The significance of placental ratios in pregnancies complicated by small for gestational age, preeclampsia, and gestational diabetes mellitus
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ObjectiveThis study aimed to evaluate the placental weight, volume, and density, and investigate the significance of placentalratios in pregnancies complicated by small for gestational age (SGA), preeclampsia (PE), and gestational diabetesmellitus (GDM). MethodsTwo hundred and fifty-four pregnant women were enrolled from August 2005 through July 2013. Participants weredivided into four groups: control (n=82), SGA (n=37), PE (n=102), and GDM (n=33). The PE group was classified asPE without intrauterine growth restriction (n=65) and PE with intrauterine growth restriction (n=37). Birth weight,placental weight, placental volume, placental density, and placental ratios including birth weight/placental weightratio (BPW) and birth weight/placental volume ratio (BPV) were compared between groups. ResultsBirth weight, placental weight, and placental volume were lower in the SGA group than in the control group. However, the BPW and BPV did not differ between the two groups. Birth weight, placental weight, placental volume,BPW, and BPV were all significantly lower in the PE group than in the control group. Compared with the controlgroup, birth weight, BPW, and BPV were higher in the GDM group, whereas placental weight and volume did notdiffer in the two groups. Placental density was not significantly different among the four groups. ConclusionPlacental ratios based on placental weight, placental volume, placental density, and birth weight are helpful inunderstanding the pathophysiology of complicated pregnancies. Moreover, they can be used as predictors ofpregnancy complications.
Abstract
ObjectiveThis study aimed to evaluate the placental weight, volume, and density, and investigate the significance of placentalratios in pregnancies complicated by small for gestational age (SGA), preeclampsia (PE), and gestational diabetesmellitus (GDM). MethodsTwo hundred and fifty-four pregnant women were enrolled from August 2005 through July 2013. Participants weredivided into four groups: control (n=82), SGA (n=37), PE (n=102), and GDM (n=33). The PE group was classified asPE without intrauterine growth restriction (n=65) and PE with intrauterine growth restriction (n=37). Birth weight,placental weight, placental volume, placental density, and placental ratios including birth weight/placental weightratio (BPW) and birth weight/placental volume ratio (BPV) were compared between groups. ResultsBirth weight, placental weight, and placental volume were lower in the SGA group than in the control group. However, the BPW and BPV did not differ between the two groups. Birth weight, placental weight, placental volume,BPW, and BPV were all significantly lower in the PE group than in the control group. Compared with the controlgroup, birth weight, BPW, and BPV were higher in the GDM group, whereas placental weight and volume did notdiffer in the two groups. Placental density was not significantly different among the four groups. ConclusionPlacental ratios based on placental weight, placental volume, placental density, and birth weight are helpful inunderstanding the pathophysiology of complicated pregnancies. Moreover, they can be used as predictors ofpregnancy complications.
참고문헌 (24)
- Vedmedovska N, "Placental pathology in fetal growth restriction", Eur J Obstet Gynecol Reprod Biol, 155, pp.36~40 (2011)
- Roberts JM, "Recent Insights into the pathogenesis of pre-eclampsia", Placenta, 23, pp.359~372 (2002)
- Hunt KJ, "The increasing prevalence of diabetes in pregnancy", Obstet Gynecol Clin North Am, 34, pp.173~199 (2007)
- Godfrey KM, "The role of the placenta in fetal programming:a review", Placenta, 23(Suppl A), pp.S20~S27 (2002)
- Thame M, "Fetal growth is directly related to maternal anthropometry and placental volume", Eur J Clin Nutr, 58, pp.894~900 (2004)
- Thame M, "Second-trimester placental volume and infant size at birth", Obstet Gynecol, 98, pp.279~283 (2001)
- Pietryga M, "Ultrastructural examination of the placenta in pregnancy complicated by diabetes mellitus", Ginekol Pol, 75, pp.111~118 (2004)
- Hwang HS, "Differential expression of nestin in normal and pre-eclamptic human placentas", Acta Obstet Gynecol Scand, 86, pp.909~914 (2007)
- Hwang HS, "Increased CXCL12 expression in the placentae of women with pre-eclampsia", Eur J Obstet Gynecol Reprod Biol, 160, pp.137~141 (2012)
- Janthanaphan M, "Placental weight and its ratio to birth weight in normal pregnancy at Songkhlanagarind Hospital", J Med Assoc Thai, 89, pp.130~137 (2006)
- Strom-Roum EM, "Placental weight relative to birthweight in pregnancies with maternal diabetes mellitus", Acta Obstet Gynecol Scand, 92, pp.783~789 (2013)
- Bortolus R, "Placental ratio in pregnancies at different risk for intrauterine growth", Eur J Obstet Gynecol Reprod Biol, 80, pp.157~158 (1998)
- Mayhew TM, "The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances", Placenta, 28, pp.233~238 (2007)
- Di Cianni G, "Prevalence and risk factors for gestational diabetes assessed by universal screening", Diabetes Res Clin Pract, 62, pp.131~137 (2003)
- Azpurua H, "Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling", Am J Perinatol, 27, pp.151~155 (2010)
- Shehata F, "Placenta", birthweight ratio and perinatal outcome: a retrospective cohort analysis, 2011, pp.118, 741~747
- Higgins M, "McAuliffe FM. Stereology of the placenta in type 1 and type 2 diabetes", Placenta, 32, pp.564~569 (2011)
- Effendi M, "Association between first-trimester placental volume and birth weight", Placenta, 35, pp.99~102 (2014)
- Barker DJ, "Fetal and placental size and risk of hypertension in adult life", BMJ, 301, pp.259~262 (1990)
- Williams LA, "Prospective cohort study of factors influencing the relative weights of the placenta and the newborn infant", BMJ, 314, pp.1864~1868 (1997)
- Lao TT, "Placental ratio: its relationship with mild maternal anaemia", Placenta, 18, pp.593~596 (1997)
- Van der Velde WJ, "Smoking in pregnancy: the influence on percentile birth weight, mean birth weight, placental weight, menstrual age, perinatal mortality and maternal diastolic blood pressure", Gynecol Obstet Invest, 19, pp.57~63 (1985)
- Lao TT, "Placental ratio and anemia in thirdtrimester pregnancy", J Reprod Med, 45, pp.923~928 (2000)
- Kovo M, "Placental vascular lesion differences in pregnancyinduced hypertension and normotensive fetal growth restriction", Am J Obstet Gynecol, 202, pp.561.e1~561.e5 (2010)