Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background/Aims: To investigate serological patterns of hepatitis B based on electrochemiluminescent immunoassays and the distribution characteristics of these patterns in hospitalized children and adolescents in Zhejiang, China between 2006 and 2010. Methods: Five serological markers,including hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B e antigen (anti-HBe), and antibody to hepatitis B c antigen (anti-HBc), were chosen as a routine panel to monitor hepatitis B virus (HBV) infection and vaccination effi cacy. A total of 33,187 children (21,187boys and 12,000 girls) were selected using the following exclusion criteria: a previous diagnosis of hepatitis, age >16years or an address outside of Zhejiang. Results: The average HBV vaccination coverage rates among 20,766 boys and 11,782 girls were 98.62% and 98.68%, respectively. Seventeen serological patterns of hepatitis B were found,and the dominant pattern was ‘anti-HBs (+) alone’ (62.03%)followed by ‘negative pattern’ (23.46%). The rates of the other 15 patterns ranged from 8.14% to 0.003%. Of 236HBsAg-positive patients, the overall rate of seropositivity was 0.71%. The anti-HBs levels were grouped into 3 ranges (10-100 mIU/mL, 100-1,000 mIU/mL, and >1,000 mIU/mL) for all anti-HBs-positive children (36.08%, 43.43%, and 20.49%,respectively). Conclusions: A low HBsAg carrier rate and a relatively high anti-HBs positive rate are present in hospitalized children and adolescents in Zhejiang. The distribution of serological patterns is associated with age but is mostly independent of gender.
Abstract
Background/Aims: To investigate serological patterns of hepatitis B based on electrochemiluminescent immunoassays and the distribution characteristics of these patterns in hospitalized children and adolescents in Zhejiang, China between 2006 and 2010. Methods: Five serological markers,including hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B e antigen (anti-HBe), and antibody to hepatitis B c antigen (anti-HBc), were chosen as a routine panel to monitor hepatitis B virus (HBV) infection and vaccination effi cacy. A total of 33,187 children (21,187boys and 12,000 girls) were selected using the following exclusion criteria: a previous diagnosis of hepatitis, age >16years or an address outside of Zhejiang. Results: The average HBV vaccination coverage rates among 20,766 boys and 11,782 girls were 98.62% and 98.68%, respectively. Seventeen serological patterns of hepatitis B were found,and the dominant pattern was ‘anti-HBs (+) alone’ (62.03%)followed by ‘negative pattern’ (23.46%). The rates of the other 15 patterns ranged from 8.14% to 0.003%. Of 236HBsAg-positive patients, the overall rate of seropositivity was 0.71%. The anti-HBs levels were grouped into 3 ranges (10-100 mIU/mL, 100-1,000 mIU/mL, and >1,000 mIU/mL) for all anti-HBs-positive children (36.08%, 43.43%, and 20.49%,respectively). Conclusions: A low HBsAg carrier rate and a relatively high anti-HBs positive rate are present in hospitalized children and adolescents in Zhejiang. The distribution of serological patterns is associated with age but is mostly independent of gender.
참고문헌 (26)
- Custer B, "Global epidemiology of hepatitis B virus", J Clin Gastroenterol, 38(10 Suppl 3), pp.S158~S168 (2004)
- McCartney RA, "Comparison of enhanced chemiluminescence and microparticle enzyme immunoassay for the measurement of hepatitis B surface antibody", Vaccine, 11, pp.941~945 (1993)
- Diepersloot RJ, "Comparison of a chemiluminescent immunoassay with two microparticle enzyme immunoassays for detection of hepatitis B virus surface antigen", Clin Diagn Lab Immunol, 7, pp.865~866 (2000)
- 허희진, "효소면역측정법과 화학발광면역측정법을 이용한 B형간염표면항원 검사의 비교", Annals of Laboratory Medicine, 27(5), pp.355~359 (2007), 대한진단검사의학회
- Lu FM, "Management of hepatitis B in China", Chin Med J (Engl), 122, pp.3~4 (2009)
- Mushahwar IK, "Interpretation of various serological profiles of hepatitis B virus infection", Am J Clin Pathol, 76, pp.773~777 (1981)
- Irshad M, "Interpretation of serological markers of hepatitis viruses", Trop Gastroenterol, 16, pp.4~10 (1995)
- Mujeeb SA, "Serological markers of hepatitis B infection: a study to reduce cost and improve interpretation", Infect Dis J Pakistan, 16, pp.17~19 (2007)
- Alhababi F, "The significance of ‘anti-HBc only’ in the clinical virology laboratory", J Clin Virol, 27, pp.162~169 (2003)
- Knöll A, "Serological pattern “anti-HBc alone”: characterization of 552 individuals and clinical significance", World J Gastroenterol, 12, pp.1255~1260 (2006)
- Wang Z, "Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies", J Med Virol, 71, pp.360~366 (2003)
- Qiu L, "Hepatitis B and breastfeeding in Hangzhou, Zhejiang Province, People’s Republic of China", Breastfeed Med, 5, pp.109~112 (2010)
- Patterson W, "Random and continuous- access immunoassays with chemiluminescent detection by Access automated analyzer", Clin Chem, 40(11 Pt 1), pp.2042~2045 (1994)
- Hadler SC, "Hepatitis B immunization: vaccine types, efficacy, and indications for immunization", C rr Clin Top Infect Dis, 12, pp.282~308 (1992)
- Köksal N, "Transient hepatitis B surface antigenemia after neonatal hepatitis B immunization", Acta Paediatr, 85, pp.1501~1502 (1996)
- Liang X, "Epidemiological serosurvey of hepatitis B in China: declining HBV prevalence due to hepatitis B vaccination", Vaccine, 27, pp.6550~6557 (2009)
- El-Magrahe H, "Maternal and neonatal seroprevalence of Hepatitis B surface antigen (HBsAg) in Tripoli, Libya", J Infect Dev Ctries, 4, pp.168~170 (2010)
- Utsumi T, "Serologic and molecular characteristics of hepatitis B virus among school children in East Java, Indonesia", Am J Trop Med Hyg, 83, pp.189~193 (2010)
- Alikor EA, "Seroprevalence of hepatitis B surface antigenaemia in children in a tertiary health institution in the Niger Delta of Nigeria", Niger J Med, 16, pp.326~329 (2007)
- Liang X, "Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China", J Infect Dis, 200, pp.39~47 (2009)
- Gold Y, "Decreased immune response to hepatitis B eight years after routine vaccination in Israel", Acta Paediatr, 92, pp.1158~1162 (2003)
- Poland GA, "Clinical practice: prevention of hepatitis B with the hepatitis B vaccine", N Engl J Med, 351, pp.2832~2838 (2004)
- Zhang L, "Analysis on hepatitis B vaccine coverage among the population of 1-59 years old in Shandong province", Zhongguo Yi Miao He Mian Yi, 15, pp.159~162 (2009)
- Lu JJ, "Hepatitis B immunity in adolescents and necessity for boost vaccination: 23 years after nationwide hepatitis B virus vaccination program in Taiwan", Vaccine, 27, pp.6613~6618 (2009)
- Zhou YH, "Vaccination against hepatitis B: the Chinese experience", Chin Med J (Engl), 122, pp.98~102 (2009)
- Dong Y, "A serological and molecular survey of hepatitis B in children 15 years after inception of the national hepatitis B vaccination program in eastern China", J Med Virol, 81, pp.1517~1524 (2009)