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Host-Microbiome Interactions in Alcoholic Liver Disease

Bernd Schnabl|Peng Chen
거트앤리버 소화기연관학회협의회|2014.05|Gut and Liver|제8권 제3호|pp. 237-241

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참고문헌

키워드

MetabolismPermeabilityMicrobiotaAlcoholic liver injury

초록

Alcoholic liver disease is a leading cause of morbidity andliver-related death worldwide. Intestinal bacterial overgrowthand dysbiosis induced by ethanol ingestion play an importantrole in the pathogenesis of alcoholic liver disease. Afterexposure to alcohol in the lumen, enteric bacteria alter theirmetabolism and thereby disturb intestinal homeostasis. Disruptionof the mucosal barrier results in the translocation ofmicrobial products that contribute to liver disease by inducinghepatic inflammation. In this review, we will discuss theeffects of alcohol on the intestinal microbiome, and in particular,its effects on bacterial metabolism, bacterial translocationand ecological balance. A better understanding of theinteractions among alcohol, the host and the microbiome willreveal new targets for therapy and lead to new treatments.

Abstract

Alcoholic liver disease is a leading cause of morbidity andliver-related death worldwide. Intestinal bacterial overgrowthand dysbiosis induced by ethanol ingestion play an importantrole in the pathogenesis of alcoholic liver disease. Afterexposure to alcohol in the lumen, enteric bacteria alter theirmetabolism and thereby disturb intestinal homeostasis. Disruptionof the mucosal barrier results in the translocation ofmicrobial products that contribute to liver disease by inducinghepatic inflammation. In this review, we will discuss theeffects of alcohol on the intestinal microbiome, and in particular,its effects on bacterial metabolism, bacterial translocationand ecological balance. A better understanding of theinteractions among alcohol, the host and the microbiome willreveal new targets for therapy and lead to new treatments.

참고문헌 (44)

  1. Mandayam S, "Epidemiology of alcoholic liver disease", Semin Liver Dis, 24, pp.217~232 (2004)
  2. Li TK, "Quantifying the risk for alcohol-use and alcohol-attributable health disorders: present findings and future research needs", J Gastroenterol Hepatol, 23(Suppl 1), pp.S2~S8 (2008)
  3. Szabo G, "Alcoholic liver disease and the gut-liver axis", World J Gastroenterol, 16, pp.1321~1329 (2010)
  4. Mathurin P, "Exacerbation of alcoholic liver injury by enteral endotoxin in rats", Hepatology, 32, pp.1008~1017 (2000)
  5. Bode C, "Effect of alcohol consumption on the gut", Best Pract Res Clin Gastroenterol, 17, pp.575~592 (2003)
  6. Bode JC, "Jejunal microflora in patients with chronic alcohol abuse", Hepatogastroenterology, 31, pp.30~34 (1984)
  7. Casafont Morencos F, "Small bowel bacterial overgrowth in patients with alcoholic cirrhosis.", Dig Dis Sci, 41, pp.552~556 (1996)
  8. Pande C, "Small-intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease", Aliment Pharmacol Ther, 29, pp.1273~1281 (2009)
  9. Yan AW, "Enteric dysbiosis associated with a mouse model of alcoholic liver disease", Hepatology, 53, pp.96~105 (2011)
  10. Hartmann P, "Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice", Hepatology, 58, pp.108~119 (2013)
  11. Hartmann P, "The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease", Front Physiol, 3, pp.402~ (2012)
  12. Mutlu E, "Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats", Alcohol Clin Exp Res, 33, pp.1836~1846 (2009)
  13. Mutlu EA, "Colonic microbiome is altered in alcoholism", Am J Physiol Gastrointest Liver Physiol, 302, pp.G966~G978 (2012)
  14. Chen Y, "Characterization of fecal microbial communities in patients with liver cirrhosis", Hepatology, 54, pp.562~572 (2011)
  15. Yan AW, "Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease", World J Hepatol, 4, pp.110~118 (2012)
  16. Bjarnason I, "The leaky gut of alcoholism: possible route of entry for toxic compounds", Lancet, 1, pp.179~182 (1984)
  17. Keshavarzian A, "differing effects of acute and chronic alcohol on gastric and intestinal permeability", Am J Gastroenterol, 89, pp.2205~2211 (1994)
  18. Keshavarzian A, "Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage", Am J Gastroenterol, 94, pp.200~207 (1999)
  19. Parlesak A, "Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease", J Hepatol, 32, pp.742~747 (2000)
  20. Wang Y, "Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury", Am J Physiol Gastrointest Liver Physiol, 303, pp.G32~G41 (2012)
  21. Zhong W, "The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction", Am J Physiol Gastrointest Liver Physiol, 298, pp.G625~G633 (2010)
  22. Seth A, "L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer", Am J Physiol Gastrointest Liver Physiol, 287, pp.G510~G517 (2004)
  23. Rao RK, "Acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer", Alcohol Clin Exp Res, 22, pp.1724~1730 (1998)
  24. Rao RK, "Acetaldehyde-induced barrier disruption and paracellular permeability in Caco-2 cell monolayer", Methods Mol Biol, 447, pp.171~183 (2008)
  25. Henao-Mejia J, "Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity", Nature, 482, pp.179~185 (2012)
  26. Ferrier L, "Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents", Am J Pathol, 168, pp.1148~1154 (2006)
  27. Fukui H, "Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay", J Hepatol, 12, pp.162~169 (1991)
  28. Rivera CA, "Role of endotoxin in the hypermetabolic state after acute ethanol exposure", Am J Physiol, 275, pp.G1252~G1258 (1998)
  29. Roh YS, "Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis", J Gastroenterol Hepatol, 28(Suppl 1), pp.38~42 (2013)
  30. Uesugi T, "Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice", Hepatology, 34, pp.101~108 (2001)
  31. Yin M, "Reduced early alcohol-induced liver injury in CD14-deficient mice", J Immunol, 166, pp.4737~4742 (2001)
  32. Uesugi T, "Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice", J Immunol, 168, pp.2963~2969 (2002)
  33. Frances R, "A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites", Hepatology, 39, pp.484~491 (2004)
  34. Romics L Jr, "Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice", Hepatology, 40, pp.555~564 (2004)
  35. Salaspuro V, "Ethanol oxidation and acetaldehyde production in vitro by human intestinal strains of Escherichia coli under aerobic, microaerobic, and anaerobic conditions", Scand J Gastroenterol, 34, pp.967~973 (1999)
  36. Tillonen J, "Role of catalase in in vitro acetaldehyde formation by human colonic contents", Alcohol Clin Exp Res, 22, pp.1113~1119 (1998)
  37. Seitz HK, "Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat", Gastroenterology, 98, pp.406~413 (1990)
  38. Nosova T, "Characteristics of aldehyde dehydrogenases of certain aerobic bacteria representing human colonic flora", Alcohol Alcohol, 33, pp.273~280 (1998)
  39. Xie G, "Chronic ethanol consumption alters mammalian gastrointestinal content metabolites", J Proteome Res, 12, pp.3297~3306 (2013)
  40. Thomson AD, "Jeyasingham MD, Pratt OE, Shaw GK. Nutrition and alcoholic encephalopathies", Acta Med Scand Suppl, 717, pp.55~65 (1987)
  41. Cook CC, "B Vitamin deficiency and neuropsychiatric syndromes in alcohol misuse", Alcohol Alcohol, 33, pp.317~336 (1998)
  42. Said HM, "Intestinal absorption of water-soluble vitamins in health and disease", Biochem J, 437, pp.357~372 (2011)
  43. Burkholder PR, "Synthesis of vitamins by intestinal bacteria", Proc Natl Acad Sci U S A, 28, pp.285~289 (1942)
  44. Catanzaro JA, "Microbial ecology and dysbiosis in human medicine", Alt Med Rev, 2, pp.202~209 (1997)

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