葎草 추출물이 Rat의 paw edema에 미치는 영향
Anti-inflammaory effects of the MeOH extract of Humulus japonicus in vitro
1
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Objectives : The present study was examined to evaluate the anti-inflammatory effects of the Humulus japonicus MeOH extracts (HJE) in the carrageenan-induced paw edema model in rats. Methods : The effects of HJE on anti-inflammation were measured in the carrageenan-induced paw edema model in rats and infiltrated Inflammatory Cells. Results : 1. HJE (1.0 g/kg) and dexamethasone effectively inhibited paw edema measured 1~4 h after carrageenan injection. HJE (0.3 g/kg) effectively inhibited paw edema measured 1, 3, 4 hr. 2. In histopathological study in rats, 1.0 g/kg HJE and dexamethasone effectively inhibited the increases of hind paw skin thicknesses and inflammatory cell infiltrations induced by carrageenan treatment. But quite similar histopathological changes were detected in 0.3 g/kg HJE treated group as compared with carrageenan control.
Abstract
Objectives : The present study was examined to evaluate the anti-inflammatory effects of the Humulus japonicus MeOH extracts (HJE) in the carrageenan-induced paw edema model in rats. Methods : The effects of HJE on anti-inflammation were measured in the carrageenan-induced paw edema model in rats and infiltrated Inflammatory Cells. Results : 1. HJE (1.0 g/kg) and dexamethasone effectively inhibited paw edema measured 1~4 h after carrageenan injection. HJE (0.3 g/kg) effectively inhibited paw edema measured 1, 3, 4 hr. 2. In histopathological study in rats, 1.0 g/kg HJE and dexamethasone effectively inhibited the increases of hind paw skin thicknesses and inflammatory cell infiltrations induced by carrageenan treatment. But quite similar histopathological changes were detected in 0.3 g/kg HJE treated group as compared with carrageenan control.
참고문헌 (17)
- 신민교, "임상본초학", pp.449~450 (1997), 영림사
- 김창민, "중약대사전", pp.4377~4380 (1998), 정담
- 이정헌, "Methotrexate의 심근독성에 대한 율草의 효과", 동의생리병리학회지, 15(4), pp.585~989 (2001), 대한동의병리학회
- 박승우, "환삼덩굴로부터 분리한 Luteolin-7-O-β-D-Glucoside의 활성산소 소거능", 한국식품영양과학회지, 29(1), pp.106~110 (2000)
- 황순이, "葎草가 항염 효과에 미치는 영향", 한방안이비인후피부과학회지, 22(2), pp.92~103 (2009), 대한한방안이비인후피부과학회
- 임덕빈, "율초가 진통 소염 이뇨작용에 미치는 영향", 본초분과학회지, 8(1), pp.69~75 (1993)
- KIM, HYEONG-DONG, "Effect of Exopolymers from Aureobasidium pullulans on Formalin-Induced Chronic Paw Inflammation in Mice", Journal of Microbiology and Biotechnology, 16(12), pp.1954~1960 (2006), 한국미생물·생명공학회
- 박광균, "구강생화학", pp.318~325 (1999), 군자출판사
- 약품생화학분과위원회편, "분자약품생화학", pp.59~71 (2003), 동명사
- 정순영, "三黃洗劑가 Raw 264.7 cell 에서의 항염 효과에 미치는 영향", 한방안이비인후피부과학회지, 22(1), pp.108~119 (2009), 대한한방안이비인후피부과학회
- 陶弘景, "名醫別錄", pp.165~ (1986), 人民衛生出版社
- Gupta M, "Antiinflammatory evaluation of leaves of Plumeria acuminata", BMC Complement Altern Med, 6, pp.36~ (2006)
- Rao CV, "Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals", Acta Pharm, 57, pp.491~498 (2007)
- Holt S, "Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors", Br J Pharmacol, 146, pp.467~476 (2005)
- Liu J, "Anti-inflammatory effect and mechanism of osthole in rats", Zhong Yao Cai, 28, pp.1002~1006 (2005)
- Beloeil H, "Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines", Anesthesiology, 105, pp.128~138 (2006)
- Kim YW, "Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production", Br J Pharmacol, 154(1), pp.165~173 (2008)