仙鶴草 추출물의 投與가 Streptozotocin으로 유발된 당뇨쥐에미치는 영향
Effects of Agrimoniae Herba Ledebour on steptozotocin-induced Diabetic Mellitus in Rats.
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Abstract
Objective : The present study was carried out to investigate the preventive effect of Agrimonia pilosa Ledebour on Streptozotocin(STZ)-induced Diabetes mellitus. Method : Agrimonia pilosa Ledebour was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of STZ-induced diabetic rats, sample group with Agrimonia pilosa Ledebour. The effect of Agrimonia pilosa Ledebour on STZ-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine. Result : STZ caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic β-cell. Agrimonia pilosa Ledebour treatment don't protected them from hyperglycemia and hypoinsulinemia. Organ weight only liver weight decreased but kidney, heart & spleen shows no significant changes. Agrimonia pilosa Ledebour significantly don't recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT & creatinine is vice versa. Conclusion : Agrimonia pilosa Ledebour extract group did not show significant difference compared with STZ - induced Diabetes Mellitus group.
참고문헌 (32)
- "B.V. Aspects of free radical reactions in biological systems. Aging. J. Gerontol. 1980", pp.45~53
- "Kim DH. Sensitivity of Tumor Cels to Gnaodermae Lignum", 10, pp.99~115, Orostchys Herba. K.H.Univ.O.Med.J. 1987
- "Antidiabetic efect of Panax ginseng Bery extract and the Identification of an effective component", 51, pp.1958~ (2002)
- "Screening for diabetes mellitus: a two-step approach in individuals with impaired fasting glucose improves detection of those at risk of complications", 17, pp.771~775 (2000)
- "Radicals and oxidative stress in diabetes", 17, pp.171~180 (2000)
- "Effect of sea Tangle and Metformin on lipid peroxide and antioxidant levels in diabetic rats", 32(3), pp.230~238 (1999)
- "E f e c t o f In d o n g c h o o n g l u c o s e a n d l i p i d m e t a b o l i s m and antioxidative enzyme system in streptozotocin induced diabetic rats", 17(40), pp.377~386 (2002)
- "Hypoglycemic and antioxidant effect of dietary hamcho powder in streptozotocin induced diabetic rats", 31(5), pp.840~846
- "Effects of Benincasa h i s p i d a i n t a k e o n b l o d g l u c o s e a n d l i p i d level in streptozotocin induced diabetic rats", 36(4), pp.335~353
- "Hyperglycemic and antioxidative effect of dietary Sea-Tangle extracts suplementation in streptozotocin induced diabetic rats", 37(2), pp.5~14 (2004)
- "Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation drugs", 6(4), pp.379~386 (2003)
- "and Villar A. A review of natural products and plants as potential antidiabetic drugs. J. Ethnophamacol. 1989", pp.23~276
- "Necrosis of Langerhans produced experimentaly. Lancet. I. 1943", pp.484~7
- "Studies on the diabetogenic actions of streptozotocin. Cancer Chemother Rep. 1963", pp.91~8
- "석산이 Streptozotocin으로 유발된 당뇨에 대한 면역조직화학적 연구", 19(1), pp.111~119 (2004)
- "박헌재. 消渴의 개념과 그 치료에 관한 관견. 동서의학. 1977", pp.26~31
- "김환희. 消渴에 응용되는 白虎湯이 Aloxan 당뇨에 미치는 영향. 동서의학. 1979", pp.2~31
- "이임근. 消渴의 침구치료혈에 관한 문헌적 고찰. 동서의학. 1989", pp.15~31
- "消渴의 病因病耭와 침구치료에 관한 문헌적 고찰", 4(1), pp.269~285 (1995)
- "침자극이 시험적 消渴에 미치는 영향에 대한 면역조직화e학적 연구", 2(1), pp.156~176 (1997)
- "消渴의 원인과 분류에 관한 문헌적 고찰", 20(3), pp.41~59 (1995)
- "Streptozotocin 유도 당뇨 Rat에 한약제제의 급여가 혈당 및 지질 농도에 미치는 영향", 19(1), pp.41~46 (2004)
- "Gutteridge JMC. Free radicals in b i o l o g y a n d m e d i c i n e . 2 n d e d . O x f i r d", Clarendon Press. 1989
- "Streptozotocin으로 유발한 당뇨쥐에 대한 白蠶의 영향", 6(1-2), pp.11~22 (2000)
- "Ardailou L. Reactive oxygen metabolites in experimental glomerular disease. Kidney Int. 1989", pp.1093~1106
- "Hostetter TH. The role of oxidants in progressive renal injury. Kidney Int 45", pp.111~115
- "제2형 당뇨병 환자에서의 녹차의 혈당 조절 효과", 5, pp.31~39 (1999)
- "폴리페놀 섭취가 Streptozotocin에 의한 당뇨유발 쥐의 운동중 항산화 방어기전에 미치는 영향", 6(3), pp.271~276 (2002)
- "Influence of vitamin E on the levels of fatty acids and MDA in some tissues of diabetic rats", 20(1), pp.67~71 (2002)
- "Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes", 50(9), pp.2040~2046 (2001)
- "한국 성인의 혈청 크레아티닌 정상 범위에 관한 연구", 23(5), pp.721~728 (2004)
- "당뇨1호방의 약침 및 구강투여가 Streptozotocin에 의한 흰쥐의 당뇨병성 신증에 미치는 영향", 22(5), pp.1~10 (2005)
