The association between polycystic ovary syndrome and breast cancer: a meta-analysis
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ObjectiveThe results of epidemiological studies investigated the association between polycystic ovary syndrome (PCOS) and the breast cancer are inconsistent. This meta-analysis was conducted to estimate the association between PCOS and the breast cancer risk. We searched PubMed, Web of Science, and Scopus for observational studies until June 2015. Data were independently extracted and analyzed using 95% odds ratio, and confidence intervals (CIs) based on the random-effects models. MethodsWe identified 970 references and conducted eight studies with 45,470 participants and 243,064 person- year. ResultsThe association between PCOS and the breast cancer risk in case-control studies 0.87 (95% CI, 0.44 to 1.31) and that of cohort studies was estimated 1.18 (95% CI, 0.93 to 1.43). ConclusionThis meta-analysis demonstrated that PCOS no does increase the risk of breast cancer. Further prospective cohort studies are needed to provide convincing evidence in order to PCOS can increase or not effect on the risk of the breast cancer.
Abstract
ObjectiveThe results of epidemiological studies investigated the association between polycystic ovary syndrome (PCOS) and the breast cancer are inconsistent. This meta-analysis was conducted to estimate the association between PCOS and the breast cancer risk. We searched PubMed, Web of Science, and Scopus for observational studies until June 2015. Data were independently extracted and analyzed using 95% odds ratio, and confidence intervals (CIs) based on the random-effects models. MethodsWe identified 970 references and conducted eight studies with 45,470 participants and 243,064 person- year. ResultsThe association between PCOS and the breast cancer risk in case-control studies 0.87 (95% CI, 0.44 to 1.31) and that of cohort studies was estimated 1.18 (95% CI, 0.93 to 1.43). ConclusionThis meta-analysis demonstrated that PCOS no does increase the risk of breast cancer. Further prospective cohort studies are needed to provide convincing evidence in order to PCOS can increase or not effect on the risk of the breast cancer.
참고문헌 (25)
- Balen A, "Polycystic ovary syndrome and cancer", Hum Reprod Update, 7, pp.522~525 (2001)
- Azziz R, "The prevalence and features of the polycystic ovary syndrome in an unselected population", J Clin Endocrinol Metab, 89, pp.2745~2749 (2004)
- Barry JA, "Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis", Hum Reprod Update, 20, pp.748~758 (2014)
- Broekmans FJ, "PCOS according to the Rotterdam consensus criteria : change in prevalence among WHOII anovulation and association with metabolic factors", BJOG, 113, pp.1210~1217 (2006)
- Wild SH, "Cancer, cardiovascular disease and diabetes mortality among women with a history of endometrial cancer", Br J Cancer, 96, pp.1747~1749 (2007)
- Chittenden BG, "Polycystic ovary syndrome and the risk of gynaecological cancer : a systematic review", Reprod Biomed Online, 19, pp.398~405 (2009)
- World Health Organization, "Guidelines for management of breast cancer", World Health Organization, ~ (2006)
- Tehranian N, "Risk factors for breast cancer in Iranian women aged less than 40 years", Asian Pac J Cancer Prev, 11, pp.1723~1725 (2010)
- Fauser BC, "Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE", ASRM-Sponsored 3rd PCOS Consensus Workshop Group, 2012, pp.97, 28~38
- Ghasemi N, "Frequency of poly cystic ovary syndrome in patients with premenopausal breast cancer", Iran J Reprod Med, 8, pp.86~89 (2010)
- Anderson KE, "Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa", Cancer, 79, pp.494~499 (1997)
- Gottschau M, "Risk of cancer among women with polycystic ovary syndrome : a Danish cohort study", Gynecol Oncol, 136, pp.99~103 (2015)
- Shen CC, "A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome", Oncologist, 20, pp.45~49 (2015)
- "GRADE handbook for grading quality of evidence and strength of recommendations" (2013)[URL]
- Higgins JP, "Measuring inconsistency in meta-analyses", BMJ, 327, pp.557~560 (2003)
- Egger M, "Bias in meta-analysis detected by a simple, graphical test", BMJ, 315, pp.629~634 (1997)
- Begg CB, "Operating characteristics of a rank correlation test for publication bias", Biometrics, 50, pp.1088~1101 (1994)
- DerSimonian R, "Meta-analysis in clinical trials", Control Clin Trials, 7, pp.177~188 (1986)
- Wild S, "Long-term consequences of polycystic ovary syndrome : results of a 31year follow-up study", Hum Fertil (Camb), 3, pp.101~105 (2000)
- Coulam CB, "Chronic anovulation syndrome and associated neoplasia", Obstet Gynecol, 61, pp.403~407 (1983)
- Talamini R, "Selected medical conditions and risk of breast cancer", Br J Cancer, 75, pp.1699~1703 (1997)
- Baron JA, "Metabolic disorders and breast cancer risk(United States)", Cancer Causes Control, 12, pp.875~880 (2001)
- Poorolajal J, "Body mass index effects on risk of ovarian cancer : a meta-analysis", Asian Pac J Cancer Prev, 15, pp.7665~7671 (2014)
- Jenabi E, "The effect of body mass index on endometrial cancer : a meta-analysis", Public Health, 129, pp.872~880 (2015)
- Gadducci A, "Polycystic ovary syndrome and gynecological cancers:is there a link?", Gynecol Endocrinol, 20, pp.200~208 (2005)