 재발률을 보이는 것으로 알려져 있다. 저자들은 외음부 파제트병의 광범위절제술 이후 절제면 양성인 환자에게 5-FU 연고를 도포하여 완전한 관해를 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Extramammary Paget’ disease of the vulva is a rare lesion that accounts for 1~2% of vulvar neoplasms. Paget’ disease often has a microscopic extension beyond the gross lesion and shows a multifocal distribution. Positive resection margin is common. We applied 5-FU cream on the lesion who had a positive resection margin. There was no residual lesion on multiple punch biopsies after 5-FU cream treatment three months later. And there has been no evidence of disease recurrence in the 12-month follow-up period. We experienced a case of effective treatment with 5-FU cream in microinvasive Paget's disease of the vulva with positive resection margin. We present it with a brief review of literatures.
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