IS THE EXPRESSION OF P16INK4A AND GALECTIN‐3 CORRELATED WITH DISEASE PROGRESSION OF CERVICAL NEOPLASIA?
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Objective The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as a diagnostic tool. Methods Eighty-seven formalin-fixed paraffin-embedded cervical specimens (20 normal, 17 LSILs, 26 HSILs, 24 invasive cervical cancers) collected between 2005 and 2009 were selected. We examined the expression of p16INK4A and galectin-3 using immunohistochemical stains with the scoring system. Results The mean proportion of p16INK4A and galectin-3 was 0.1 and 1.70 in normal lesions, 1.35 and 2.17 in LSILs, 3.42 and 3.11 in HSILs,3.79 and 3.08 in invasive cancers. The mean proportion of p16INK4A and galectin-3 was correlated signifi cantly with the degree of neoplasia (P <0.05). Conclusion The increased immunohistochemical staining expressions of the p16INK4A and galectin-3 are associated with the progression of cervical neoplasia. Therefore immunohistochemical staining of p16INK4A and galectin-3 can be a useful biomarker for the diagnosis of a progression of cervical neoplasia.
Abstract
Objective The aim of this study is to investigate whether the expressions of p16INK4A and galectin-3 are associated with the progression of cervical neoplasia and to evaluate its usefulness as a diagnostic tool. Methods Eighty-seven formalin-fixed paraffin-embedded cervical specimens (20 normal, 17 LSILs, 26 HSILs, 24 invasive cervical cancers) collected between 2005 and 2009 were selected. We examined the expression of p16INK4A and galectin-3 using immunohistochemical stains with the scoring system. Results The mean proportion of p16INK4A and galectin-3 was 0.1 and 1.70 in normal lesions, 1.35 and 2.17 in LSILs, 3.42 and 3.11 in HSILs,3.79 and 3.08 in invasive cancers. The mean proportion of p16INK4A and galectin-3 was correlated signifi cantly with the degree of neoplasia (P <0.05). Conclusion The increased immunohistochemical staining expressions of the p16INK4A and galectin-3 are associated with the progression of cervical neoplasia. Therefore immunohistochemical staining of p16INK4A and galectin-3 can be a useful biomarker for the diagnosis of a progression of cervical neoplasia.
참고문헌 (25)
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