본문 바로가기
KERD
논문KCI 등재

A Case of Acute Q Fever with Severe Acute Cholestatic Hepatitis

1

조회

0

다운로드

3

인용

0

참고문헌

키워드

초록

Minimal hepatic dysfunction can be common in acute Q fever, but severe acute cholestatic hepatitis is rarely reported. We report on a 55-year-old male with acute Q fever and severe acute cholestatic hepatitis. He complained of fever, jaundice, ascites, and restlessness on admission. A liver biopsy revealed the presence of compact fibrin-ring granulomas. Serologic titers for C. burnetii IgM and IgG were 2048:1 and 1024:1, respectively. C. burnetii DNA was detected by a nested polymerase chain reaction on the liver tissue.

Abstract

Minimal hepatic dysfunction can be common in acute Q fever, but severe acute cholestatic hepatitis is rarely reported. We report on a 55-year-old male with acute Q fever and severe acute cholestatic hepatitis. He complained of fever, jaundice, ascites, and restlessness on admission. A liver biopsy revealed the presence of compact fibrin-ring granulomas. Serologic titers for C. burnetii IgM and IgG were 2048:1 and 1024:1, respectively. C. burnetii DNA was detected by a nested polymerase chain reaction on the liver tissue.

참고문헌 (27)

  1. Bolaños M, "Q fever in Gran Canaria: 40 new cases", Enferm Infecc Microbiol Clin, 21, pp.20~23 (2003)
  2. Raoult D, "Q fever 1985-1998. Clinical and epidemiologic features of 1,383 infections", Medicine, 79, pp.109~123 (2007)
  3. Alarcon A, "Q fever: epidemiology, clinical features and prognosis. A study from 1983 to 1999 in the South of Spain", J Infect, 47, pp.110~116 (2003)
  4. Luksić B, "Clinical and epidemiological features of hospitalized acute Q fever cases from Split-Dalmatia County , 1985-2002", Med Sci Monit, 12, pp.CR126~131 (2002)
  5. Tissot Dupont H, "Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases", Am J Med, 93, pp.427~434 (1992)
  6. Ergas D, "Acute Q fever in Israel: clinical and laboratory study of 100 hospitalized patients", Isr Med Assoc J, 8, pp.337~341 (2006)
  7. Chang K, "Acute hepatitis with or without jaundice: a predominant presentation of acute Q fever in southern Taiwan", J Microbiol Immumol Infect, 372, pp.103~108 (2004)
  8. Rolain JM, "Acute acalculous cholecystitis associated with Q fever: report of seven cases and review of the literature", Eur J Clin Microbiol Infect Dis, 22, pp.222~227 (2003)
  9. Bernit E, "Neurological involvement in acute Q fever: a report of 29 cases and review of the literature", Arch Intern Med, 162, pp.693~700 (2002)
  10. Woldehiwet Z, "Q fever (coxiellosis): epidemiology and pathogenesis", Res Vet Sci, 77, pp.93~100 (2004)
  11. Wu CS, "Acute Q fever hepatitis in Taiwan", J Gastroenterol Hepatol, 10, pp.112~115 (1995)
  12. Cone LA, "Q fever in the Southern California desert: epidemiology, clinical presentation and treatment", Am J Trop Med Hyg, 75, pp.29~32 (2006)
  13. Moreno A, "Hepatic fibrin- ring granulomas in visceral leishmaniasis", Gastroenterology, 95, pp.1123~1126 (1988)
  14. Nenert M, "Epstein-Barr virus infection and hepatic fibrin-ring granulomas", Hum Pathol, 19, pp.608~610 (1988)
  15. de Bayser L, "Hepatic fibrin-ring granulomas in giant cell arteritis", Gastroenterology, 105, pp.272~273 (1993)
  16. Vanderstigel M, "Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas", Gastroenterology, 90, pp.188~190 (1986)
  17. Yamamoto T, "Transient hepatic fibrin-ring granulomas in a patient with acute hepatitis A", Liver, 15, pp.276~279 (1995)
  18. Glazer E, "Fibrin ring granuloma in chronic hepatitis C: virus-related vasculitis and", or immune complex disease?, 2007, pp.27, 227~230
  19. Beslagić E, "Laboratory diagnosis of Q-fever with the indirect immunofluorescence test", Med Arh, 56, pp.89~92 (2002)
  20. Dupuis G, "Immunoglobulin responses in acute Q fever", J Clin Microbiol, 22, pp.484~487 (1985)
  21. Devine P, "Combined determination of Coxiella burnetii-specific immunoglobulin M (IgM) and IgA improves specificity in the diagnosis of acute Q fever", Clin Diagn Lab Immunol, 4, pp.384~386 (1997)
  22. Chavanet P, "Comparative value of complement fixation and indirect immunofluorescence reactions for the detection of Q fever", Pathol Biol, 32, pp.53~55 (1984)
  23. Schmeer N, "Serodiagnosis of human Q-fever: demonstration of non-complement binding IgM antibodies in the enzyme-linked immunosorbent assay (ELISA)", Immun Infekt, 12, pp.245~251 (1984)
  24. Ogawa M, "Evaluation of PCR and nested PCR assays currently used for detection of Coxiella burnetii in Japan", Southeast Asian J Trop Med Public Health, 35, pp.852~855 (2004)
  25. Pérez-del-Molino A, "Eythromycin and the treatment of Coxiella burnetti pneumonia", J Antimicrob Chemother, 28, pp.455~459 (1991)
  26. Keysary A, "The in-vitro anti-rickettsial activity of macrolides", J Antimicrob Chemother, 38, pp.727~731 (1996)
  27. Gikas A, "Newer macrolides as empiric treatment for acute Q fever infection", Antimicrob Agents Chemother, 45, pp.3644~3646 (2001)

관련 논문AI추천

이 간행물의 다른 논문 (12건)