Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Although controversial, probiotics and dietary fiber are commonly used for patients with irritable bowel syndrome (IBS). We evaluated the effects of multistrain probiotics on the symptoms of IBS to determine whether the addition of dietary fi ber had an additive effect on constipation-predominant IBS. Methods: A total of 142participants who met the Rome III criteria were recruited and randomized into a control group or a test group. Participants in the control group received multistrain probiotic fermented milk with Streptococcus thermophilus, Lactobacillus acidophilus and Bifi dobacterium infantis; the participants in the test group received the same probiotic fermented milk mixed with dietary fi ber such as sea tangle extracts, radish extracts and glasswort extracts. The patients were treated for four weeks. Results: Most of the symptoms of IBS, with the exception of fl atulence, stool consistency, and frequency of defecation,signifi cantly improved in both groups. In the analysis of IBS subtypes, especially constipation-predominant IBS,the frequency and duration of defecation and straining at stool were improved more in the test group than in the control group. Conclusions: Dietary fiber had additive benefits for the symptoms of constipation, especially in constipationpredominant IBS.
Abstract
Background/Aims: Although controversial, probiotics and dietary fiber are commonly used for patients with irritable bowel syndrome (IBS). We evaluated the effects of multistrain probiotics on the symptoms of IBS to determine whether the addition of dietary fi ber had an additive effect on constipation-predominant IBS. Methods: A total of 142participants who met the Rome III criteria were recruited and randomized into a control group or a test group. Participants in the control group received multistrain probiotic fermented milk with Streptococcus thermophilus, Lactobacillus acidophilus and Bifi dobacterium infantis; the participants in the test group received the same probiotic fermented milk mixed with dietary fi ber such as sea tangle extracts, radish extracts and glasswort extracts. The patients were treated for four weeks. Results: Most of the symptoms of IBS, with the exception of fl atulence, stool consistency, and frequency of defecation,signifi cantly improved in both groups. In the analysis of IBS subtypes, especially constipation-predominant IBS,the frequency and duration of defecation and straining at stool were improved more in the test group than in the control group. Conclusions: Dietary fiber had additive benefits for the symptoms of constipation, especially in constipationpredominant IBS.
참고문헌 (29)
- Kajander K, "A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention", Aliment Pharmaco Ther, 22, pp.387~394 (2005)
- Drossman DA, "AGA technical review on irritable bowel syndrome", Gastroenterology, 123, pp.2108~2131 (2002)
- Parkes GC, "Gastrointestinal microbiota in irritable bowel syndrome: their role in its pathogenesis and treatment", Am J Gastroenterol, 103, pp.1557~1567 (2008)
- Chadwick VS, "Activation of the mucosal immune system in irritable bowel syndrome", Gastroenterology, 122, pp.1778~1783 (2002)
- Nobaek S, "Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome", Am J Gastroenterol, 95, pp.1231~1338 (2000)
- Kim HJ, "A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating", Neurogastroenterol Motil, 17, pp.687~696 (2005)
- Kyoung Sup Hong, "Effect of Probiotics on Symptoms in Korean Adults with Irritable Bowel Syndrome", Gut and Liver, 3(2), pp.101~107 (2009), 거트앤리버 발행위원회
- O’Mahony L, "Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles", Gastroenterology, 128, pp.541~551 (2005)
- Sinn DH, "Therapeutic effect of Lactobacillus acidophilus-SDC 2012, 2013 in patients with irritable bowel syndrome", Dig Dis Sci, 53, pp.2714~2718 (2008)
- Whorwell PJ, "Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome", Am J Gastroenterol, 101, pp.1581~1590 (2006)
- Sen S, "Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable bowel syndrome", Dig Dis Sci, 47, pp.2615~2620 (2002)
- Tsuchiya J, "Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome", Chin J Dig Dis, 5, pp.169~174 (2004)
- Agrawal A, "Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173-010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation", Aliment Pharmacol Ther, 29, pp.104~114 (2009)
- Williams E, "Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study", Aliment Pharmacol Ther, 29, pp.97~103 (2009)
- O’Sullivan MA, "Bacterial supplementation in the irritable bowel syndrome. A randomised double-blind placebocontrolled crossover study", Dig Liver Dis, 32, pp.294~301 (2000)
- Camilleri M, "Management of the irritable bowel syndrome", Gastroenterology, 120, pp.652~668 (2001)
- Camilleri M, "Clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome", Aliment Pharmacol Ther, 16, pp.1407~1430 (2002)
- Zuckerman MJ, "The role of fiber in the treatment of irritable bowel syndrome: therapeutic recommendations", J Clin Gastroenterol, 40, pp.104~108 (2006)
- Niv E, "The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome: a double blind, placebo-controlled, randomized study", Clin Nutr, 24, pp.925~931 (2005)
- Drouault-Holowacz S, "A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome", Gastroenterol Clin Biol, 32, pp.147~152 (2008)
- Zeng J, "Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome", Aliment Pharmacol Ther, 28, pp.994~1002 (2008)
- Rousseaux C, "Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors", Nat Med, 13, pp.35~37 (2007)
- Guyonnet D, "Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syn drome in adults in primary care: a multicentre, randomized, double- blind, controlled trial", Aliment Pharmacol Ther, 26, pp.475~486 (2007)
- Jijon H, "DNA from probiotic bacteria modulates murine and human epithelial and immune function", Gastroenterology, 126, pp.1358~1573 (2004)
- King TS, "Abnormal colonic fermentation in irritable bowel syndrome", Lancet, 352, pp.1187~1189 (1998)
- O’Mahony L, "Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice", Aliment Pharmacol Ther, 15, pp.1219~1225 (2001)
- Zareie M, "Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress", Gut, 55, pp.1553~1560 (2006)
- Bijkerk CJ, "Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome", Aliment Pharmacol Ther, 19, pp.245~251 (2004)
- Pitz M, "Defining the predictors of the placebo response in irritable bowel syndrome", Clin Gastroenterol Hepatol, 3, pp.237~247 (2005)